A5022719051- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Axial and Atropisomeric Chirality Synthesis
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Synthesis of Organic Compounds
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis of Indole Derivatives
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Carbohydrate Chemistry and Synthesis
- Molecular spectroscopy and chirality
- Organoboron and organosilicon chemistry
- Multicomponent Synthesis of Heterocycles
- Catalytic Cross-Coupling Reactions
- Organophosphorus compounds synthesis
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Gaze Tracking and Assistive Technology
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Emotion and Mood Recognition
- Chemical Synthesis and Reactions
Hong Kong Baptist University
2012-2025
Guangdong Academy of Sciences
2025
Institute of Zoology
2025
Southern University of Science and Technology
2014-2023
Hong Kong Polytechnic University
2009-2023
Southwest Medical University
2023
Xinjiang University
2021
First Affiliated Hospital of Anhui Medical University
2020
Anhui Medical University
2020
State Council of the People's Republic of China
2019
Steering together all four Ugi pieces The nearly 60-year-old reaction is a remarkably efficient means of linking molecular building blocks: an aldehyde, amine, carboxylic acid, and isocyanide. Because each component independently tunable, the especially well suited to assembly diverse compound libraries. However, stereoselectivity has been challenge. Zhang et al. now show that chiral phosphoric acids can catalyze four-component coupling with high enantioselectivity (see Perspective by Riva)....
Go forth and make bonds: The aza-Michael addition is an excellent way of forming CN bonds tremendous significance in asymmetric synthesis. Recently, impressive progress has been achieved by employing new nitrogen nucleophiles, suitable acceptors, more efficient catalyst systems for this important transformation. This review surveys the advances among intermolecular- intramolecular domino reactions involved developed between 2010 early 2012.
Leicht zugänglich ist ein chiraler Iridium-(H8-Binapo)-Katalysator, der die hoch enantioselektive Hydrierung von Chinoxalinen bei hohen Substrat/Katalysator-Verhältnissen 100 bis 20 000 vermittelt. Die neue Methode dient als praktischer Ansatz für Synthese optisch aktiver Tetrahydrochinoxalin-Derivate (siehe Schema; cod=1,5-Cyclooctadien).
Abstract Axially chiral arylpyrroles are key components of pharmaceuticals and natural products as well catalysts ligands for asymmetric transformations. However, the catalytic enantioselective construction optically active remains a formidable challenge. Here we disclose highly efficient strategy to access enantioenriched axially by means organocatalytic atroposelective desymmetrization kinetic resolution. Depending on remote control catalyst, were obtained in high yields excellent...
A catalytic enantioselective synthesis of <italic>P</italic>-stereogenic alkenylphosphinates is developed through asymmetric hydrophosphorylation. This process demonstrated on racemic phosphinates and leads to diverse directly.
Asymmetric hydrophosphination is the most atomically economical and straightforward approach to construction of chiral organophosphorus compounds. Good stereoselectivities have been achieved in asymmetric an electron-deficient C═C double bond, but substrates involving nonpolar bonds remain difficult are rarely tackled. Herein, we report a non-electronically activated bond with remarkably high degree stereocontrol. This strategy offered expedient broadly applicable platform prepare tertiary...
Abstract A Pd‐catalyzed hydrophosphinylation of alkyl and aryl‐oxyallenes with phosphine oxides has been developed for the efficient rapid construction a family chiral allylic diverse range functional groups. This methodology was further applied in facile 2 H ‐chromene later stage functionalization cholesterol.
Abstract A Cu/CPA co‐catalytic system has been developed for achieving the direct hydrophosphinylation of alkynes with phosphine oxides in delivering novel axially chiral phosphorus‐containing alkenes high yields and excellent enantioselectivities (up to 99 % yield ee). DFT calculations were performed elucidate reaction pathway origin enantiocontrol. This streamlined modular methodology establishes a new platform design application styrene‐phosphine ligands.
Transition metal-catalyzed hydrofunctionalization of methylenecyclopropanes (MCPs) has presented a considerable challenge due to the difficult manipulation regioselectivity and complicated reaction patterns. Herein, we report straightforward Pd-catalyzed ring-opening hydrophosphinylation MCPs via highly selective C-C bond cleavage. This method allows for rapid efficient access wide range chiral allylic phosphine oxides in good yields high enantioselectivities. Additionally, density...
