A5054673624- Synthesis and biological activity
- Natural Antidiabetic Agents Studies
- Cholinesterase and Neurodegenerative Diseases
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Enzyme function and inhibition
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Microbial Applications in Construction Materials
- Diet, Metabolism, and Disease
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- Bioactive Compounds and Antitumor Agents
- HIV/AIDS drug development and treatment
- Phytochemicals and Antioxidant Activities
- Cancer therapeutics and mechanisms
- Synthesis of Organic Compounds
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Pesticide Exposure and Toxicity
- Advances in Cucurbitaceae Research
- Natural Compound Pharmacology Studies
Babol University of Medical Sciences
2018-2025
Tehran University of Medical Sciences
2015-2022
Auckland University of Technology
2019
Institute for Health Metrics and Evaluation
2018-2019
University of Washington
2019
Iran University of Medical Sciences
2017
Shahid Beheshti University
2008-2009
BackgroundThe number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding disease burden. We aimed present first detailed analysis global prevalence, mortality, overall burden as captured by Global Burden Diseases, Injuries, Risk Factors (GBD) Study 2016, highlight most important messages for clinicians neurologists.MethodsGBD 2016...
Abstract Coumarins and their derivatives are receiving increasing attention due to numerous biochemical pharmacological applications. In this study, a series of novel coumarin–1,2,3‐triazole‐acetamide hybrids was tested against some metabolic enzymes including α‐glycosidase (α‐Gly), α‐amylase (α‐Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), hCA II. The new showed K i values in the range 483.50–1,243.04 nM I, 508.55–1,284.36 II,...
In this study, novel acridone‐1,2,4‐oxadiazole‐1,2,3‐triazole hybrids were designed, synthesized, and evaluated for their acetylcholinesterase butyrylcholinesterase inhibitory activity. Among various synthesized compounds, 10‐((1‐((3‐(4‐methoxyphenyl)‐1,2,4‐oxadiazol‐5‐yl)methyl)‐1 H ‐1,2,3‐triazol‐4‐yl)methyl)acridin‐9(10 )‐one 10b showed the most potent anti‐acetylcholinesterase activity (IC 50 = 11.55 μ m ) being as rivastigmine. Also docking outcomes in good agreement with vitro results...
Herein, novel coumarin-pyridine derivatives<bold>4a–p</bold>as potent α-glucosidase inhibitors were synthesized by a one-pot and three-component synthesis method.
Abstract In this study, 18 novel quinoline-based-benzo[d]imidazole derivatives were synthesized and screened for their α-glucosidase inhibitory potential. All compounds in the series except 9q showed a significant inhibition with IC 50 values range of 3.2 ± 0.3–185.0 0.3 µM, as compared to standard drug acarbose (IC = 750.0 5.0 µM). A kinetic study indicated that compound 9d most potent derivative against was competitive type inhibitor. Furthermore, molecular docking revealed effective...
Abstract In this work, a novel series of N -phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives 5a–n were designed by consideration the potent α-glucosidase inhibitors containing indole and carboxamide-1,2,3-triazole- -phenylacetamide moieties. These compounds synthesized click reaction evaluated against yeast α-glucosidase. All newly title demonstrated superior potency when compared with acarbose as standard inhibitor. Particularly, compound 5k possessed best inhibitory activity...
Abstract In the present work, a new series of 14 novel phthalimide-benzenesulfonamide derivatives 4a – n were synthesized, and their inhibitory activity against yeast α-glucosidase was screened. The obtained results indicated that most newly synthesized compounds showed prominent α-glucosidase. Among them, 4-phenylpiperazin derivative 4m exhibited strongest inhibition with IC 50 value 52.2 ± 0.1 µM. Enzyme kinetic study compound proved its mode competitive K i this calculated to be 52.7...
Abstract The control of postprandial hyperglycemia is an important target in the treatment type 2 diabetes mellitus (T2DM). As a result, targeting α-glucosidase as most enzyme breakdown carbohydrates to glucose that leads increase one processes T2DM. In present work, new class benzimidazole-Schiff base hybrids 8a–p has been developed based on potent reported inhibitors. These compounds were synthesized by sample recantations, characterized 1 H-NMR, 13 C-NMR, FT-IR, and CHNS elemental...
Aim: A series of 2-benzylidene-benzofuran-3-ones were designed from the structures Ebselen analogs and aurone derivatives synthesized in good yields. Materials & methods: The target compounds prepared by condensation reaction between appropriate benzofuranones with amino alkoxy aldehydes evaluated as cholinesterase inhibitors Ellman's method. Results: vitro anti-acetylcholinesterase (AChE)/butyrylcholinesterase activities revealed that 7e (IC50 = 0.045 μM) is most active compound against...