Gurudatta Naik
A5004703610- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Climate Change and Health Impacts
- Ferroptosis and cancer prognosis
- Global Health Care Issues
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Global Public Health Policies and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Health disparities and outcomes
- Lymphoma Diagnosis and Treatment
- Genital Health and Disease
- Cancer, Lipids, and Metabolism
- Global Cancer Incidence and Screening
- Cancer, Hypoxia, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Urinary and Genital Oncology Studies
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
University of Alabama at Birmingham
2014-2024
Institute for Health Metrics and Evaluation
2018-2024
University of Washington
2018-2024
O'Neal Comprehensive Cancer Center
2020-2022
Bhaktivedanta Hospital & Research Institute
2022
Weatherford College
2022
Auckland University of Technology
2018-2019
University of Groningen
2018
University of South Alabama Medical Center
2017
Sylvester Comprehensive Cancer Center
2014-2016
BackgroundThe number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding disease burden. We aimed present first detailed analysis global prevalence, mortality, overall burden as captured by Global Burden Diseases, Injuries, Risk Factors (GBD) Study 2016, highlight most important messages for clinicians neurologists.MethodsGBD 2016...
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 provides an up-to-date analysis the burden diarrhoea in 195 countries. This study assesses cases, deaths, aetiologies 1990-2016 how has changed people all ages.We modelled mortality with a Bayesian hierarchical modelling platform that evaluates wide range covariates model types on basis vital registration verbal autopsy data. We incidence compartmental meta-regression tool enforces association between prevalence,...
Brain and CNS cancers (collectively referred to as cancers) are a source of mortality morbidity for which diagnosis treatment require extensive resource allocation sophisticated diagnostic therapeutic technology. Previous epidemiological studies limited specific geographical regions or time periods, making them difficult compare on global scale. In this analysis, we aimed provide comparable comprehensive estimation the burden brain cancer between 1990 2016.We report means 95% uncertainty...
We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by mouse double minute 2 (MDM2) and MDMX to induce cell-cycle arrest or apoptosis in TP53-wild-type (WT) tumors.Two schedules were evaluated safety, pharmacokinetics, pharmacodynamics, antitumor effects patients with solid tumors lymphomas. In arm A, received ALRN-6924 intravenous infusion once-weekly 3 weeks every 28 days; B was twice-weekly 21...
<h3>Background</h3> The tumor immune microenvironment has become the focus of research in clear cell renal carcinoma (ccRCC) due to its important role surveillance post nephrectomy. This study investigates correlation infiltrating characteristics with rates recurrence following surgery localized ccRCC. <h3>Methods</h3> We morphologically identified and scored lymphocytes (TILs) hematoxylin eosin (H&E) stained slides patients ccRCC (stage ≥T1b excluding stage IV). University Alabama at...
BACKGROUND Biomarker‐guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue is not available eligible. Technological advancements sequencing have made cell‐free circulating DNA (cfDNA) next‐generation (NGS) readily the clinic. The objective of current study was to determine whether genomic profile mUC detected by NGS cfDNA similar historical studies. A secondary frequency alterations (GAs) differed between...
Abstract Human tubulin beta class IVa (TUBB4A) is a member of the β-tubulin family. In most normal tissues, expression TUBB4A little to none, but it highly expressed in human prostate cancer. Here we show that high levels are associated with aggressive cancers and poor patient survival, especially for African-American men. Additionally, cancer cells, knockout (KO) reduces cell growth migration induces DNA damage through increased γH2AX 53BP1. Furthermore, during constricted migration,...
Metastatic urothelial carcinoma is generally incurable with current systemic therapies. Chromatin modifiers are frequently mutated in bladder cancer, ARID1A-inactivating mutations present about 20% of tumors. EZH2, a histone methyltransferase, acts as an oncogene that functionally opposes ARID1A. In addition, PI3K signaling activated more than cancers. Using combination vitro and vivo data, including patient-derived xenografts, we show ARID1A-mutant tumors were sensitive to EZH2 inhibition...
