A5079142047- Blood Pressure and Hypertension Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Hormonal Regulation and Hypertension
- Coffee research and impacts
- Liver Disease Diagnosis and Treatment
- Sodium Intake and Health
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Alcohol Consumption and Health Effects
- Biomedical Text Mining and Ontologies
- Hepatitis B Virus Studies
- Collagen: Extraction and Characterization
- Veterinary medicine and infectious diseases
- Ferroptosis and cancer prognosis
- Coconut Research and Applications
- Ocean Waves and Remote Sensing
- NF-κB Signaling Pathways
- Underwater Acoustics Research
- Signaling Pathways in Disease
- PI3K/AKT/mTOR signaling in cancer
- HER2/EGFR in Cancer Research
University of Science and Technology of China
2025
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
National University of Singapore
2019-2024
Anhui Medical University
2020-2024
First Affiliated Hospital of Anhui Medical University
2021-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2021-2023
Hypertension Institute
2021-2023
Fourth Affiliated Hospital of Anhui Medical University
2020-2022
Xinjiang Medical University
2022
Background Neutrophil infiltration and hepatocyte damage are indispensable hallmarks in alcohol-associated hepatitis (AH), yet the underlying crosstalk between neutrophils hepatocytes its role AH pathogenesis remain unclear. Objective We investigate regulatory of leucocyte cell-derived chemotaxin 2 (LECT2) hepatocyte–neutrophil interaction impact on progression. Design used bulk single-cell RNA sequencing to identify hepatocyte-secreted factors targeting neutrophils. analysed serum liver...
Objective- Atherosclerotic coronary artery disease is the leading cause of death worldwide, and current treatment options are insufficient. Using systems-level network cluster analyses on a large case-control cohort, we previously identified PCSK3 (proprotein convertase subtilisin/kexin family member 3; FURIN) as several disease-associated pathways. Thus, our objective to determine role FURIN in atherosclerosis. Approach Results- In vitro, inhibitor resulted reduced monocyte migration...
This comprehensive study evaluates the performance of OpenAI's o1-preview large language model across a diverse array complex reasoning tasks, spanning multiple domains, including computer science, mathematics, natural sciences, medicine, linguistics, and social sciences. Through rigorous testing, demonstrated remarkable capabilities, often achieving human-level or superior in areas ranging from coding challenges to scientific processing creative problem-solving. Key findings include: -83.3%...
Caffeine is among the most highly consumed substances worldwide, and it has been associated with decreased cardiovascular risk. Although caffeine shown to inhibit proliferation of vascular smooth muscle cells (VSMCs), mechanism underlying this effect unknown. Here, we demonstrated that VSMC induced macroautophagy/autophagy in an vivo injury model restenosis. Furthermore, studied effects primary human mouse aortic VSMCs immortalized VSMCs. cell proliferation, autophagy flux via inhibition...
Abstract Skin but not vascularized cardiac allografts from B6.H-2bm12 mice are acutely rejected by C57BL/6 recipients in response to the single class II MHC disparity. The underlying mechanisms preventing acute rejection of heart were investigated. induced low levels alloreactive effector T cell priming recipients, and this was accompanied low-level cellular infiltration into allograft that quickly resolved. Recipients with long-term-surviving unable reject skin allografts, suggesting...
Summary The maturation of functional eggs within the ovaries is essential for successful reproduction and organismal functions in mammals. Yet, despite its biological clinical importance, underlying mechanisms regulating folliculogenesis remain enigmatic. Here, we report a novel role surface-anchoring theca cells (TCs) follicle growth through mechanical signalling. Direct measurements reveal that these TCs are highly contractile exert compressive stress to follicular interior, potentially...
The rapid advances in Large Language Models (LLMs) have the potential to transform manufacturing industry, offering new opportunities optimize processes, improve efficiency, and drive innovation. This paper provides a comprehensive exploration of integration LLMs into domain, focusing on their automate enhance various aspects manufacturing, from product design development quality control, supply chain optimization, talent management. Through extensive evaluations across multiple tasks, we...
Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success natural processing. However, the complex traits and heterogeneity of multi-sources genomics data pose significant challenges when adapting these models bioinformatics field. To address challenges, we present GP-GPT, first specialized model for genetic-phenotype knowledge representation relation analysis. Our is fine-tuned two stages on a comprehensive corpus composed over...
Abstract Background Previous studies have suggested Lamin B2 (LMNB2) as an oncogene in lung cancer. However, the role of LMNB2 hepatocellular carcinoma (HCC) remains unclear. Method The expression was compared between HCC samples and non‐tumor multiple datasets. In addition, prognostic value also investigated. Furthermore, cBioPortal utilized to analyze genomic alternation HCC. Besides, co‐expression genes functional enrichment analysis were evaluated using LinkedOmics determine function...
