A5053445061- RNA and protein synthesis mechanisms
- Analytical Methods in Pharmaceuticals
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Nanoparticles: synthesis and applications
- RNA modifications and cancer
- Curcumin's Biomedical Applications
- Computational Drug Discovery Methods
- Electrospun Nanofibers in Biomedical Applications
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Immune Response and Inflammation
- Antibiotics Pharmacokinetics and Efficacy
- Genomics and Phylogenetic Studies
- Nanoparticle-Based Drug Delivery
- Carbon and Quantum Dots Applications
- Alzheimer's disease research and treatments
- Respiratory Support and Mechanisms
- Nanocomposite Films for Food Packaging
- Chronic Myeloid Leukemia Treatments
- Crystallization and Solubility Studies
- Mesenchymal stem cell research
- Phytochemistry and Bioactive Compounds
- MicroRNA in disease regulation
- Phytochemical Studies and Bioactivities
King Khalid University
2021-2025
King Saud University
2022
Topical drug delivery is preferable route over systemic in case of Cutaneous leishmaniasis (CL). Among the available agents, amphotericin B (AmB) and pentamidine (PTM) showed promising result against CL. However, monotherapy associated with incidences reoccurrence resistance. Combination therapy therefore recommended. Thin film hydration method was employed for B-pentamidine loaded niosomes (AmB-PTM-NIO) preparation followed by their incorporation into chitosan gel. The optimization...
Background: Ovarian cancer, colloquially termed the “silent killer” among gynecological malignancies, remains elusive due to its often-asymptomatic progression and diagnostic challenges. Central pathogenesis is overactive PI3K/Akt/mTOR signaling pathway, responsible for various cellular functions, from proliferation survival. Within this context, phytochemical compounds mangiferin (derived Mangifera indica ) curcumin (from Curcuma longa stand out their potential modulatory effects. However,...
ABSTRACT In this study, a sensitive and selective spectrofluorimetric method was developed for the determination of antidiabetic drug nateglinide based on its reaction with xanthene dye acid red 87 (AR87). A fluorescence quenching process observed AR87 at 545 nm upon addition nateglinide, which exploited quantitative analysis. The mechanism investigated using quantum mechanical calculations suggesting transfer between electron‐rich electron‐deficient nateglinide. Additionally, stoichiometry...
Green synthesis of silver nanoparticles (AgNPs) was synthesized from fresh garlic extract coupled with isoniazid hydrazide (INH), a commonly used antibiotic to treat tuberculosis. A molecular docking study conducted the selected compounds compared anthranilate phosphoribosyltransferase (trpD) Mycobacterium The aqueous prepared and mixed nitrate (AgNO3) solution for superfast stable AgNPs. INH then conjugated AgNPs at different ratios (v/v) obtain INH-AgNPs conjugates (AgNCs). resulting AgNCs...
The rapid spread of a novel coronavirus known as SARS-CoV-2 has compelled the entire world to seek ways weaken this virus, prevent its and also eliminate it. However, no drug been approved treat COVID-19. Furthermore, receptor-binding domain (RBD) on viral spike protein, well several other important parts have recently undergone mutations, resulting in new virus variants. While treatment is currently available, naturally derived molecule with antiviral properties could be used potential...
The novel itraconazole (ITZ) nail penetration enhancing self-emulsifying nanovesicles (ITZ-nPEVs) loaded in carboxymethyl fenugreek gum (CMFG) gel circumvent the systemic onychomycosis treatment. ITZ-nPEVs were prepared by thin film hydration technique, and particle size (PS), zeta potential (ZP), drug content (DC), entrapment efficiency (% EE), deformity index (DI), viscosity, morphology, physical stability of measured. In terms hydration, transungual absorption, antifungal efficacy against...
Foot ulceration is one of the most severe and debilitating complications diabetes, which leads to cause non-traumatic lower-extremity amputation in 15-24% affected individuals. The healing diabetic foot (DF) a significant therapeutic problem due from multifactorial process. Electrospun nanofibrous scaffold loaded with various wound dressing materials has excellent properties its multifunctional action.This work aimed develop characterize chitosan (CS)-polyvinyl alcohol (PVA) blended...
The aim of this study was to transform human hair keratin waste into a scaffold for soft tissue engineering heal wounds. extracted using the Shindai method. Keratin and polyvinyl alcohol (PVA) cross-linked with alginate dialdehyde converted by freeze-drying method gentamycin sulphate (GS) as model drug. subjected Fourier infrared spectra (FTIR), swelling index, porosity, water absorption, scanning electron microscopy (SEM), differential calorimetry (DSC), thermal gravimetric analysis (TGA),...
Ebola virus disease (EVD) causes outbreaks and epidemics in West Africa that persist until today. The envelope glycoprotein of (GP) consists two subunits, GP1 GP2, plays a key role anchoring or fusing the to host cell its active form on virion surface. Toremifene (TOR) is ligand mainly acts as an estrogen receptor antagonist; however, recent study showed strong efficient interaction with GP. In this context, we aimed evaluate energetic affinity features involved between GP toremifene by...
Abstract Gastric cancer is considered a class 1 carcinogen that closely linked to infection with Helicobacter pylori ( H. ), which affects over million people each year. However, the major challenge fight against and its associated gastric due drug resistance. This research gap had led our team investigate potential candidate targeting ‐carcinogenic TNF‐alpha‐inducing protein. In this study, total of 45 daidzein derivatives were investigated best 10 molecules comprehensively using in silico...
Herein, zinc oxide nanoparticles (ZnO NPs) were greenly synthesized from Tridax procumbens aqueous leaf extract (TPE) and characterized physically (e.g., Fourier-transform infrared (FTIR) spectroscopy scanning electron microscopy (SEM)) biologically (test of their anti-diabetic activity). Anti-diabetic activities TPE TPE-derived ZnO NPs have been carried out in a streptozotocin (STZ)—induced diabetic rat model. Diabetes mellitus (DM) was induced with single intraperitoneal dosage the glucose...
The major goal of this investigation was to prepare a drug delivery polymeric nanoparticles (NPs) from 5-fluorouracil (FU) that could be delivered intravenously and improve the therapeutic index FU. In order achieve this, interfacial deposition method used FU entrapped poly-(lactic-co-glycolic acid) (FU-PLGA-NPs). influence various experimental settings on effectiveness integration into NPs assessed. Our findings show technique organic phase ratio aqueous had greatest impact NPs. results...
Uneven codon usage within genes as well among genomes is a usual phenomenon across organisms. It plays significant role in the translational efficiency and evolution of particular gene. EPB41L3 tumor suppressor protein-coding gene, present study, pattern was envisaged. The full-length sequences gene for human, brown rat, domesticated cattle, Sumatran orangutan available at NCBI were retrieved utilized to analyze CUB patterns selected mammalian species. Compositional properties, dinucleotide...
The current study demonstrates the culture characteristics of adipose tissue and bone marrow-derived mesenchymal stem cells (MSC). evaluates effect ambient temperature, physiological status donor source on sheep (Ovis aries) cells. samples were harvested from full term pregnant female (n = 9) male 10). Adipose was n 9 marrow 10 sheep. (adipose tissue, 2; marrow, 3) transported at cold temperature (<10 °C) failed to yield MSCs while those 14) higher (>20 successfully yielded MSCs. Bone...