A5059187221- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Axon Guidance and Neuronal Signaling
- Neurosurgical Procedures and Complications
- Anesthesia and Neurotoxicity Research
- Global Health Care Issues
- Mitochondrial Function and Pathology
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Global Maternal and Child Health
- Substance Abuse Treatment and Outcomes
- Spine and Intervertebral Disc Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Child Nutrition and Water Access
- Alcohol Consumption and Health Effects
- Inflammasome and immune disorders
- Birth, Development, and Health
- Global Public Health Policies and Epidemiology
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Neuroscience of respiration and sleep
Loma Linda University
2015-2025
Kaiser Permanente
2023
VA Loma Linda Healthcare System
2021
Loma Linda University Medical Center
2015-2020
Kaiser Permanente Riverside Medical Center
2020
Institute for Health Metrics and Evaluation
2018-2019
Baxter (United States)
2019
University of Washington
2018-2019
Auckland University of Technology
2018-2019
Zhejiang University
2018
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 provides an up-to-date analysis the burden diarrhoea in 195 countries. This study assesses cases, deaths, aetiologies 1990-2016 how has changed people all ages.We modelled mortality with a Bayesian hierarchical modelling platform that evaluates wide range covariates model types on basis vital registration verbal autopsy data. We incidence compartmental meta-regression tool enforces association between prevalence,...
Kindergarten teachers play an important role in providing kindergarten children with education on nutrition. However, few studies have been published nutrition-related knowledge, attitudes, and practices (KAP) of Chinese teachers. This study aimed to assess the Chongqing, China. Thus, a cross-sectional survey was conducted using structured KAP model questionnaire administered 222 teachers, who were senior from 80 kindergartens 19 districts 20 counties Chongqing. Multiple regression analysis...
In this study, we investigated the role of vitamin D3 (VitD3) on endogenous osteopontin (OPN), a neuroprotective glycoprotein, after subarachnoid hemorrhage (SAH). The endovascular perforation SAH model in Sprague-Dawley rats was used to study effect intranasal VitD3 (30 ng/kg) before (Pre-SAH + VitD3) and (Post-SAH hemorrhage. Vitamin (30, 60, 120 ng/kg/day) increased more than one fold OPN expression astrocytes endothelial cells rat brain. significantly decreased brain edema Evans blue...
The aim of this study is to identify the early predictors for delayed cerebral ischemia (DCI) and develop a risk stratification score by focusing on change after aneurysmal subarachnoid hemorrhage (aSAH).The retrospectively reviewed aSAH patients between 2014 2015. Risk factors within 72 hours were included into univariable multivariable logistic regression analysis screen independent DCI design score.We analyzed 702 patients; four retained from final analysis: World Federation Neurosurgical...
Neuroinflammation plays an important role in the pathophysiology of surgical brain injury (SBI). Phosphoinositide 3-kinase gamma (PI3Kγ), predominately expressed immune and endothelial cells, activates multiple inflammatory responses. In present study, we investigated PI3Kγ PI3Kγ-activated phosphodiesterase 3B (PDE3B) neuroinflammation a rat model SBI. One hundred fifty-two male Sprague Dawley rats (weight 280–350 g) were subjected to partial right frontal lobe corticotomy A pharmacological...
Netrin-1 (NTN-1) has been established to be a novel intrinsic regulator of blood-brain barrier (BBB) maintenance. This study was carried out investigate the potential roles exogenous NTN-1 in preserving BBB integrity after experimental subarachnoid hemorrhage (SAH) as well underlying mechanisms its protective effects.A total 309 male Sprague-Dawley rats were subjected an endovascular perforation model SAH. Recombinant administered intravenously 1 hour SAH induction. small interfering RNA or...
Abstract Aim To determine the effect of osteopontin (OPN) on autophagy and autophagy‐apoptosis interactions after SAH. Methods The endovascular perforation model SAH or sham surgery was performed in a total 86 Sprague‐Dawley male rats. temporal expressions endogenous OPN autophagy‐related proteins (Beclin 1, ATG5, LC3 II to I ratio) were measured rats at different time points (3, 6, 12, 24, 72 hours). Rats randomly divided into three groups: Sham, + Vehicle (PBS, phosphate‐buffered saline),...