A5013162407- Natural Antidiabetic Agents Studies
- Synthesis and biological activity
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Enzyme-mediated dye degradation
- Electrochemical sensors and biosensors
- Synthesis and Characterization of Heterocyclic Compounds
- Analytical chemistry methods development
- Advanced Nanomaterials in Catalysis
- Computational Drug Discovery Methods
- Enzyme Catalysis and Immobilization
- Quinazolinone synthesis and applications
- Diet, Metabolism, and Disease
- Psidium guajava Extracts and Applications
- HIV/AIDS drug development and treatment
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Biochemical and Molecular Research
- Bioactive Compounds and Antitumor Agents
- Food Science and Nutritional Studies
- Oral microbiology and periodontitis research
- Advances in Cucurbitaceae Research
- Synthesis of Organic Compounds
- Bacterial biofilms and quorum sensing
Tehran University of Medical Sciences
2019-2025
Biotechnology Research Center
2020-2025
Pharmaceutical Biotechnology (Czechia)
2021
Diabetes mellitus, particularly type 2 diabetes, is a growing global health challenge characterized by chronic hyperglycemia due to insulin resistance. One therapeutic approach managing this condition the inhibition of α-glucosidase, an enzyme involved in carbohydrate digestion, reduce postprandial blood glucose levels. In study, series thiosemicarbazide-linked quinoline-piperazine derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity, identify new agents...
Abstract In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed, synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most active compound in series, 6j (X = 4-bromobenzyl) exhibited significant potency with an IC 50 value of 28.0 ± 0.6 µM compared to acarbose as the positive control 750.0 µM. kinetic study showed a competitive inhibition pattern against derivative. Also, molecular dynamic simulations performed...
In an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a-ag have been synthesized through heating mixture 2-aminobenzimidazoles 1 and α-azidochalcone 2 under the mild conditions. This efficient, facile protocol has resulted into desirable compounds with wide substrate scope in good excellent yields. Afterwards, their inhibitory activities against yeast enzyme were investigated. Showing IC
Abstract In this work, a novel series of cyanoacetohydrazide linked to 1,2,3-triazoles ( 9a – n ) were designed and synthesized be evaluated for their anti-α-glucosidase activity, focusing on the fact that α-glucosidase inhibitors have played significant role in management type 2 diabetes mellitus. All compounds except exhibited excellent inhibitory potential, with IC 50 values ranging from 1.00 ± 0.01 271.17 0.30 μM when compared standard drug acarbose (IC = 754.1 0.5 μM). The kinetic...
Abstract In this study, 18 novel quinoline-based-benzo[d]imidazole derivatives were synthesized and screened for their α-glucosidase inhibitory potential. All compounds in the series except 9q showed a significant inhibition with IC 50 values range of 3.2 ± 0.3–185.0 0.3 µM, as compared to standard drug acarbose (IC = 750.0 5.0 µM). A kinetic study indicated that compound 9d most potent derivative against was competitive type inhibitor. Furthermore, molecular docking revealed effective...
Abstract Diabetes mellitus is a multifactorial global health disorder that rising at an alarming rate. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes to target α-glucosidase, which catalyzes starch hydrolysis in the intestine. In attempt find potential α-glucosidase inhibitors, series of twenty new quinoline linked benzothiazole hybrids ( 8a–t ) were synthesized good yields from suitable reaction procedures and their chemical structures...
Abstract In this work, a novel series of N -phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives 5a–n were designed by consideration the potent α-glucosidase inhibitors containing indole and carboxamide-1,2,3-triazole- -phenylacetamide moieties. These compounds synthesized click reaction evaluated against yeast α-glucosidase. All newly title demonstrated superior potency when compared with acarbose as standard inhibitor. Particularly, compound 5k possessed best inhibitory activity...
Abstract In the present work, a new series of 14 novel phthalimide-benzenesulfonamide derivatives 4a – n were synthesized, and their inhibitory activity against yeast α-glucosidase was screened. The obtained results indicated that most newly synthesized compounds showed prominent α-glucosidase. Among them, 4-phenylpiperazin derivative 4m exhibited strongest inhibition with IC 50 value 52.2 ± 0.1 µM. Enzyme kinetic study compound proved its mode competitive K i this calculated to be 52.7...
Abstract The control of postprandial hyperglycemia is an important target in the treatment type 2 diabetes mellitus (T2DM). As a result, targeting α-glucosidase as most enzyme breakdown carbohydrates to glucose that leads increase one processes T2DM. In present work, new class benzimidazole-Schiff base hybrids 8a–p has been developed based on potent reported inhibitors. These compounds were synthesized by sample recantations, characterized 1 H-NMR, 13 C-NMR, FT-IR, and CHNS elemental...
New series of thioquinoline structures bearing phenylacetamide 9a-p were designed, synthesized and the structure all derivatives was confirmed using different spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, ESI-MS elemental analysis. Next, α-glucosidase inhibitory activities also determined compounds (IC50 = 14.0 ± 0.6-373.85 0.8 μM) more potent than standard inhibitors acarbose 752.0 2.0 against α-glucosidase. Structure-activity relationships (SARs) rationalized by analyzing...
Abstract In an attempt to find novel α -glucosidase inhibitors, efficient, straightforward reaction synthesize a library of fully substituted 6-amino-pyrazolo[1,5- ]pyrimidines 3 has been investigated. Heating mixture α-azidochalcones 1 and 3-aminopyrazoles 2 under the mild condition afforded desired compounds with large substrate scope in good excellent yields. All obtained products were evaluated as inhibitors exhibited potency IC 50 values ranging from 15.2 ± 0.4 µM 201.3 4.2 µM. Among...