A5089738575- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Natural Compound Pharmacology Studies
- Phytochemistry and Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical Studies and Bioactivities
- Bioactive natural compounds
- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Synthesis of Organic Compounds
- Fungal Biology and Applications
- Carbohydrate Chemistry and Synthesis
- Marine Sponges and Natural Products
- Biological and pharmacological studies of plants
- Bioactive Natural Diterpenoids Research
- Pharmacological Effects of Natural Compounds
- Synthetic Organic Chemistry Methods
- Phytochemicals and Antioxidant Activities
- Toxin Mechanisms and Immunotoxins
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- X-ray Diffraction in Crystallography
Chinese Academy of Sciences
2016-2025
South China Botanical Garden
2016-2025
China National Botanical Garden
2022-2025
South China University of Technology
2025
Beijing Botanical Garden
2013-2024
Robert Bosch (Germany)
2021-2023
Institute of Botany
2022
University of Chinese Academy of Sciences
2022
Laboratoire de Chimie Moléculaire et Thioorganique
2021
Weatherford College
2021
Antibiotic resistance is a critical global health care crisis requiring urgent action to develop more effective antibiotics. Utilizing the hydrophobic scaffold of xanthone, we identified three components that mimicked an antimicrobial cationic peptide produce membrane-targeting antimicrobials. Compounds 5c and 6, which contain xanthone core, lipophilic chains, amino acids, displayed very promising activity against multidrug-resistant Gram-positive bacteria, including MRSA VRE, rapid...
This work describes how to tune the amphiphilic conformation of α-mangostin, a natural compound that contains hydrophobic xanthone scaffold, improve its antimicrobial activity and selectivity for Gram-positive bacteria. A series derivatives was obtained by cationic modification free C3 C6 hydroxyl groups α-mangostin with amine different pKa values. Modified structures using moieties high values, such as AM-0016 (3b), exhibited potent properties against Compound 3b also killed bacteria...
Abstract Betulin was convert to betulinic acid using two different synthetic routes. The first approach involved an oxidation of betulin Jones' reagent betulonic and subsequent NaBH4 reduction acid. second steps utilizing protecting groups on the alcohol functional circumvent isomerization secondary
High-performance liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) was applied to the analysis of flavonoids and their glycoside malonates flowers leaves red clover (Trifolium pratense). Through LC-MS comparative studies on plant extracts malonate-free extracts, approximately 20 flavonoid were detected in flower extract. Eight identified as genistin 6' '-O-malonate (39), formononetin 7-O-beta-D-glucoside (40), biochanin A (41), trifoside (42), irilone...
An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by combination 1D- 2D-NMR techniques with aid computer modeling. Nigranoic showed activity in several anti-HIV reverse transcriptase polymerase assays.
A remarkable visible-light-promoted photoredox catalytic methodology involved with amines and eco-friendly potassium thioacids for amide formation was uncovered. This approach can mimic the natural coenzyme acetyl-CoA to selectively acylate without affecting other functional groups such as alcohols, phenols, esters, among others. The developed strategy may hold great potential a comprehensive display of biologically interesting peptide synthesis amino acid modification through diacyl...
Antioxidant activities of wampee peel extracts using five different solvents (ethanol, hexane, ethyl acetate, butanol and water) were determined by in‐vitro antioxidant models including total capability, 1,1‐diphenyl‐2‐picryl hydrazyl (DPPH) radical scavenging activity, reducing power, superoxide activity. Ethyl acetate fraction (EAF) exhibited the highest activity compared to other fractions, even higher than synthetic butylated hydroxyl toluene (BHT). In addition, EAF strong anticancer...
Flavonoids are important bioactive components in Dendrobium officinale, a medicinal orchid. They involved many biological activities, including protecting plants against biotic and abiotic stresses. Research on the key genes related to flavonoid biosynthesis D. officinale is limited. In this study, one of genes, flavanone 3-hydroxylase (F3H), was characterized from officinale. The open reading frame DoF3H 1 134 bp long it encoded 377-amino acid protein. protein showed considerably high...
Abstract Background The auxin indole-3-acetic acid (IAA) is a vital phytohormone that influences plant growth and development. Our previous work showed IAA content decreased during flower development in the medicinally important orchid Dendrobium officinale , while Aux/IAA genes were downregulated. However, little information about auxin-responsive their roles D. exists. Results This study validated 14 DoIAA 26 DoARF early genome. A phylogenetic analysis classified into two subgroups. An of...
Antimalarial bioassay-directed fractionation led to the isolation of a new active indole alkaloid, decursivine (1), from leaves and stems Rhaphidophora decursiva Schott (Araceae). In addition, leaf sample yielded structurally-related compound serotobenine (2), previously reported taxonomically unrelated family, which was not against Plasmodium falciparum. The structure 1 elucidated by spectroscopic means, its antimalarial activity observed with IC 50 values 3.93 4.41µg/ml D6 W2 clones...
The application of a computer-assisted structure elucidation expert system, CISOC–SES, leading to the unequivocal 1H, 13C and NOE resonance assignment betulinic acid, biologically active triterpenoid with complicated NMR resonances, is described. procedure consists peak picking that independent background information, systematic interpretation connectivity information from 2D into bond constraints based on proposed structure. De novo generation solely molecular formula spectral data also...
During a large-scale isolation of the cancer chemopreventive mammalian lignan precursor secoisolariciresinol diglucoside (SDG, 6) from defatted meal flaxseed (Linum usitatissimum L.), new flavonoid, herbacetin 3,8- O -diglucopynanoside (1) was obtained, along with two known flavonoids, 3,7- O- dimethyl ether (3) and kaempferol -diglucopyranoside (4), (-)-pinoresinol (5). The structure -ß-D-diglucopynanoside determined by combination NMR techniques. Further, absolute configuration stereogenic...
Two novel meroterpenoids, rhodomentones A and B bearing an unprecedented caryophyllene-conjugated oxa-spiro[5.8] tetradecadiene skeleton, were isolated from the leaves of Rhodomyrtus tomentosa. Their structures with unique NMR characteristics determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, quantum molecular calculation, chemical transformation as well total synthesis.
Tomentosenol A (<bold>1</bold>), along with a pair of epimers, 4<italic>S</italic>-focifolidione (<bold>2</bold>) and 4<italic>R</italic>-focifolidione (<bold>3</bold>), were isolated from the leaves <italic>Rhodomyrtus tomentosa</italic>.
Tomentodiones A (<bold>1</bold>) and B (<bold>2</bold>), a pair of C-11′ epimers caryophyllene-conjugated phloroglucinols with an unprecedented skeleton, were isolated from the leaves <italic>Rhodomyrtus tomentosa</italic>.