A5100460728- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Reproductive Biology and Fertility
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Acute Myeloid Leukemia Research
- Single-cell and spatial transcriptomics
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Chromatin Remodeling and Cancer
- Kruppel-like factors research
- Advanced Nanomaterials in Catalysis
- Macrophage Migration Inhibitory Factor
- Birth, Development, and Health
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Prenatal Substance Exposure Effects
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- Cervical Cancer and HPV Research
- Molecular Biology Techniques and Applications
Xi'an Jiaotong University
2025
Shanghai Jiao Tong University
2023-2025
Beijing Academy of Artificial Intelligence
2025
Shaoxing University
2025
High Magnetic Field Laboratory
2024
University of Science and Technology of China
2024
Hefei Institutes of Physical Science
2024
Tibet Autonomous Region People's Hospital
2024
Nanjing Medical University
2005-2023
Jiangsu Province Hospital
2011-2023
Galectin-1 is implicated in making tumor cells immune privileged, part by regulating the survival of infiltrating T cells. strongly expressed activated pancreatic stellate (PSCs); however, whether this linked to cell escape cancer unknown. was knocked down PSCs isolated from tissues using small interfering RNA (siRNA), or overexpressed recombinant lentiviruses, and were cocultured with CD3(+) , CD4(+) CD8(+) apoptosis detected flow cytometry; IL-2, IL-4, IL-5 INF-γ production levels...
It is well known that high-risk human papilloma virus (HR-HPV) infection strongly associated with cervical cancer and E7 was identified as one of the key initiators in HPV-mediated carcinogenesis. Here we show lactate dehydrogenase A (LDHA) preferably locates nucleus HPV16-positive tumors due to E7-induced intracellular reactive oxygen species (ROS) accumulation. Surprisingly, nuclear LDHA gains a non-canonical enzyme activity produce α-hydroxybutyrate triggers DOT1L (disruptor telomeric...
DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding its role in intestinal limited.We use whole genome bisulfite sequencing, find that differentiation mouse colonic stem cells epithelium not associated with major changes methylation. However, we detect extensive dynamic their progeny during the suckling period, suggesting postnatal this cell population. We increases at 3' CpG islands (CGIs) correlate...
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability thermodynamic solubility issues associated with previous lead compound 1. The incorporated an sp3 hybridized carbon atom at the 7-position lactam moiety present in 1 as a replacement for dimethylisoxazole group. This transformation enabled optimization physicochemical properties potency compared Analysis relationships between calculated log...
Background and Aim: DOT1L regulates various genes involved in cancer onset progression by catalyzing H3K79 methylation, but how activity itself is regulated unclear. Here, we aimed to identify specific post-translational modifications that might regulate thus impact on colorectal (CRC) progression. Methods: We conducted affinity purification mass spectrometry explore modifications. then established transwell migration invasion assays specifically investigate the role of DOT1L(K358)...
Single-cell or low-input multi-omics techniques have revolutionized the study of pre-implantation embryo development. However, single-cell proteomic research in this field is relatively underdeveloped because higher threshold starting material for mammalian samples and lack hypersensitive proteome technology. In study, a comprehensive solution ultrasensitive technology (CS-UPT) was developed mouse oocyte/embryo samples. The deep coverage high-throughput routes significantly reduced were...
Chronic pain alters the configuration of brain functional networks. Primary dysmenorrhea (PDM) is a form chronic visceral pain, which has been identified spatial alterations in networks using static connectivity analysis methods. However, dynamics during pain-free periovulation phase remain unclear. Using co-activation pattern (CAP) method, we investigated dynamic network characteristics and their relationship with pain-related emotions sample 59 women PDM 57 demographically matched healthy...
Abstract Nowadays, the knowledge in DNA methylation-mediated gene regulation has shed light on understanding of virus-host interplay context genome alteration. It also been shown that HIV is able to change methylation pattern by methyltransferases and such changes can be correlated with progression AIDS. In this study, we have investigated relationship between genome-wide infection using methylated immunoprecipitation - microarray method. A pair monozygotic twins was recruited: one infected...
The polycomb repressor B lymphoma Mo-MLV insertion region 1 (BMI1) is a core composition of repressive complex (PRC1) and contributes to diverse fundamental cellular processes including cell senescence, apoptosis proliferation.To investigate the role mechanism BMI1 in maintaining normal female reproductive function, we compared differences phenotypes between Bmi1-deficient wild-type mice.The mice were then supplemented with N-acetylcysteine their drinking water explore whether antioxidant...
Loss of heterozygosity (LOH) is one the most common genetic abnormalities in cancer. To define role LOH and chromosomal at various stages mouse mammary cancer progression, we analyzed allelotypes karyotypes primary tumors induced CD2F1 mice by two basic protocols, classical multiple-dose 7, 12-dimethylbenz[a]anthracene (DMBA) protocol a novel combined medroxyprogesterone acetate (MPA) DMBA. The advantage latter that its latency for tumor development much shorter incidence higher than those...
Abstract Histone deacetylases (HDACs) have been implicated in numerous biological events. However, to date, the role of HDAC6 early embryos remains unknown. In current study, Tubastatin A (TubA), a potent inhibitor, was used block activity mouse embryos. We found that TubA exposure significantly reduced blastocyst formation Confocal microscopy revealed markedly increased chromosomal congression failure treated with inhibitor. Moreover, inhibition resulted overproduction reactive oxygen...
PF06821497 has been identified as an orally available small-molecule enhancer of zeste homolog 2 inhibitor. The objectives the present study were to characterize pharmacokinetic-pharmacodynamic-disease relationships in xenograft mouse models with diffuse large B-cell lymphoma (Karpas422). An indirect-response model reasonably fit dose-dependent pharmacodynamic responses [histone H3 on lysine 27 (H3K27) me3 inhibition] unbound <i>EC</i><sub><i>50</i></sub> 76 nM, whereas a signal-transduction...