A5101532081- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Wound Healing and Treatments
- Transition Metal Oxide Nanomaterials
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Viral Infections and Immunology Research
- Conducting polymers and applications
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- RNA Interference and Gene Delivery
- Diet, Metabolism, and Disease
- Carcinogens and Genotoxicity Assessment
- Circular RNAs in diseases
- Diabetic Foot Ulcer Assessment and Management
- Aerogels and thermal insulation
- Advanced Sensor and Energy Harvesting Materials
Nanjing University
2019-2025
Nanjing Medical University
2019-2024
Changchun University of Science and Technology
2022-2024
Union Hospital
2019-2024
Huazhong University of Science and Technology
2016-2024
Heilongjiang University of Chinese Medicine
2024
Zhejiang University
2014-2023
Zhejiang Lab
2023
Suzhou Traditional Chinese Medicine Hospital
2023
Nanjing University of Chinese Medicine
2023
Highly sensitive photodetection even approaching the single-photon level is critical to many important applications. Graphene-based hybrid phototransistors are particularly promising for high-sensitivity because they have high photoconductive gain due mobility of graphene. Given their remarkable optoelectronic properties and solution-based processing, colloidal quantum dots (QDs) been preferentially used fabricate graphene-based phototransistors. However, resulting QD/graphene face challenge...
Clinical work and research on diabetic wound repair remain challenging globally. Although various conventional dressings have been continuously developed, the efficacy is unsatisfactory. The effect of drug delivery limited by depth penetration. sustained release biomolecules from biological a promising treatment approach to healing. An assortment cell-derived exosomes (exos) proved be instrumental in tissue regeneration, researchers are dedicated developing carriers with unique properties....
The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. impaired angiogenesis phase during healing partly contributes to pathological process. MicroRNA (miRNA) is an essential regulator gene expression in crucial biological processes and promising nucleic acid drug therapeutic fields wound. However, miRNA therapies have limitations due lacking effective delivery system. In present study, we found significant reduction miR-31-5p full-thickness...
Abstract Human adipose‐derived stem cells (ASCs) have a potential for the treatment of peripheral nerve injury. Recent studies demonstrated that can mediate therapeutic effect by secreting exosomes. We aimed to investigate human ASCs derived exosomes (ASC‐Exos) on regeneration in vitro and vivo. Our results showed after being internalized Schwann (SCs), ASC‐Exos significantly promoted SC proliferation, migration, myelination, secretion neurotrophic factors upregulating corresponding genes...
Rationale: Peripheral nerve injury is common in clinic, which leads to severe atrophy and dysfunction of the denervated muscles, but underlying mechanism not fully understood. Recent studies advanced causative role mitochondrial muscle atrophy, while upstream triggers remained unclear. Methods: In present study, Atrophy gastrocnemius tibialis anterior (TA) were evaluated mice sciatic transection model. Transmission electron microscopy (TEM) was then used observe microstructure atrophic...
Abstract Porous metal–organic framework (MOF) liquids with permanent porosity, good fluidity, and fine dispersion attract broad attention in catalysis, transportation, gas storage, chemical separations. Yet, the design synthesis of porous MOF for drug delivery remain less explored. Herein, a simple general strategy is reported to prepare ZIF‐91 liquid (ZIF‐91‐PL) via surface modification ion exchange. The cationic nature ZIF‐91‐PL not only renders it antibacterial but also high curcumin...
Abstract Spinal cord injury (SCI) often leads to cell death, vascular disruption, axonal signal interruption, and permanent functional damage. Currently, there are no clearly effective therapeutic options available for SCI. Considering the inhospitable SCI milieu typified by ischemia, hypoxia, restricted neural regeneration, a novel injectable hydrogel system containing conductive black phosphorus (BP) nanosheets within lipoic acid‐modified chitosan matrix (LAMC) is explored. The...