Background: Previous studies have shown that Leukocyte cell-derived chemotaxin2 (LECT2) is associated with the development of HCC. However, there are still no a comprehensive analysis role LECT2 in hepatocellular carcinoma (HCC). Methods: TCGA data sets were used to analyze expression In addition, prognostic value HCC was also investigated. DriverDBv3 Mutation, CNV, and methylation profiles LECT2. And, validated by immunohistochemistry 72 samples. The correlation clinicopathological features...
Chronic hepatitis B (CHB) patients with severe liver fibrosis would be more likely to progress a poorer prognosis. Treatment is considered once the reaches significant (≥S2). Leukocyte cell-derived chemotaxin-2 (LECT2) has been shown contribute progression. No research focused on role of LECT2 in CHB patients. This study enrolled 227 and divided them into training group ( n = 147) validation 80), respectively. The expression serum, protein mRNA human tissues was detected analyze possible...
Background. The Rel/NF-κB transcription factor pathway, regulated by IκB proteins, is considered central to immune responses, although there are surprisingly few in vivo data concerning alloresponses. Methods. We undertook analysis of NF-κB and mRNA intracardiac allograft expression, nuclear translocation, during acute rejection versus CD154 monoclonal antibody (mAb)-induced tolerance induction fully MHC-disparate mice. Results. Intragraft expression all nine genes increased development...
The burden of kidney dysfunction (KD) is rapidly increasing in developing countries due to an ongoing epidemic hypertension and diabetes. We aimed evaluate the prevalence associated factors KD among population with and/or diabetes from primary care setting.This study was part a cross-sectional conducted Northwest China, which investigate epidemiological status other chronic noninfectious diseases. Subjects aged ≥18 years old were included this study. defined as estimated glomerular...
The dynamic systemic inflammation level and stroke-associated infection (SAI) are related to the prognosis of acute ischemic stroke (AIS). We aimed explore whether inflammatory response index (SIRI), immune (SII), their changes possess predictability for SAI long-term prognosis.
It has been shown that in vivo tissues are highly crowded by proteins, nucleic acids, ribonucleoproteins, polysaccharides, etc. The following protocol applies a macromolecular crowding (MMC) technique to mimic this physiological through the addition of neutral polymers (crowders) cell cultures vitro. Previous studies using Ficoll or dextran as crowders demonstrate expression collagen I and fibronectin WI38 WS-1 lines significantly enhanced MMC technique. However, not validated primary...
Abstract Background Uncertainty remains about the association of potassium (K) intake with depression and anxiety status. We explored their relationship using 24‐h urinary K, reflecting K intake, in general population. Methods collected urine performed self‐rating scales (SDS, SAS) cross‐sectionally adults selected by random sampling China. SDS SAS standard score ≥50 defined Participants were divided into three groups (T1, T2, T3) tertile. Odds ratios (OR) 95% confidence intervals...
Large Language Models (LLMs) have demonstrated remarkable success across a wide range of tasks and domains. However, their performance in low-resource language translation, particularly when translating into these languages, remains underexplored. This gap poses significant challenges, as linguistic barriers hinder the cultural preservation development minority communities. To address this issue, paper introduces novel retrieval-based method that enhances translation quality for languages by...
Background: Aneuploidy is crucial yet under-explored in cancer pathogenesis. Specifically, the involvement of brain expressed X-linked gene 4 (BEX4) microtubule formation has been identified as a potential aneuploidy mechanism. Nevertheless, BEX4’s comprehensive impact on incidence across different types remains unexplored. Methods: Patients from The Cancer Genome Atlas (TCGA) were stratified into high-score (training) and low-score (control) groups based score. Mfuzz expression pattern...
Patients with hypertension and glucose metabolism disorder (GMD) are at high risk of developing kidney dysfunction (KD). Therefore, we aimed to develop a nomogram for predicting individuals' 5-year KD in hypertensives GMD.In total, 1961 GMD were consecutively included. Baseline data extracted from medical electronic system, follow-up obtained using annual health check-ups or hospital readmission. was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2. Subjects randomly...
The objective of this paper is to investigate the effects gefitinib as a new stent coating material on proliferation smooth muscle cells and expression phosphorylation EGFR/Akt protein.Rat were cultured in medium with (10 -2 μmol/L-10μmol/L) for 24h-72h.MTT assay was used test inhibition cell proliferation.Western-blot detect EGFR, Akt, phosphorylated EGFR (p-EGFR) Akt (p-Akt).MTT showed that inhibitory effect cells' time concentration dependent manner.Western-blot has no significant change...