A5005128294- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Regulation of Appetite and Obesity
- Human Health and Disease
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Child Nutrition and Water Access
- Public Health and Nutrition
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Cardiovascular Health and Disease Prevention
- Health and Lifestyle Studies
State Key Laboratory of Food Science and Technology
2024-2025
Jiangnan University
2024-2025
Ministry of Education of the People's Republic of China
2022-2025
Capital Medical University
2018-2025
Beijing Children’s Hospital
2018-2025
Capital Institute of Pediatrics
2015-2024
Imperial College London
2024
UK Research and Innovation
2024
Medical Research Council
2024
Innovate UK
2024
Reduced birthweight is associated with increased risk for the insulin resistance syndrome. Part of this hypothesized to originate from undernutrition in utero. The prevalence syndrome increases countries that undergo transition chronic malnutrition adequate nutrition, when postnatal nutrition improves more rapidly than prenatal nutrition.To determine whether components are reduced fetal growth and maternal undernutrition.A nonconcurrent, prospective study men women whose mothers' heights...
The study aimed to assess the prevalence of obesity and related behavioral risk factors among children in Beijing.Data were collected as part a 2004 comprehensive on metabolic syndrome 21 198 children, aged 2-18 years old Beijing. Four local international references for classification childhood overweight compared.The combined old, was 18.7%, 21.4%, 20.1% based International Obesity Task Force (IOTF) reference, new World Health Organization (WHO) growth standard, US 2000 Center Disease...
Abstract Objective The aim of this study is to assess the association between degree insulin resistance and different components metabolic syndrome among Chinese children adolescents. Moreover, determine cut-off values for homeostasis model assessment (HOMA-IR) at MS risk. Methods 3203 aged 6 18 years were recruited. Anthropometric biochemical parameters measured. Metabolic (MS) was identified by a modified Adult Treatment Panel III (ATP III) definition. HOMA-IR index calculated normal...
Abstract Few prospective studies have reported the cumulative incidence of venous thromboembolism (VTE) in intensive care unit (ICU), especially for patients receiving guideline-recommended VTE prophylaxis. We aimed to design a observational study investigate and risk factors ICU-acquired those populations. prospectively studied 281 consecutively included ICU at single center. All provided informed consent. Patients received ultrasound evaluation were followed before discharge or within 28...
Background The differential impact of serum lipids and their targets for lipid modification on cardiometabolic disease risk is debated. This study used Mendelian randomization to investigate the causal relationships underlying mechanisms. Methods Genetic variants related profiles were sourced from Global Lipids Genetics Consortium. Summary data 10 diseases compiled both discovery replication sets. Expression quantitative trait loci relevant tissues employed evaluate significant...
BACKGROUND: The mediating role of inflammatory biomarkers in the causal relationship between body composition and hypertension remains unclear requires further investigation. METHODS: This study used a combination retrospective observational analysis Mendelian randomization approaches. Observational data were derived from 4717 Chinese children adolescents aged 6 to 18 years who underwent dual-energy X-ray absorptiometry assess composition. analyses utilized summary statistics large-scale...
Abstract Background Previous genome-wide association studies for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated ( FTO ) gene region is with body index (BMI) European children adults. A significant of same risk allele has been described Asian adult populations, but results are conflicting. In addition, no replication conducted adolescents ancestry. Methods population-based survey was carried out among 3503 (6-18...
OBJECTIVE Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and obesity. The associations of those SNPs among other ethnicities are not fully described, especially children. Among previously SNPs, we selected six (rs7138803, rs1805081, rs6499640, rs17782313, rs6265, rs10938397, or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF,...
Data about metabolic syndrome (MetS) in children is limited China. We aimed to assess the prevalence of MetS related components, and their association with obesity. were collected as part a representative study on among 19593 children, aged 6-18 years old Beijing. General obesity was assessed by body mass index (BMI) central waist circumference. Finger capillary blood tests used triglyceride (TG), total cholesterol (TC) impaired fasting glucose (IFG). Vein samples from subsample 3814 10-18...
Previous studies showed that prevalence of abdominal obesity among US children and adolescents increased significantly between 1988-1994 2003-2004. However, little is known about recent time trends in since 2003-2004.This study was to provide updated national estimates childhood examine the from 2003 2012.Data were National Health Nutrition Examination Survey (NHANES) conducted during 5 periods (2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012). A total 16,601 aged 2 18 years included....
Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, we examined mechanism underlying effect PCB-153 on glucose and lipid metabolism in vivo vitro. We found induced per se worsened high fat diet (HFD)-resulted increase blood level insulin intolerance. addition, HFD-resulted triglyceride content adipose mass. Moreover, concentration-dependently inhibited insulin-dependent uptake accumulation...
Available data related to the metabolically healthy obesity (MHO) phenotype are mainly derived from studies in adults because during childhood very limited date.The objective of study was determine prevalence MHO Chinese children and investigate environmental genetic factors impacting on status.This a cross-sectional study.A total 1213 with body mass index at 95th percentile or greater aged 6–18 years were included this study. Participants classified as unhealthy based insulin resistance...
To determine whether the professional Omron HBP-1300 blood pressure (BP) monitor meets American Association for Advancement of Medical Instrumentation (AAMI) accuracy standards in Chinese children and adults. According to AAMI protocol, simultaneous auscultatory measurements by two observers using a mercury manometer were obtained participants HBP-1300. Triple after minimum 5-min rest with 1-min interval between adjacent measurements. A total 85 submitted 255 doctor-measured BP successful...
Abstract Background Skeletal muscle as an essential body composition component plays important role in maintenance of normal growth and development well systemic glucose metabolism children. No nationwide reference data for skeletal mass Chinese youths are available China. We aimed to establish the sex‐specific age‐specific percentile values children adolescents. Methods This study consisted 10 818 adolescents aged 3–17 years urban area during 2013–15. Dual‐energy X‐ray absorptiometry scan...
Hyperuricaemia can lead to gout and is associated with an increased risk of cardiometabolic disease. We aimed investigate the prevalence hyperuricaemia its related factors in Chinese children adolescents. pooled data from 11 population-based studies comprising 54,580 participants aged 3-19 years. The sex- age-standardized was estimated overall by sex, age, weight status, geographic region survey year. Serum uric acid (SUA) gradually 3 years no significant sex difference, then dramatically...
Sarcopenia is an important indicator of ill health and linked to increased mortality a reduced quality life. Age-associated muscle mass indices provide critical tool help understand the development sarcopenia. This study aimed develop sex- age-specific percentiles for in Chinese population compare those with from other ethnicities using National Health Nutrition Examination Survey (NHANES) data.
This paper shows that: (1) the mean residual life (MRL) of a component has an upside-down bathtub-shape if failure-rate function, but converse does not hold; and (2) there is optimal burn-in policy to maximize MRL when underlying lifetime distribution failure rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>