A5008498701- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Prenatal Screening and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Pluripotent Stem Cells Research
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Colorectal and Anal Carcinomas
- Virus-based gene therapy research
- Reproductive System and Pregnancy
- Genetic Syndromes and Imprinting
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Cell death mechanisms and regulation
- Sexual Differentiation and Disorders
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
First Affiliated Hospital of Wenzhou Medical University
2015-2025
Wenzhou Medical University
2015-2025
Hengyang Normal University
2025
Materials Science & Engineering
2025
Zhejiang A & F University
2025
Capital Medical University
2021-2024
Beijing Ditan Hospital
2021-2024
National Institute for Communicable Disease Control and Prevention
2023-2024
Guangxi Medical University
2024
Sir Run Run Shaw Hospital
2011-2024
Acetamiprid (ACE) and imidacloprid (IMI) are two major members in the family of neonicotinoid pesticides, which synthesized with a higher selectivity to insects. The present study determined compared vitro effects ACE, IMI nicotine on mammalian reproduction by using an integrated testing strategy for reproductive toxicology, covered sperm quality, penetration into oocytes preimplantation embryonic development. Direct chemical exposure (500 µM or 5 mM) spermatozoa during capacitation was...
To investigate effect of sperm DNA fragmentation (SDF) on clinical outcomes assisted reproductive technology in women with normal ovarian reserve (NOR) versus reduced (ROR).Retrospective study.University-affiliated tertiary teaching hospital.A total 2,865 consecutive couples undergoing their first vitro fertilization (IVF) or intracytoplasmic injection (ICSI) cycle.SDF assessed using chromatin dispersion samples 1-2 months before treatment.SDF, IVF, and ICSI outcomes.The grouping criteria...
The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence PCOS and determine influence reproductive hormones on uric acid concentration.This retrospective cross-sectional study was performed at a large medicine center. Between March 2007 October 2016, total 1,183 women with 10,772 without were included. diagnosed according Rotterdam criteria. Anthropometric parameters, blood pressure, acid, hormones, glucose lipids measured...
With the rapid development of artificial intelligence and industrial Internet Things (IIoT) technologies, intelligent predictive maintenance (IPdM) has received considerable attention from researchers practitioners. To efficiently predict impending failures mitigate unexpected downtime, while satisfying instant demands facilities is very important for improving production efficiency. In this article, a self-attention based "Perception Prediction" framework, called DeepHealth, proposed IPdM....
ObjectiveTo investigate the antiapoptosis effect of sphingosine-1-phosphate (S1P) on human fetal ovarian tissue treated by cyclophosphamide (CTX).DesignExperimental animal study.SettingUniversity center for reproductive medicine and IVF unit.Animal(s)Female immunodeficient BALB/c nude mice, 6 to 8 weeks old.Intervention(s)Human slowly cryopreserved then subcutaneously transplanted in mice.Main Outcome Measure(s)Follicle survival assessed qualitatively quantitatively using H&E staining,...
The accumulated data suggest that inflammation can increase the level of reactive oxygen species (ROS), which contribute to impaired sperm function and male infertility. Therefore, we propose inflammation-mediated production ROS in female reproductive tracts hinder fertilisation. To test this hypothesis, phorbol myristate acetate (PMA) with polymorphonuclear leucocytes (PMNs) was applied generate endogenous ROS. We evaluated time-dependent effects on human motility, viability mitochondrial...
Purpose5-Fluorouracil (5-Fu) is used as a conventional chemotherapy drug in for patients with advanced colorectal cancer, but many still suffer from treatment failure due to 5-Fu resistance. Emerging observations revealed the important role of chemokine (C-X-C motif) ligand 13 (CXCL-13) tumor microenvironment and its relationship prognosis cancer. This study designed reveal CXCL-13 causing cancer resistance 5-Fu.Materials MethodsCXCL-13 levels patient's serum or cell culture supernatants...
5-Fluorouracil (5-Fu) is the first-line chemotherapeutic option for colorectal cancer. However, its efficacy inhibited by drug resistance. Cytokines play an important role in tumor resistance, even though their mechanisms are largely unknown. Using a cytokine array, we established that tissue inhibitor metalloproteinase 2 (TIMP-2) highly expressed 5-Fu resistant cancer patients. Analysis of samples from 84 patients showed elevated TIMP-2 expression levels were correlated with poor prognostic...
Abstract Background A growing number of investigations have suggested a close link between cancer stem cells (CSCs), epithelial-to-mesenchymal transition (EMT), and the tumor microenvironment (TME). However, relationships these physiological processes in bladder urothelial carcinoma (BLCA) remain unclear. Methods We first explored biomarkers stemness (TS) by single-cell sequencing analysis. Then, subtypes were identified using clustering analysis based on TS biomarkers. The score was...
The synthesis of perfluoroalkylated fullerenes (PFAFs) holds significant importance due to their enhanced molecular stability, increased lipophilicity, and high electron affinity. Herein, we report a copper-catalyzed multicomponent reaction conducted under aerobic conditions, which enables the production highly soluble PFAFs with half-wave reduction potentials similar those C60. Furthermore, challenges posed by C-F coupling in carbon signal assignment were addressed through...
<sec> <title>BACKGROUND</title> Seasonal influenza remains a major global public health concern, causing substantial morbidity and mortality. Traditional early warning models rely on binary (0/1) classification methods, issuing alerts only when predefined thresholds are crossed. However, these lack flexibility, often leading to false alarms or missed warnings, fail provide granular risk assessments for decision-making. To address limitations, we propose probability-based system using machine...
Environmentally friendly hydrochar demonstrates excellent performance in the treatment of cationic pollutants, yet its capability to address anions is limited. Cationic imidazolium ionic liquids carry a positive charge, and modification surface can increase thereby improving ability remove anions. Herein, bis-imidazolium-based poly(ionic liquid)-functionalized (BIPIL-HC) was prepared using derived from hydrothermal carbonization bamboo powder N,N'-methylene-bis(1-(3-vinylimidazolium))...
Pityrosporum orbiculare and Candida albicans extracts were separated bySDS‐PAGE, IgE binding was detected by immunoblotting with 21 patient sera that RAST positive to both yeasts. Cross‐wise inhibition performed of a serum pool containing antibodies The mixed serial dilutions P. or C. extracts, incubated strips allergen. quantified densitometric scanning percent calculated as well the respective ratios between required extract concentration for 50% in heterologous compared homologous each...
The present study was undertaken to determine the reproductive hazards of Di-(2-ethylhexyl)-phthalate (DEHP) on mouse spermatozoa and embryos in vitro genomic changes vivo. Direct low-level DEHP exposure (1 μg/ml) investigated by fertilization (IVF) process, culture preimplanted DEHP-supplemented medium embryo transfer achieve full term development. Big Blue® transgenic model employed evaluate mutagenesis testicular genome with vivo concentration (500 mg/kg/day). Generally, DEHP-treated...
During the last decades, many studies have shown possible influence of sperm DNA fragmentation on assisted reproductive technique outcomes. However, little is known about impact clinical outcome frozen-thawed embryo transfer (FET) from cycles conventional in vitro fertilization (IVF) and intra-cytoplasmic injection (ICSI). In present study, relationship between (SDF) FET outcomes IVF ICSI was analyzed. A total 1082 with cleavage stage embryos (C-FET) (855 227 ICSI) 653 blastocyst (B-FET)...