Non-healing trauma, with limited treatment options, remains a prevalent complication of diabetes mellitus. The underlying causes wherein include oxidative stress injury, bacterial infection, cellular dysfunction, and persistent inflammation. Acellular Dermal Matrix (ADM), wound dressing composed natural extracellular matrix abundant bioactive factors, has been successfully developed to treat various wounds, including burns diabetic ulcers. Protocatechualdehyde (PA) & trivalent iron ion...
4-Nonylphenol (NP) is a ubiquitous environmental chemical with estrogenic activity. Our aim was to test the hypothesis that pubertal exposure NP leads testicular dysfunction. Herein, 24 7-week-old rats were randomly divided into four groups and treated (0, 25, 50, or 100 mg/kg body weight every 2 days for 20 consecutive days) by intraperitoneal injection. Compared untreated controls, parameters of sperm activation rate, curvilinear velocity, average path swimming velocity significantly lower...
Rationale: Antiretroviral therapy can effectively suppress HIV-1 replication in the peripheral blood to an undetectable level. However, elimination of latent virus reservoirs remains a challenge and is major obstacle treatment HIV-1-infected patients. Exosomes exhibit huge promise as endogenous drug delivery nanosystem for delivering drugs solid tissues given their unique properties, including low immunogenicity, innate stability, high efficiency, most importantly ability penetrate due...
Signal transducer and activator of transcription 3 (STAT3) is a multifunctional factor that regulates inflammation immunity. Knowledge its regulatory mechanisms very limited. Here, we showed enterovirus 71 (EV71) infection induced the phosphorylation STAT3 expression downstream inflammatory regulators. Knockdown with siRNAs significantly restricted viral RNA protein levels, also reduced titers. With further investigation, found importin α family member Karyopherin-α1 (KPNA1) was employed by...
Abstract Background Mesenchymal stem cells including adipose-derived (ASCs) have a considerable potential in the field of translational medicine. Unfortunately, multiple factors (e.g., older age, co-existing diabetes, and obesity) may impair cellular function, which hinders overall effectiveness autologous cell therapy. Noncoding RNAs—including microRNAs (miRNAs), long ncRNAs (lncRNAs), circular RNAs (circRNAs)—have been shown to play important roles biology. However, diabetes-related...
Abstract Denervation of skeletal muscles results in a rapid and programmed loss muscle size performance, termed atrophy, which leads to poor prognosis clinical nerve repair. Previous researches considered this process result multiple factors, such as protein homeostasis disorder, mitochondrial dysfunction, endoplasmic reticulum stress (ERS), apoptosis, while their intrinsic association remains be explored. In study, Sestrin2 (SESN2), stress-inducible protein, was shown act key protective...
Monodisperse indium tin oxide nanoparticles (ITO NPs) with high crystallinity have been synthesized by the rapid thermal injection method and seed-mediated growth method. We demonstrate that surface plasmon resonance (SPR) frequencies of ITO NPs can be manipulated from 1,600 to 1,993 nm in near-infrared band controlling composition, size, morphology. The doping Sn concentration could controlled via changing %Sn initial feed 0% 30%. shortest SPR wavelength at 10% indicates highest free...
More studies that are focused on the bioeffects of radio-frequency (RF) electromagnetic radiation is generated from communication devices, but there were few reports with confirmed results about RF reproductive cells. To explore effects 1950 MHz (EMR) mouse Leydig (TM3) TM3 cells irradiated or sham-irradiated continuously for 24 h by specific absorption rate (SAR) 3 W/kg radiation. At 0, 1, 2, 3, 4, and 5 days after irradiation, cell proliferation was detected counting kit-8 (CCK-8) method,...
ABSTRACT Enterovirus 71 (EV71) infection poses a global public health challenge, especially in infants and young children, with severe cases leading to fatal consequences. EV71 modulates various biological processes of the host evades immunity through multiple mechanisms. The balance mitochondrial dynamics is important for cellular homeostasis. However, mechanisms underlying EV71‐induced damage via mitophagy remain unclear. In current study, we showed that significantly reduced total ATP...
Radiation detection and protection are gaining increased importance due to the widespread applications of radiation technology in industry human health, especially for x-rays. However, is usually indirect...