A5101630236- Hepatitis C virus research
- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cardiac Structural Anomalies and Repair
- Cancer Research and Treatments
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Hepatitis Viruses Studies and Epidemiology
- Congenital Heart Disease Studies
- Cancer Mechanisms and Therapy
- Urinary Bladder and Prostate Research
- Polymer Surface Interaction Studies
- Bone Metabolism and Diseases
- Growth Hormone and Insulin-like Growth Factors
- Inflammasome and immune disorders
Ningxia Medical University
2020-2025
First Affiliated Hospital of Xi'an Jiaotong University
2020-2024
Southern Medical University
2009-2023
Nanfang Hospital
2009-2023
Affiliated Hospital of Youjiang Medical University for Nationalities
2023
Soochow University
2021-2023
Second Affiliated Hospital of Soochow University
2021-2023
Hubei University
2021-2022
Jinan University
2019
University of Hong Kong
2014
Systematic interrogation of tumor-infiltrating immune cells (TIICs) is key to the prediction clinical outcome and development immunotherapies. However, little known about TIICs hepatocellular carcinoma (HCC) its impact on prognosis patients potential for immunotherapy. We applied CIBERSORT 1090 tumors infer infiltration 22 subsets using gene expression data. Unsupervised clustering analysis by revealed 4 clusters tumors, mainly defined macrophages T cells, with distinct associations...
Background Ventricular diastolic dysfunction in patients with repaired tetralogy of Fallot ( TOF ) may affect atrial mechanics. This study aimed to explore right RA and left LA mechanics their relationship ventricular function. Methods Fifty‐four (36 males), aged 17.8 ± 8.3 years, who had undergone repair at 3.9 3.3 years 40 healthy subjects 16.9 6.3 (P = 0.57) were studied. Right peak positive, negative, total strain, strain rate systole SR s ), early diastole ed contraction ac...
Hepatitis B virus (HBV) infection is a serious global health burden. TRIM26 has been reported to affect hepatitis C replication.To manifest the role of on HBV replication and explore if there are single-nucleotide polymorphisms (SNPs) in associated with response pegylated interferon-alpha (PegIFNα) treatment patients chronic (CHB).We investigated effect mechanism vitro. The association between SNPs PegIFNα was evaluated two independent cohorts including 238 707 HBeAg-positive CHB.Knockdown...
Abstract Aims Osteoprotegerin (OPG) is a recently identified inhibitor of bone resorption. Recent studies indicate that OPG also associated with endothelial dysfunction in Type 2 diabetes. The aim was to investigate the relationship between plasma levels and urinary albumin excretion (UAE) diabetic patients. Methods This study included 154 newly diagnosed patients 46 healthy subjects. Plasma 24‐h UAE were measured. High‐resolution ultrasound used measure flow‐mediated (endothelium‐dependent...
Nootkatone (NKT) exhibits potential pharmacological activities including anti-oxidation and anti-inflammation. Nevertheless, little is known about the roles of NKT in asthmatic airway inflammation. In study, mice were sensitized challenged with ovalbumin (OVA) to establish experimental allergic asthma model. After treatment NKT, lung tissues, peripheral blood, bronchoalveolar lavage fluid (BALF) collected assess inflammatory cytokines, oxidative stress, pathological alternations. The effects...
The special microenvironment of a solid tumor promotes the orientation and colonization facultative anaerobes. Intratumoral bacterial infection disrupts local vascular system to form thrombus, resulting in darkened sites enhanced near-infrared absorption. Based on this, we constructed thermally-induced bacteria (TIB) express programmed cell death protein 1 (PD1) at tissue sites. Under laser irradiation, elevated temperature site not only caused damage cells but also induced expression PD1....
Cancer stemness has been reported to drive hepatocellular carcinoma (HCC) tumorigenesis and treatment resistance. In this study, five HCC cohorts with 1059 patients were collected calculate transcriptional indexes (mRNAsi) by the one-class logistic regression machine learning algorithm. TCGA-LIHC cohort, we found mRNAsi was an independent prognostic factor, 626 mRNAsi-related genes identified Spearman correlation analysis. The risk model (HSRM) trained in cohort significantly discriminated...
