A5079229090- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Advancements in Transdermal Drug Delivery
- Research on Leishmaniasis Studies
- Toxin Mechanisms and Immunotoxins
- Nanoparticle-Based Drug Delivery
- Heavy Metal Exposure and Toxicity
- Sulfur Compounds in Biology
- Crystallization and Solubility Studies
- Pharmaceutical studies and practices
- Essential Oils and Antimicrobial Activity
- Pharmaceutical Practices and Patient Outcomes
- Analytical Chemistry and Chromatography
- Insect and Pesticide Research
- Bee Products Chemical Analysis
- Metal complexes synthesis and properties
- Organometallic Compounds Synthesis and Characterization
- Trace Elements in Health
- RNA Interference and Gene Delivery
- X-ray Diffraction in Crystallography
- Cardiac and Coronary Surgery Techniques
- Advanced Statistical Methods and Models
- Mercury impact and mitigation studies
- Lipid Membrane Structure and Behavior
Quaid-i-Azam University
2016-2025
Tianjin University
2023-2025
Iqra University
2025
Islamia College University
2021-2024
Tabba Heart Institute
2011-2023
Riphah International University
2018-2022
GTx (United States)
2020
King Khalid University
2020
Northwest General Hospital and Research Center
2019
University College of Islamabad
2019
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments offer many valuable opportunities in delivery. Chlorpromazine, an antipsychotic agent with poor aqueous solubility—with extensive first-pass metabolism—can be a suitable candidate for development SNEDDS. The current study was designed to develop triglyceride-based SNEDDS chlorpromazine achieve improved solubility, stability, oral...
Resveratrol (RES) is a naturally existing polyphenol which exhibits anti-oxidant, anti-inflammatory, and anti-cancer properties. In recent years, RES has attracted attention for its synergistic effect with other drugs the treatment of drug resistant cancers. However, faces issues poor pharmacokinetics, stability low solubility limits clinical application. present study, been loaded onto uniformly sized (~60 nm) mesoporous silica nanoparticles (MSNs) to improve in vitro anti-proliferative...
Topical drug delivery against cutaneous leishmaniasis (CL) signifies an effective alternate for improving the availability and reducing toxicity associated with parenteral administration of conventional sodium stibogluconate (SSG) injection. The basic aim study was to develop nano-deformable liposomes (NDLs) dermal SSG CL. NDLs were formulated by a modified thin film hydration method optimized via Box-Behnken statistical design. physicochemical properties SSG-NDLs established in terms...
Chronic wound infections have become a challenging problem due to escalating antibiotic resistance and lack of viable delivery approaches. Carvacrol (CAR) has been reported be effective against multidrug resistant pathogens. In this study, CAR was formulated into site-specific nanoparticle (NP) system using poly(caprolactone) (PCL) achieve sustained antimicrobial effect at infection sites. These NPs were further incorporated dissolving microneedles (MNs) facilitate painless application...
Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems composed cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone research with speedy developments taking place on a daily basis. An incredible amount focus is placed...
Herein, we demonstrate the role of surface modification nanocarriers on their ability to load and protect sensitive payloads.
The purpose of this study was to develop novel carbopol-based miltefosine-loaded transfersomal gel (HePCTG) for the treatment cutaneous leishmaniasis (CL) via efficient targeting leishmania infected macrophages.Miltefosine-loaded transfersomes (HePCT) were prepared by ethanol injection method followed their incorporation into carbopol form HePCTG. HePCT assessed physicochemical properties including mean particle size, polydispersity index, zeta potential, entrapment efficiency, morphology,...
Topical drug delivery is preferable route over systemic in case of Cutaneous leishmaniasis (CL). Among the available agents, amphotericin B (AmB) and pentamidine (PTM) showed promising result against CL. However, monotherapy associated with incidences reoccurrence resistance. Combination therapy therefore recommended. Thin film hydration method was employed for B-pentamidine loaded niosomes (AmB-PTM-NIO) preparation followed by their incorporation into chitosan gel. The optimization...
Graphical representation of green synthesis PdNPs and their biological catalytic applications.
Aim: In this study, the targeting of rifampicin (RIF)-loaded nanotransfersomes (NTs) incorporated in chitosan gel for leishmania-infected macrophages via topical route was investigated. Materials & methods: NTs were prepared through a thin-film hydration process and into gel. Results: The mean particle size 190 nm, with 83% encapsulation efficiency. permeation rate threefold higher than that RIF solution. improved cellular internalization passive targeting, which confirmed by macrophage...
Topical delivery is preferable over systemic for cutaneous leishmaniasis, because of its easy administration, reduced adverse effects and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites the potential to avoid drug resistance developed by enzymatic mutations. NTZ oral formulation associated with severe dyspepsia stomach pain. Herein, NTZ-transethosomes (NTZ-TES) were prepared loaded into chitosan gel (NTZ-TEG) topical delivery. NTZ-TES thin-film hydration...