An enantioselective hydrophosphination of alkenyl isoquinolines is developed by using a copper-chiral diphosphine ligand catalyst. It provides direct and atom-efficient approach to prepare variety chiral phosphines with an isoquinoline unit in good yields high enantioselectivities. In addition, these phosphine products are useful bidentate P,N-ligands which showed potential application asymmetric catalysis.
Abstract Chiral 1, n‐bis(boronate) plays a crucial role in organic synthesis and medicinal chemistry. However, their catalytic asymmetric has long posed challenge terms of operability accessibility from readily available substrates. The recent discovery the C═C bond formation through β‐C elimination methylenecyclopropanes (MCP) provided an exciting opportunity to enhance molecular complexity. In this study, catalyzed cascade hydroboration MCP is developed. By employing different ligands,...
Although enantioselective hydrofunctionalizations of nitrones are established for synthesis various types chiral hydroxylamines, the asymmetric catalytic hydrophosphinylation remains highly challenging. Herein, an efficient of...
Reactions of a range the readily prepared and sterically tunable N,N'-bis(aryl)formamidines with lanthanoid metals bis(pentafluorophenyl)mercury (Hg(C6F5)2) in THF have given an extensive series tris(formamidinato)lanthanoid(III) complexes, [Ln(Form)3(thf)n], namely [La(o-TolForm)3(thf)2], [Er(o-TolForm)3(thf)], [La(XylForm)3(thf)], [Sm(XylForm)3], [Ln(MesForm)3] (Ln=La, Nd, Sm Yb), [Ln(EtForm)3] Sm, Ho [Ln(o-PhPhForm)3] Er). [For explanation N,N'-bis(aryl)formamidinate abbreviations used...
Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to β-phthaliminoacrylate esters took place efficiently give high yields β-aryl-β-amino acid with 96−99% enantioselectivity, which was realized by use a hydroxorhodium/chiral diene complex.
A novel difunctionalization reaction is described. It uses N-trifluoromethylthio-4-nitrophthalimide as the reagent, which serves both nitrogen and SCF3 sources. In presence of DABCO (1,4-diazabicyclo[2.2.2]octane), groups can be incorporated into α,β-unsaturated carbonyl compounds easily give versatile β-amino ketones esters in good yields. This features mild conditions, high atom-economy, efficient access to α-SCF3 amino acids.
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total 1 was accomplished in 7 steps and 38% overall yield aided by the development innovative, sequential strategy involving Pd-catalyzed pyridinium C-H arylation Ir-catalyzed hydrogenation resulting fused tricyclic indenopyridinium salt highlighted use a unique P,N-ligand (MeO-BoQPhos) 1000 ppm...
The chromanone scaffold is a privileged structure in heterocyclic chemistry and drug discovery. A highly efficient copper-catalyzed asymmetric conjugated reduction of chromones developed to give chiral chromanones with good yields (80-99%) excellent ee values (94->99% ee). Particularly noteworthy that thiochromanones are also constructed using this method 74-87% 96-97% ee. established synthesis paves the way for their further pharmaceutical studies.
Abstract Chiral chromene motifs are important heterocycles in numerous natural products and bioactive molecules. Among them, flavenes, flavanes, flavanones, which consist of the 2‐aryl‐chromene skeleton observed most frequently. As subgroups flavonoids, they often occur various plants show many biological activities, such as antitumor, antioxidant, antibacterial, anti‐inflammatory, anticoagulant properties. This Minireview summarizes recent reports on catalytic asymmetric synthesis flavanones.
A direct C(sp2)–H thiolation of aromatic amides with disulfides was developed. The coupling reaction proceeds between the thioether radical and cobaltacycle intermediate. This method exhibits a relatively broad substrate scope high functional group compatibility. mechanistic study indicates that cobalt(IV) intermediate is probably formed during course reaction. product can be transformed to Quetiapine, which an atypical antipsychotic agent approved for treatment schizophrenia bipolar disorder.
Abstract Despite the widespread existence of chiral 1,4‐diamines in bioactive molecules and their applications asymmetric catalysis, catalytic synthesis such structures from readily accessible substrates remains a long‐standing challenge. Here, we report Cu‐catalyzed cascade hydroamination protocol to construct wide range 1,4‐diamine derivatives high yields with excellent enatioselectivities (up 95 % yield up >99 ee). The use two hydroxylamine esters containing different functionalized...