A5103113775- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Liver physiology and pathology
- Diabetes Management and Research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Cannabis and Cannabinoid Research
- Immune cells in cancer
- Cancer Genomics and Diagnostics
University of Electronic Science and Technology of China
2014-2025
Sichuan Cancer Hospital
2019-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2014-2023
Jinan University
2023
Macau University of Science and Technology
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
University of Virginia
2008-2009
University of Pennsylvania
2003-2008
National Institutes of Health
2008
National Heart Lung and Blood Institute
2008
Liver fibrosis is a chronic liver disease with the presence of progressive wound healing response caused by injury. Currently, there are no approved therapies for fibrosis. Exosomes derived from human adipose mesenchymal stem cells (hADMSCs-Exo) have displayed prominent therapeutic effect on diseases. However, few studies evaluated hADMSCs-Exo in and cirrhosis, its precise mechanisms action remain unclear. Herein, we investigated anti-fibrotic efficacy vitro vivo, identified important...
Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their pancreatic islet cells. Whether the latter represents a primary defect or is consequence of former unknown. To examine β-cell mass function islets from type patients directly, we isolated pancreata cadaveric donors (n = 14) compared them with normal matched for age, BMI, cold ischemia time. The total recovered was significantly less than that nondiabetic control (256,260 equivalents [2,588 IEq/g...
Abstract Background For chronic hepatitis B virus (HBV) infection patients, increasing evidence has demonstrated the effectiveness of expanding indications and applicable population for antiviral therapy. However, expanded indication therapy hepatocellular carcinoma (HCC) remains to be further explored. Methods 196 HBV-related HCC patients who received radical hepatectomy nucleos(t)ide analogues (NAs) at Sichuan Provincial People’s Hospital were enrolled in this study. recurrence, overall...
To evaluate the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (PA-HAIC) plus programmed death-1 (PD-1) inhibitors versus PA-HAIC alone for hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). This retrospective study included HCC MVI who were treated either or PD-1 between February 2021 2024. The differences in baseline characteristics, disease-free survival (DFS), overall (OS) compared two groups before after propensity...
Objective To restore islet function in patients whose labile diabetes subjected them to frequent dangerous episodes of hypoglycemic unawareness, and determine whether multiple transplants are always required achieve insulin independence. Summary Background Data The recent report by the Edmonton group documenting restoration independence transplantation seven consecutive with type 1 differed from previous worldwide experience only sporadic success. In patients, transplanted mass critical for...
Partial T cell depletion is used in solid organ transplantation as a valuable strategy of peritransplant induction immunosuppression. Using murine cardiac allograft model, we recently demonstrated that this led to lymphopenia-induced (homeostatic) proliferation among the residual nondepleted lymphocytes. Rather than promoting tolerance, cell-depleting Abs actually resulted resistance tolerance by costimulatory blockade. In study show memory cells predominate shortly after subtotal...
Recent improvements in isolated islet transplantation indicate that this therapy may ultimately prove applicable to patients with type I diabetes. An obstacle preventing widespread application of is an insufficient supply cadaveric pancreata. Non-heart-beating donors (NHBDs) are generally not deemed suitable for whole-organ pancreas donation and could provide a significant source pancreata transplantation. Isolated pancreatic islets prepared from 10 NHBDs were compared those procured...
We sought to compare the efficacy, risks, and costs of whole-organ pancreas transplantation (WOP) with isolated islet (IIT) in treatment patients type I diabetes mellitus.A striking improvement has taken place results IIT regard attaining normoglycemia insulin independence diabetic recipients. Theoretically, this minimally invasive therapy should replace WOP because its risks expense be less. To date, however, no systematic comparisons these 2 options have been reported.We conducted a...
