A5085248435- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Memory and Neural Mechanisms
- Domain Adaptation and Few-Shot Learning
- Neural dynamics and brain function
- Memory Processes and Influences
- Neuroscience and Music Perception
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Child and Animal Learning Development
- Neural and Behavioral Psychology Studies
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Biopolymer Synthesis and Applications
- Innovative Teaching and Learning Methods
- Autophagy in Disease and Therapy
New York University
2020-2024
Tongliao Academy of Agricultural Sciences
2024
Fudan University
2009-2021
State Key Laboratory of Medical Neurobiology
2018-2021
Peking University
2016-2021
Chengdu University of Traditional Chinese Medicine
2020
Nanjing Normal University
2020
Southern University of Science and Technology
2017
Huashan Hospital
2009
Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which due to lack of comprehensive neuroprotective effects. Herein, macrophage-disguised honeycomb manganese dioxide (MnO2 ) nanosphere loaded with fingolimod (FTY) developed salvage penumbra. In particular, biomimetic nanoparticles can accumulate actively damaged brain via macrophage-membrane protein-mediated...
Reperfusion injury exists as the major obstacle to full recovery of neuron functions after ischemic stroke onset and clinical thrombolytic therapies. Complex cellular cascades including oxidative stress, neuroinflammation, brain vascular impairment occur within neurovascular units, leading microthrombus formation ultimate death. In this work, a multitarget micelle system is developed simultaneously modulate various cell types involved in these events. Briefly, rapamycin encapsulated...
Abstract Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on β‐amyloid (Aβ) targeting. However, such have limited clinical outcomes due to the chronic and irreversible impairment of nervous system in late stage AD. Recently, inflammatory responses, manifested oxidative stress glial cell activation, been reported as hallmarks early stages Based crosstalk between response brain cells, a reactive oxygen species (ROS)‐responsive dendrimer–peptide conjugate...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancy, with an only 6% 5-year relative survival rate. The dismal therapeutic effect attributed to chemotherapy resistance and unique pathophysiology abundant inflammatory cytokines abnormal hyperplasia extracellular matrix (ECM). Based on theory that bone marrow mesenchymal stem cells (BM-MSCs) can influence tumorous microenvironment malignant growth PDAC, we employed exosomes (Exos) derived from BM-MSCs as...
Anticancer therapies, which can induce cell death and elevate antitumor immune response in the meantime, are considered as effective treatments for many types of cancers. Immunogenic (ICD) induced by chemodrugs is a promising typical strategy to achieve cytotoxicity immunological enhancement together. However, due low level ICD induction less tumor-targeting accumulation, application traditional inducers limited. Here, core-shell magnetic nanoparticles (ETP-PtFeNP:α-enolase targeting peptide...
Metabolic interactions between different cell types in the tumor microenvironment (TME) often result reprogramming of metabolism to be totally from their normal physiological processes order support growth. Many studies have attempted inhibit growth and activate immunity by regulating tumors other cells TME. However, metabolic inhibitors suffer heterogeneity tumors, since favorable regulation malignant TME is inconsistent with each other. Therefore, we reported design a pH-sensitive drug...
Lack of tumor-infiltration lymphocytes (TILs) and resistances by overexpressed immunosuppressive cells (principally, myeloid-derived suppressor (MDSCs)) in tumor milieu are two major challenges hindering the effectiveness immunotherapy for "immune-cold" tumors. In addition, natural physical barrier existing solid cancer also limits deeper delivery drugs. Here, a tumor-targeting light-responsive-penetrable nanoplatform (Apt/PDGs
Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive malignancies due to its unique microenvironment which cardinal histopathological feature remarkable desmoplasia stroma, taking up about 80% tumor mass. The desmoplastic stroma negatively affects drug diffusion and infiltration T cells, leading an immunosuppressive microenvironment. However, this can limit physical spread pancreatic cancer via a neighbor suppression effect. Here, central targeting responsive...
Abstract The frequent relapse and metastasis characteristics of triple negative breast cancer (TNBC) make it a fraught issue with very poor prognosis in clinic. An effective treatment for TNBC should prevent even eliminate as well suppress primary lesion expansion. Recent progress reveals that platelets can be recruited activated by tumor cells through intercellular adhesion molecules (ICAM), help aggressive circulating (CTCs) form metastasis. Therefore, are considered possession...
The chromanone scaffold is a privileged structure in heterocyclic chemistry and drug discovery. A highly efficient copper-catalyzed asymmetric conjugated reduction of chromones developed to give chiral chromanones with good yields (80-99%) excellent ee values (94->99% ee). Particularly noteworthy that thiochromanones are also constructed using this method 74-87% 96-97% ee. established synthesis paves the way for their further pharmaceutical studies.
Abstract Episodic memory retrieval is increasingly influenced by schematic information as memories mature, but it unclear whether this due to the slow formation of schemas over time, or forgetting episodes. To address this, we separately probed for newly learned well their influence on episodic decisions. In experiment, participants encoded images from two categories, with location in each category drawn a different spatial distribution. They could thus learn locations encoding specific We...
Are associative memories forgotten more quickly than item memories, and does the level of original learning differentially influence forgetting rates? In this study, we addressed these questions by having participants learn single words word pairs once (Experiment 1), three times 2), six 3) in a massed (ML) or distributed (DL) mode. Then they were tested for recognition separately after four retention intervals: 10 min, 1 d, wk, mo. The contribution recollection familiarity processes...
Efficient removal of deadly toxicants by blood purification remains predominant in poisoning treatment. Current strategies mainly rely on absorptive scavengers that normally have no selectivity to the adsorbates, which could result poor clinical outcomes certain toxic species due passivity and inaccuracy detoxification procedure. Herein, a positive, accurate, customized strategy was proposed. Based sophisticated molecule design thoughtful structure analysis aimed toxicant paraquat,...
Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved tumor initiation, progression, invasion and metastasis several cancers. The delivery anti-miR21 sequences has significant potential for treatment. Nevertheless, since extremely unstable they need to obtain certain concentration function, it intensely difficult build an effective system them. purpose this work construct self-assembled glutathione...
Abstract Many of the sensations experienced by an organism are caused their own actions, and accurately anticipating both sensory features timing self-generated stimuli is crucial to a variety behaviors. In auditory cortex, neural responses sounds exhibit frequency-specific suppression, suggesting that movement-based predictions may be implemented early in processing. Yet it remains unknown whether this modulation results from behaviorally specific temporally precise prediction, nor known...
Abstract The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate effective treatment. Herein, an mild local treatment strategy is developed that regulates the microenvironment delays GBM recurrence. Briefly, injectable hydrogel system (imGEL) loaded with Zn(II) 2 ‐AMD3100 (AMD‐Zn) CpG oligonucleotide nanoparticles (CpG NPs) injected into operation cavity, long‐term function to block recruitment microglia/ macrophages activate cytotoxic...
As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization withstand harsh conditions. Several approaches been explored inhibit the growth and metastasis of by disrupting reprogrammed metabolism. However, limitations within solid tumors may induce metabolic flexibility malignant sustain survival using one fill metabolite pools normally supplied other. To overcome this predicament, promising click-nucleic-acid-containing platform for codelivery rapamycin, anti-PFKFB4...
Episodic memory retrieval is increasingly influenced by schematic information as memories mature, but it unclear whether this due to the slow formation of schemas over time, or decay episodes. To address this, we separately probed for newly learned well their influence on episodic decisions. In experiment, participants encoded images from two categories, with location in each category drawn a different spatial distribution. They could thus learn locations encoding specific We found that were...