Abstract Background Because cell‐free DNA (cfDNA) analysis facilitates the noninvasive genomic profiling of metastatic castration‐resistant prostate cancer (mCRPC), authors evaluated association between cfDNA alterations and outcomes evolution with therapy. Methods Patients mCRPC underwent using Guardant360, which examines major cancer‐associated genes. Clinical factors, therapy information, failure‐free survival, overall survival (OS) were obtained for select patients. The was investigated....
The Cancer Genome Atlas (TCGA) and other large-scale genomic data pipelines have been integral to the current understanding of molecular events underlying renal cell carcinoma (RCC). These networks focused mostly on primary RCC, which often demonstrates indolent behavior. However, metastatic disease is major cause mortality associated with RCC sets examining tumors are sparse. Therefore, a more comprehensive analysis gene expression DNA methylome profiling in addition normal kidney was...
Summary A semi‐automated imaging system is described to quantitate estrogen and progesterone receptor immunoreactivity in human breast cancer. The works for any conventional method of image acquisition using microscopic slides that have been processed immunohistochemical analysis the receptor. Estrogen staining produce colorimetric differences nuclear conventionally interpreted manually by pathologists expressed as percentage positive tumoral nuclei. status cancer represent important...
Despite the widespread use of kinase-targeted agents in clear cell renal carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling) these tumors is lacking. Thus, kinomic profiling CC-RCC may assist devising a classification system associated with clinical outcomes, and help identify potential therapeutic targets. Fresh frozen tumor lysates from 41 clinically annotated patients who had localized disease at diagnosis were kinomically profiled using PamStation®12...
Although c-MYC and mTOR are frequently activated proteins in prostate cancer, any interaction between the two is largely untested. Here, we characterize functional cross-talk FOXP3-c-MYC TSC1-mTOR signaling during tumor progression. Deletion of Tsc1 mouse embryonic fibroblasts (MEF) decreased phosphorylation at threonine 58 (pT58) increased serine 62 (pS62), an observation validated cancer cells. Conversely, inhibition pT58 but pS62. Loss both FOXP3 TSC1 cells synergistically enhanced...
Nano-liposomal irinotecan (nal-IRI) plus 5-fluorouracil/leucovorin (5-FU/LV) is the regimen of choice in 2nd line setting for advanced pancreatic adenocarcinoma (PAC). However, real-world data limited. Our objectives were to elicit real-word effectiveness and safety this combination as an therapy cancer patients analyze impact prior lines on survival outcomes with regimen.We conducted a retrospective cohort study 58 locally unresectable or metastatic PAC, who treated at least one dose...
Introduction and objectives: Metastatic penile squamous cell carcinoma (PSCC) is associated with dismal outcomes median overall survival (OS) of 6-12 months in the first-line <6 salvage setting. Given rarity this disease, randomized trials are difficult. Prognostic risk models may assist rational drug development by comparing observed nonrandomized phase II studies retrospective data vs. predicted based on baseline prognostic factors context historically used agents. In study, we constructed...
Kinases are therapeutically actionable targets. Kinase inhibitors targeting vascular endothelial growth factor receptors (VEGFR) and mammalian target of rapamycin (mTOR) improve outcomes in metastatic clear cell renal carcinoma (ccRCC), but not curative. Metastatic tumor tissue has been comprehensively studied for kinase gene expression. Paired intra-patient expression analysis primary (T), matched normal kidney (N) (M) may assist identifying drivers metastasis prioritizing therapeutic We...
Penile squamous cell carcinoma (PSCC) is an orphan malignancy with poorly understood biology and suboptimal systemic therapy. Given that kinases may be drivers readily actionable, we performed comprehensive multiplatform analysis of in PSCC tumor normal tissue. Fresh frozen tumors were collected from 11 patients PSCC. After macrodissection to demarcate tissue, the samples underwent kinases. Next Generation Sequencing (NGS) 517 kinase genes was using Agilent Kinome capture run on Illumina...