A5024536677- Synthesis and biological activity
- Natural Antidiabetic Agents Studies
- Cholinesterase and Neurodegenerative Diseases
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Computational Drug Discovery Methods
- Immune Cell Function and Interaction
- Synthesis and Characterization of Heterocyclic Compounds
- Enzyme function and inhibition
- Diet, Metabolism, and Disease
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Pulmonary Hypertension Research and Treatments
- Microwave-Assisted Synthesis and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Biochemical Analysis and Sensing Techniques
- Phosphodiesterase function and regulation
- Neuroscience and Neuropharmacology Research
- Dyeing and Modifying Textile Fibers
- Psidium guajava Extracts and Applications
Alborz University of Medical Sciences
2018-2024
Biotechnology Research Center
2018-2024
Jahrom University of Medical Sciences
2019-2021
Imam Khomeini Hospital
2021
Usmanu Danfodiyo University
2021
Tehran University of Medical Sciences
2021
Islamic Azad University, Arak
2021
Mazandaran University of Medical Sciences
2021
University of Kara
2019
Abstract Coumarins and their derivatives are receiving increasing attention due to numerous biochemical pharmacological applications. In this study, a series of novel coumarin–1,2,3‐triazole‐acetamide hybrids was tested against some metabolic enzymes including α‐glycosidase (α‐Gly), α‐amylase (α‐Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), hCA II. The new showed K i values in the range 483.50–1,243.04 nM I, 508.55–1,284.36 II,...
Abstract In the present work, a new series of 14 novel phthalimide-benzenesulfonamide derivatives 4a – n were synthesized, and their inhibitory activity against yeast α-glucosidase was screened. The obtained results indicated that most newly synthesized compounds showed prominent α-glucosidase. Among them, 4-phenylpiperazin derivative 4m exhibited strongest inhibition with IC 50 value 52.2 ± 0.1 µM. Enzyme kinetic study compound proved its mode competitive K i this calculated to be 52.7...
Abstract A series of new Schiff bases bearing 1,2,3‐triazole 12a ‒ o was designed, synthesized, and evaluated as α‐glucosidase inhibitors. All the synthesized compounds showed promising inhibition against were more potent than standard drug acarbose. The kinetic study on most compound 12n that this acted a competitive inhibitor. docking revealed interacted with important residues in active site α‐glucosidase.
Abstract Regarding the important role of α-glucosidase enzyme in management type 2 diabetes mellitus, current study was established to design and synthesize aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamide ( 11a – o ) structure all derivatives confirmed through various techniques including IR, 1 H-NMR, 13 C-NMR elemental analysis. Next, inhibitory potentials were evaluated, compounds displayed potent inhibition with IC 50 values range 26.0 ± 0.8–459.8 1.5 µM as...
Abstract Background The prominent efficacy in terms of increasing progression-free survival (PFS) Daratumumab, Lenalidomide and dexamethasone (DRd) triplet therapy versus Carfilzomib, (KRd) was proven previously relapsed-refractory multiple myeloma (RRMM). However, the cost effectiveness DRd KRd is unknown. Methods We developed a Markov model by using an Iranian payer perspective 10-year time horizon to estimate healthcare cost, Quality-adjusted life years (QALYs) gain (LYG) for therapies....
Abstract In pursuit of developing novel cholinesterase (ChE) inhibitors through molecular hybridization theory, a series isoindolin-1,3-dione-based acetohydrazides (compounds 8a – h ) was designed, synthesized, and evaluated as possible acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inhibitors. vitro results revealed IC 50 values ranging from 0.11 ± 0.05 to 0.86 0.02 µM against AChE 5.7 0.2 30.2 2.8 BChE. A kinetic study conducted on the most potent compound, , ascertain its mode...
A novel catalyst is synthesized based on the immobilization of palladium γ-Fe<sub>2</sub>O<sub>3</sub>@SiO<sub>2</sub>–(CH<sub>2</sub>)<sub>3</sub>–PDTC nanoparticles and used as a highly active for Heck/Sonogashira coupling reactions.
A series of novel 4-phenylpiperazine-carbodithioate-N-phenylacetamide hybrids (6a-n) was designed, synthesized, and evaluated for their in vitro inhibitory activity against the metabolic enzymes, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase. The obtained results showed that most synthesized compounds exhibited high to good anti-AChE anti-BChE range nanomolar concentrations comparison tacrine as a positive control. Molecular modeling potent 6e 6i demonstrated these...