Abstract Regulatory T cells preserve tolerance to peripheral self-Ags and may control the response allogeneic tissues promote transplantation tolerance. Although prior studies have demonstrated prolonged allograft survival in presence of regulatory (T-reg), data documenting capacity these immunocompetent transplant models are lacking, mechanism suppression vivo remains unclear. We used a TCR transgenic model rejection characterize activity CD4+CD25+ T-reg. demonstrate that graft Ag-specific...
Abstract Selective interference with the CD45RB isoform by mAb (anti-CD45RB) reliably induces donor-specific tolerance. Although previous studies suggest participation of regulatory T cells, a mechanistic understanding anti-CD45RB-induced tolerance is lacking. We report herein unexpected finding that induced this agent not established in B cell-deficient mice but can be recovered preemptive lymphocyte transfer to hosts. Using cells from genetically modified donors reconstitute recipients, we...
Abstract Hepatocellular carcinoma (LIHC) accounts for 90% of all liver cancers and is a serious health concern worldwide. Long noncoding RNAs (lncRNAs) have been observed to sponge microRNAs (miRNAs) participate in the biological processes LIHC. This study aimed evaluate role ST8SIA6-AS1-miR-142-3p-HMGA1 axis regulating LIHC progression. RT-qPCR western blotting were performed determine levels ST8SIA6-AS1, miR-142-3p, HMGA1 The relationship between was assessed using luciferase assay....
Recent studies in rodent models suggest that liver X receptors (LXRs) may play an important role the maintenance of glucose homeostasis and islet function. To date, however, no have comprehensively examined LXRs human biology. Human islets were isolated from non-diabetic donors incubated presence or absence two synthetic LXR agonists, TO-901317 GW3965, under conditions low high glucose. agonist treatment enhanced both basal stimulated insulin secretion, which corresponded to increase...
Statement of RetractionHsa_circ_0101432 promotes the development hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622We, Editors Publisher journal Cell Cycle, have retracted following article:Haibo Zou, Xiangang Xu, Lanyun Luo, Yu Zhang, Le Yutong Yao, Guangming Xiang, Xiaolun Huang, Guan Wang. Hsa_circ_0101432 miR-622. Cycle. 2019;18(19):2398-2413. doi: 10.1080/15384101.2019.1618120.Since publication, significant concerns been raised about integrity data reported results in...
Liver function, tumor burden, inflammation level, and nutritional status are critical factors influencing onset, progression, metastasis. This study sought to investigate the prognostic significance clinical relevance of biomarkers associated with these develop a novel liver function-tumor burden-inflammation-nutrition (LTIN) score for patients hepatocellular carcinoma (HCC) who received hepatectomy. A retrospective analysis was conducted on 285 HCC undergoing hepatectomy at two medical...
Nonalcoholic fatty liver disease (NAFLD) is the common in liver, which associated with metabolic syndrome and hepatocellular carcinoma. Accumulated evidence establishes that small non-coding microRNAs (miRNAs) contribute to initiation progression of NAFLD. However, molecular repertoire miRNA NAFLD still largely unknown. Here, using an integrative approach spanning bioinformatic analysis functional approaches, we demonstrate miR-124-3p participates development by directly targeting...
Abstract Background There are no validated biomarkers that can predict the clinical benefit of immune checkpoint blockers against programmed cell death protein 1 (PD‐1) treatments in hepatocellular carcinoma (HCC). This study aimed to investigate prognostic value inflammation‐immunity‐nutrition score (IINS) patients with HCC treated anti‐PD‐1 therapy. Methods A consecutive series 101 PD‐1 inhibitors Sichuan Provincial People's Hospital between January 2018 and August 2020 were enrolled...
Targeting of the CD45RB isoform by mAb (anti-CD45RB) effectively induces donor-specific tolerance to allografts. The immunological mechanisms underlying tolerant state remain unclear although some studies have suggested involvement regulatory T cells (T-regs). Although their generative pathway remains undefined, promoting T-regs induced systemic anti-CD45RB treatment been assumed originate in peripheral immune system. We demonstrate herein that separable effects on and central compartments...