A5101808354- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Liver Diseases and Immunity
- Advanced Photocatalysis Techniques
- Gut microbiota and health
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Effects of Environmental Stressors on Livestock
- Urinary Bladder and Prostate Research
- Quantum Dots Synthesis And Properties
- Ferroptosis and cancer prognosis
- Testicular diseases and treatments
- Cancer Mechanisms and Therapy
- Geology and Paleoclimatology Research
- Inflammation biomarkers and pathways
- Birth, Development, and Health
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
Ministry of Education of the People's Republic of China
2024-2025
Guangdong Provincial Center for Disease Control and Prevention
2024-2025
European Foundation for the Study of Chronic Liver Failure
2025
Guangdong Ocean University
2020-2025
Children's Hospital of Zhejiang University
2024
Shenzhen Second People's Hospital
2021-2023
Key Laboratory of Guangdong Province
2022-2023
Guangdong Medical College
2023
The gut microbiota is known to be associated with a variety of human metabolic diseases, including dysfunction–associated steatohepatitis (MASH). Fungi are increasingly recognized as important members this community; however, the role fungal symbionts in diseases unknown. We have systematically isolated and characterized fungi, identifying Fusarium foetens an intestinal symbiotic filamentous fungus mice. F. reverses MASH progression mouse models through ceramide synthetase 6 (CerS6)–ceramide...
Oxidative stress is known as one of the main contributors in renal ischemia/reperfusion injury (IRI). Here we hypothesized that Micro-vesicles (MVs) derived from human Wharton Jelly mesenchymal stromal cells (hWJMSCs) could protect kidney against IRI through mitigating oxidative stress. MVs isolated hWJMSCs conditioned medium were injected intravenously rats immediately after unilateral ischemia for 60 min. The animals sacrificed at 24h, 48h and 2 weeks respectively reperfusion. Our results...
Background Neutrophil infiltration and hepatocyte damage are indispensable hallmarks in alcohol-associated hepatitis (AH), yet the underlying crosstalk between neutrophils hepatocytes its role AH pathogenesis remain unclear. Objective We investigate regulatory of leucocyte cell-derived chemotaxin 2 (LECT2) hepatocyte–neutrophil interaction impact on progression. Design used bulk single-cell RNA sequencing to identify hepatocyte-secreted factors targeting neutrophils. analysed serum liver...
Discussion on the role of DEHP in critical period gonadal development pregnant rats (F0), studied evolution F1-F4 generation inter-generational inheritance cryptorchidism and alteration DNA methylation levels testis. Pregnant SD were randomly divided into two groups: normal control group experimental group. From pregnancy 7d to 19d, was sustained gavage 750mg/kg bw/day, observed incidence offspring examined rate female through mating experiments. Continuous recording rat’s weight AGD value,...
Abstract We studied the magnetostratigraphy and sedimentary facies of a 550-m-long drill core from Jiudong Basin in NE Tibetan Plateau. Our aims were to reconstruct late Cenozoic evolution this foreland basin, determine spatiotemporal pattern growth Qilian Shan. The indicates that sequence was deposited during ca. 7–0 Ma. From 6.7–3.0 Ma, sediment accumulation rate increased gradually ∼30 mm/k.y. 120 mm/k.y., which associated with gradual shallow lake/delta front braided rivers. progradation...
Nonalcoholic fatty liver disease (NAFLD) has become a common health care burden worldwide. The high heterogeneity of NAFLD remains elusive and impairs outcomes clinical diagnosis pharmacotherapy. Several classifications have been proposed on the basis clinical, genetic, alcoholic, or serum metabolic analyses. Yet, accurately predicting progression to cirrhosis hepatocellular carcinoma (HCC) in patients challenge. Here, Chinese cohort patients, we classified into three distinct molecular...
Hepatitis B virus (HBV) subgenotypes Ba, C1 (Cs), and C2 (Ce) are the most prevalent HBV variants in China. To investigate virological characteristics of these their clinical implications, we enrolled a cohort 211 patients Guangdong Province China, including 132 with chronic hepatitis infection (CH), 32 liver cirrhosis (LC), 47 hepatocellular carcinoma (HCC) according to examination, function test, ultrasonograph results. Overall, Ba was found 51.2% (108/211), 33.6% (71/211), 15.2% (32/211)...
Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western Eastern types, alcoholism hepatitis B virus (HBV) are, respectively, the main etiologies. To determine whether there are unified diagnostic criteria common treatment programs for different etiologies ACLF, a multicenter prospective cohort with same inclusion disease indicators as those used in European Consortium Acute-on-Chronic Liver Failure Cirrhosis Study is urgently needed Asia, where prevalence...
TiO<sub>2</sub>/In<sub>2</sub>S<sub>3</sub>/CdS ternary porous heterostructure arrays were synthesized and characterised with the aim of enhancing photoelectrochemical visible-light photocatalytic properties.
Gastric cancer (GC) is a malignant disease of the digestive tract and life-threatening worldwide. Ferroptosis, an iron-dependent cell death caused by lipid peroxidation, reported to be highly correlated with gastric tumorigenesis immune activity. However, underlying relationship between ferroptosis tumor microenvironment in GC potential intervention strategies have not been unveiled. In this study, we profiled transcriptome prognosis data ferroptosis-related genes (FRGs) samples TCGA-STAD...
A high aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio is associated with liver injury in disease; however, no data exist regarding its relationship 90-day prognosis patients acute exacerbation of chronic disease. In this study, 3,758 participants (955 advanced fibrosis and 2,803 cirrhosis) from the CATCH-LIFE cohort China were included. The relationships between different AST/ALT ratios risk adverse outcomes (death or transplantation) determined cirrhosis hepatitis B...
The reliability and security of multimedia contents in transmission, communications, storage, usage have attracted special attention. Robust image hashing, also referred to as perceptual is widely applied authentication forensics, retrieval, indexing, digital watermarking. In this work, a novel robust hashing method based on quaternion Zernike moments (QZMs) proposed. QZMs offer sound way jointly deal with the three channels color images without discarding chrominance information; generated...
Abnormal activation of protein kinases and phosphatases is implicated in various tumorigenesis, including hepatocellular carcinoma (HCC). Advanced HCC patients are treated with systemic therapy, tyrosine kinase inhibitors, which extend overall survival. Investigation the underlying mechanism signaling will help to improve efficacy therapy. Combining single-cell RNA sequencing data TCGA RNA-seq data, we profiled kinases, phosphatases, other phosphorylation-related genes (PRGs) this study. We...