Abstract Background and Aim: Hepatitis B virus (HBV) genotyping has been done in most countries, but unfortunately, Pakistan, HBV genotypic distribution is still unclear. The aim of the present study was to determine prevalent genotype subgenotype two populated provinces Pakistan: Punjab Sind. Methods: In total, 236 DNA‐positive samples were selected for by polymerase chain reaction–restriction fragment length polymorphism (RFLP). RFLP results further confirmed with whole genome partial...
Aims: The lack of understanding the biology bone cancer metastasis has limited development effective treatment strategies. aim this study was to characterize tumor cell adhesion molecules and determine active interactions with human marrow endothelial (BME) cells using atomic force microscopy. Materials & methods: A single prostate (PC3) coupled (concanavalin A) microscopy cantilever then placed in contact BME for spectroscopy measurements. Results discussion: Strong adhesive between PC3...
Adenosine triphosphate (ATP) and S-adenosyl-L-methionine (SAM) are important intermediates that widely present in living organisms. Large-scale preparation application of ATP or SAM is limited by expensive raw materials. To lower the production costs for ATP/SAM, this study we used strategies applying engineered multidomain scaffold proteins to synthesize SAM. An artificial protein containing CBM3 domain, IM CL-labeled was assembled form complex 1 catalytic reactions increase production. The...
Purpose: Activation of actin cytoskeleton remodeling is an important stage preceding cancer cell metastasis. Previous genome-wide association studies (GWAS) have identified multiple hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)-associated risk loci. However, limited sample size or strict significance threshold GWAS may cause HBV-related HCC risk-associated genetic loci to be undetected. We aimed investigate the performance SNP rs13025377 in PPP1CB HCC. Patients and Methods:...
TRIM16 has been identified as a tumor suppressor in hepatocellular carcinoma (HCC). This study aimed to investigate whether there are genetic variants influencing HCC risk and/or prognosis and explore the mechanisms. We performed gene-wide single-nucleotide polymorphism (SNP) mining TRIM16. The associations of SNPs with both were assessed through two independent cohorts respectively. Functional experiments underlying A missense variant rs2074890 (G > T, resulting an amino acid substitution...
Small cell lung cancer (SCLC) is a malignant tumor characterized by aggressiveness and dismal prognosis. The specific role of ubiquitin-like PHD RING finger domain (UHRF1), frequently overexpressed cancer-promoting gene in various tumors, poorly understood SCLC. Herein, we explored the potential carcinogenic UHRF1 First, public databases were used to analyze expression SCLC, tissue specimens our center examined confirm results while clinical outcomes collected its relationship with UHRF1....
The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. signal transducer and activator transcription-3 a key mediator the cytokine growth factor signaling pathways drives transcription genes responsible for cancer-associated phenotypes. However, so far, no specific inhibitor has been used in clinical practice. Therefore, targeting cancer therapy highly desired improve outcomes patients with carcinoma.Using small-molecule NT157, effect inhibition on...
We conducted a randomized, open-label, controlled, multicenter study to compare sulbactam/cefoperazone with cefotaxime in terms of efficacy and safety for the treatment hospitalized patients moderate-to-severe bacterial infections. More than two-thirds pathogens recovered from these produced β-lactamase. Two hundred-seven (88.1%) 235 enrolled completed were included evaluations. One hundred-three received (2–4 g/d) administered evenly divided doses every 12 hours by 30-minute intravenous...
To investigate the floating, structural, and controlled-release characteristics of a floating poly(lactic-co-glycolic acid) (PLGA)-based drug delivery system, determine feasibility this system for intravesical instillation.PLGA was dissolved in dimethylacetamide, then mixed with IR780 doxorubicin (DOX) to prepare capable solidification flotation on water at room temperature. Preparations PLGA, PLGA+IR780, PLGA+DOX, PLGA+IR780+DOX were formulated. Their vivo vitro investigated, along their...
The recently updated "Guidelines for the Prevention and Treatment of Chronic Hepatitis B" in China have brought about significant changes. new treatment indications almost mandate implementation a Treat-all strategy chronically HBV-infected population China. While simultaneous negativity hepatitis B surface antigen (HBsAg) virus (HBV) DNA has long been an accepted criterion discontinuation, there controversies over initiation criteria starting with HBsAg HBV positivity. Despite inconsistent...