A5115614285- Aluminum Alloys Composites Properties
- SARS-CoV-2 and COVID-19 Research
- Rock Mechanics and Modeling
- Aluminum Alloy Microstructure Properties
- HIV Research and Treatment
- Advancements in Battery Materials
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- RNA Research and Splicing
- Microwave Engineering and Waveguides
- Geotechnical and Geomechanical Engineering
- Particle physics theoretical and experimental studies
- Microstructure and mechanical properties
- Birth, Development, and Health
- Body Composition Measurement Techniques
- Cancer-related molecular mechanisms research
- Obesity, Physical Activity, Diet
- Pneumonia and Respiratory Infections
- Nutrition and Health in Aging
- Nanomaterials for catalytic reactions
- Plant Gene Expression Analysis
- Pituitary Gland Disorders and Treatments
- Radio Frequency Integrated Circuit Design
- Adenosine and Purinergic Signaling
- COVID-19 Clinical Research Studies
Southwest Medical University
2025
Capital Medical University
2016-2025
National Institute for Communicable Disease Control and Prevention
1970-2025
Beijing Ditan Hospital
1970-2025
Qingdao University
2024-2025
Chinese Academy of Sciences
2011-2025
Nanjing Medical University
2024-2025
West China Hospital of Sichuan University
2025
Howard Hughes Medical Institute
2024-2025
Boston Children's Hospital
2024-2025
Background Since the first HIV/AIDS case appeared in 1980s, has been focus of international attention. As a major public health problem, there are epidemiological uncertainties about future HIV/AIDS. It is important to monitor global statistics prevalence, deaths, disability adjusted life years (DALYs), and risk factors for adequate prevention control. Methods The Global Burden Disease Study 2019 database was used analyze burden 1990–2019. By extracting global, regional, national data on...
Catechins, a class of polyphenolic compounds found in tea, have attracted significant attention due to their numerous health benefits, particularly for the treatment and protection hypertension. However, potential targets mechanisms action catechins combating hypertension remain unclear. This study systematically investigates anti-hypertensive tea using network pharmacology, molecular docking, dynamics simulation techniques. The results indicate that 23 eight catechin components were...
Metal halide perovskites have garnered significant attention in the scientific community for their promising applications optoelectronic devices. The application of pressure engineering, a viable technique, has played crucial role substantially improving characteristics perovskites. Despite notable progress understanding ground-state structural changes under high pressure, comprehensive exploration excited-state dynamics influencing luminescence remains incomplete. This Perspective delves...
Abstract The innate immune sensor PKR for double-stranded RNA (dsRNA) is critical antiviral defense, but its aberrant activation by cellular dsRNA linked to various diseases. dsRNA-binding protein PACT plays a yet controversial role in this pathway. We show that directly suppresses endogenous ligands, such as inverted-repeat Alu RNAs, which robustly activate the absence of PACT. Instead competing binding, prevents from scanning along dsRNA—a necessary step molecules encounter and...
Sarcopenia is an important indicator of ill health and linked to increased mortality a reduced quality life. Age-associated muscle mass indices provide critical tool help understand the development sarcopenia. This study aimed develop sex- age-specific percentiles for in Chinese population compare those with from other ethnicities using National Health Nutrition Examination Survey (NHANES) data.
Abstract Vegetation restoration has an important effect on soil carbon (C) pool dynamics. Highly stable iron (Fe)‐associated C is component of the and it plays a crucial role in cycle. However, knowledge gap remains regarding existence Fe‐associated variation during vegetation restoration. Herein, 0–60 cm samples cropland, grassland, shrubland forestland from three types (loam, loess sandy soils) were collected to explore response The results showed that proportion study area ranged 2.2%...
During tumor expansion, breast cancer (BC) cells often experience reactive oxygen species accumulation and mitochondrial damage because of glucose shortage. However, the mechanism by which BC deal with glucose-shortage-induced oxidative stress remains unclear. Here, we showed that MANF (mesencephalic astrocyte derived neurotrophic factor)-mediated mitophagy facilitates cell survival under glucose-starvation conditions. MANF-mediated also promotes fatty acid oxidation in glucose-starved...
Mycoplasma pneumoniae (MP) is a leading cause of community-acquired pneumonia (CAP), accounting for 10–40% cases in children. In China, the high prevalence macrolide-resistant MP (MRMP) and recurrent epidemics place significant burden on healthcare system. Leveraging data from over 1.6 million cases, this study provides comprehensive analysis epidemiological characteristics across China. Seasonal patterns revealed three distinct transmission zones Transmission Zone 1 exhibited two annual...
To identify predictors of clinically important abnormal findings in computed tomography (CT) images the head among emergency department (ED) patients without a history trauma.Approval was obtained from institutional research ethics board, and informed consent not required. This study retrospective review consecutive unenhanced CT examinations aged 18 years or older who did have trauma known intracranial pathologic processes ED January 2004 through June 2006. Multivariable logistic regression...
Inspired by recent progress in developing gradient materials with excellent performances, here we report a systematic finite-element based investigation to show how the strength and tensile ductility of crystalline metals depend on their microstructure characteristics. We reveal that yielding polycrystalline grain size can be significantly enhanced at no reduction ductility. By employing representative 3D voronoi sample, demonstrate redistribution stress deformation structure - stronger...
The 3rd generation Al–Li alloy is a good candidate for large panel fabrication adopting creep age forming (CAF) because of its balanced synergy high strength, toughness, corrosion resistance and light weight. In this study, the creep-ageing behaviour 2xxx series in T8 state has been experimentally investigated under different stresses ranging from 300 to 430 MPa at 143 °C up 20 h. corresponding evolution precipitate size, distribution dislocation density during CAF analysed using...
Abstract Background A growing number of investigations have suggested a close link between cancer stem cells (CSCs), epithelial-to-mesenchymal transition (EMT), and the tumor microenvironment (TME). However, relationships these physiological processes in bladder urothelial carcinoma (BLCA) remain unclear. Methods We first explored biomarkers stemness (TS) by single-cell sequencing analysis. Then, subtypes were identified using clustering analysis based on TS biomarkers. The score was...
The basic helix-loop-helix (bHLH) transcription factors play crucial roles in various processes, such as plant development, secondary metabolism, and response to biotic/abiotic stresses.
Solar-driven carbon dioxide (CO
To explore the clinical characteristics and analyze pathogens of bacterial meningitis in children.Bacterial cases occurring from January 2010 through December 2014 at Beijing Children's Hospital were reviewed retrospectively. The records all patients, including data on features laboratory information, obtained analyzed.In total, 507 pediatric patients seen over a 5-year period analyzed; 220 these etiologically confirmed. These classified into four age groups: 29 days to 1 year (n=373,...