A5100745653- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Phytochemistry and Biological Activities
- Natural Compound Pharmacology Studies
- Acute Lymphoblastic Leukemia research
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Hematological disorders and diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Eosinophilic Disorders and Syndromes
- Bioactive natural compounds
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Chromium effects and bioremediation
- Synthesis of Indole Derivatives
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- Bone and Joint Diseases
- Environmental remediation with nanomaterials
- Cancer-related Molecular Pathways
- Sulfur Compounds in Biology
- Mesenchymal stem cell research
- Kruppel-like factors research
Second Hospital of Shanxi Medical University
2016-2025
Shanxi Medical University
2016-2025
Chinese Academy of Sciences
2013-2024
Institute of Geology and Geophysics
2011-2024
University of Chinese Academy of Sciences
2024
South China Botanical Garden
2012-2022
Beijing Botanical Garden
2012-2022
University of Alabama at Birmingham
2021-2022
Shanxi University
2016-2019
Third Hospital of Hebei Medical University
2019
Chloroplasts undergo drastic morphological and physiological changes during senescence with a visible symptom of chlorophyll (Chl) degradation. A stay green mutant was identified then isolated from the japonica rice (Oryza sativa) cv. Huazhiwu by gamma-ray irradiation. The characterized Chl retention, stable Chl-protein complexes, thylakoid membrane structures, but lost its photosynthetic competence senescence. gene, designated Stay Green Rice (SGR), cloned positional cloning strategy...
Abstract Human tubulin beta class IVa (TUBB4A) is a member of the β-tubulin family. In most normal tissues, expression TUBB4A little to none, but it highly expressed in human prostate cancer. Here we show that high levels are associated with aggressive cancers and poor patient survival, especially for African-American men. Additionally, cancer cells, knockout (KO) reduces cell growth migration induces DNA damage through increased γH2AX 53BP1. Furthermore, during constricted migration,...
A remarkable visible-light-promoted photoredox catalytic methodology involved with amines and eco-friendly potassium thioacids for amide formation was uncovered. This approach can mimic the natural coenzyme acetyl-CoA to selectively acylate without affecting other functional groups such as alcohols, phenols, esters, among others. The developed strategy may hold great potential a comprehensive display of biologically interesting peptide synthesis amino acid modification through diacyl...
Epidemiological studies have demonstrated an association between sulfur dioxide (SO2) and increase of morbidity mortality cardiovascular diseases, such as ischemic heart disease, failure, arrhythmia. Mitochondrion is the most sensitive organelle in myocardium animals exposed to SO2. Here we study molecular characterization mitochondrial dysfunction cardiac muscles rat after SO2 exposure. We found that cytochrome c oxidase (COX) activity, membrane potential (ΔΨm), ATP contents, DNA (mtDNA)...
Two novel meroterpenoids, rhodomentones A and B bearing an unprecedented caryophyllene-conjugated oxa-spiro[5.8] tetradecadiene skeleton, were isolated from the leaves of Rhodomyrtus tomentosa. Their structures with unique NMR characteristics determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, quantum molecular calculation, chemical transformation as well total synthesis.
Tomentosenol A (<bold>1</bold>), along with a pair of epimers, 4<italic>S</italic>-focifolidione (<bold>2</bold>) and 4<italic>R</italic>-focifolidione (<bold>3</bold>), were isolated from the leaves <italic>Rhodomyrtus tomentosa</italic>.
Abstract Objective This study intended to establish a droplet digital PCR (dd‐ ) for monitoring minimal residual disease ( MRD in patients with BCR / ABL (P210)‐positive chronic myeloid leukemia CML ), thereby achieving deep‐level of tumor load and determining the efficacy guided clinically individualized treatment. Methods Using dd‐ RT ‐ qPCR , two cell suspensions were obtained from K562 cells normal peripheral blood mononuclear by gradient dilution measured at cellular level. At PB level,...
Driven by bioinspiration and appreciation of their structures, the first biomimetic total syntheses with structural revision acylphloroglucinols myrtucommulone J myrtucommuacetalone, two biologically meaningful natural products, were achieved through a biosynthetic hemiacetalization/dehydration/[3 + 3]-type cycloaddition domino sequence high step efficiency. These result in corrected structure for J.
A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective of phenolic primary aliphatic hydroxyl groups, which greatly expanded the realm protecting group chemistry. The importance reagent also reflected its moisture tolerance, high efficiency, potential in chemistry biologically meaningful natural product modification.
Mitochondrial ferritin (FtMt) is a mitochondrially localized protein possessing ferroxidase activity and the ability to store iron. FtMt overexpression in cultured cells protects against oxidative damage by sequestering redox-active, intracellular Here, we found that acute exhaustive exercise significantly increases expression murine heart. gene disruption decreased exhaustion time altered heart morphology with severe cardiac mitochondrial injury fibril disorganization. The number of...
A remarkable bioinspired EDDA-mediated method for the selective construction of biologically interesting and highly strained bridged methanodibenzo[b,f][1,5]dioxocin flavonoid scaffold was uncovered by starting from a variety readily available acylphloroglucinol 2-hydroxycinnamaldehyde substrates. This merges fascinating olefin isomerization/hemiacetallization/dehydration/[3 + 3]-type cycloaddition cascade reaction driven an in situ generated chromenylium intermediate provides convenient...
Despite recent advancements, the pathogenesis of multiple myeloma (MM) remains incompletely elucidated, with relapse and therapy resistance persisting as major clinical challenges, underscoring imperative to identify novel therapeutic targets. Differentially expressed genes were initially screened from GSE6477 GSE6691 datasets. Subsequent functional annotation pathway enrichment analyses conducted utilizing DAVID bioinformatics platform. A protein-protein interaction network was constructed...
This study investigates the impact of minimal residual disease (MRD) on relapse in patients with acute myeloid leukemia (AML), focusing its interaction immune cells function. A total 49 AML were enrolled this prospective and categorized into four groups: MRD-positive relapse, without MRD-negative relapse. Peripheral blood T lymphocyte subpopulations analyzed using ten-color flow cytometry. CD4+ co-cultured cell lines to assess proliferation, apoptosis, cytokine release. In patients, relapsed...
Acute myeloid leukemia patients with complex karyotype (CK-AML) account for approximately 10–15% of adult AML cases, and are often associated a poor prognosis. Except about 70% CK-AML biallelic inactivation TP53, the leukemogenic mechanism in nearly 30% wild-type TP53 has remained elusive. In this study, 15 cases were screened out 140 de novo expression levels MDM4, main negative regulator p53-signaling pathway, detected. We ruled mutations genes prognosis CK-AML, including RUNX1 or...
To investigate the mechanism of exosomes' role in transformation MDS to AML.Exosomes culture supernatants and AML cell lines, were extracted by ultrafiltration identified three ways: morphology, size, exosome protein surface markers. Exosomes from lines then co-cultured with their impacts on microenvironment, proliferation, differentiation, cycle, apoptosis analyzed CCK-8 assay flow cytometry. Furthermore, exosomes MSC for further authentication.The transmission electron microscopy,...
A new acylphloroglucinol with a novel architecture including an unprecedented dearomatic dibenzofuran core, named callistemenonone (1), was isolated from the leaves of Callistemon viminalis (Myrtaceae). The structure fully characterized on basis extensive spectroscopic analysis, UV, HRESIMS, as well 1D and 2D NMR spectral data (HSQC, HMBC, ROESY). deduced represents first example natural two phenyl moieties coupling through tertiary hydroxy ketal carbons. plausible biogenetic pathway...