A5090473298- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Hepatitis C virus research
- Genetics, Aging, and Longevity in Model Organisms
- Hepatitis B Virus Studies
- Diet, Metabolism, and Disease
- Bioinformatics and Genomic Networks
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Nutrition, Genetics, and Disease
- Lipid metabolism and disorders
- Circadian rhythm and melatonin
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Tuberculosis Research and Epidemiology
- Pancreatic function and diabetes
- Neurological Disease Mechanisms and Treatments
Capital Medical University
2016-2025
Beijing Tongren Hospital
2025
Beijing Institute of Neurosurgery
2025
Ministry of Education of the People's Republic of China
2024-2025
Ocean University of China
2025
Beijing Anzhen Hospital
2025
Fudan University Shanghai Cancer Center
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Harbin Medical University
2021-2024
Southeast University
2024
Soil moisture products acquired from passive satellite missions have been widely applied in environmental processes. A primary challenge for the use of soil sensors is their reliability. It crucial to evaluate reliability those before they can be routinely used at a global scale. In this paper, we evaluated Moisture Active/Passive (SMAP) and Advanced Microwave Scanning Radiometer (AMSR2) radiometer against situ measurements collected American networks with four statistics, including mean...
Abstract Background It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights role of in Alzheimer’s disease (AD). However, it remains largely unclear about AD. Methods Here, we conducted comprehensive analyses including genetic association study, expression analysis, eQTLs and colocalization analysis. In stage 1, analysis using large-scale genome-wide study (GWAS) datasets from...
: Neutrophil elastase has been identified as a potential therapeutic target for acute lung injury or respiratory distress syndrome, and Sivelestat is selective, reversible competitive neutrophil inhibitor. This study was designed to investigate the safety, tolerability, pharmacokinetics inhibitory effects of in healthy Chinese subjects. A randomized, double-blind, placebo-controlled single- multiple-dose escalation clinical trial carried out. Briefly, volunteers twelve cohorts with 8 per...
Aging refers to the physical and functional decline of tissues over time that often leads age-related degenerative diseases. Accumulating evidence implicates senescence neural stem cells (NSCs) is paramount importance aging central system (CNS). However, exploration underlying molecular mechanisms has been hindered by lack proper models allow mechanistic examination within a reasonable window. In present study, we have utilized hydroxyurea (HU) treatment protocol effectively induced...
Available data related to the metabolically healthy obesity (MHO) phenotype are mainly derived from studies in adults because during childhood very limited date.The objective of study was determine prevalence MHO Chinese children and investigate environmental genetic factors impacting on status.This a cross-sectional study.A total 1213 with body mass index at 95th percentile or greater aged 6–18 years were included this study. Participants classified as unhealthy based insulin resistance...
Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer's disease (AD) using large-scale AD genome-wide (GWAS), GWAS by proxy (GWAX), and meta-analyses GWAX (GWAS+GWAX) datasets. However, it currently remains unclear about consistency MR estimates across these GWAS, GWAX, GWAS+GWAX Here, we first selected 162 independent educational attainment genetic variants as potential instrumental variables (N = 405,072). We then one...
Purpose To evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, oxidative stress with impaired glucose tolerance (IGT) insulin resistance (IR). Methods 120 individuals IGT IR were randomly divided into four groups treated (1) chromium, (2) magnesium, (3) or (4) placebo. Metabolic inflammatory indicators measured at baseline after 3 months intervention. Results Comparison among showed that fasting plasma (FPG), 2 h post (2hPPG), (FINS) homeostatic...
Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating association between childhood RBP4 and syndrome (MS) in adulthood are lacking. We investigated whether during predict cardiometabolic risk at 10-year follow-up. The relationships levels, established adipokines (leptin adiponectin) components MS were examined 3445 school-aged children recruited 2004 for Beijing Child Adolescent Metabolic Syndrome...
Leptin and adiponectin have opposite effects on subclinical inflammation insulin resistance, both involved in the development of metabolic syndrome (MS). We aimed to investigate whether leptin/adiponectin ratio (L/A), as a marker these two adipokines imbalance, may improve diagnosis MS children adolescents, determined its cut-off value MS.A total 3,428 subjects aged 6-18 years were selected from Beijing Child Adolescent Metabolic Syndrome study. Adipokine leptin measured using enzyme-linked...
Short sleep is an obesity risk factor, however, little known about its interplay with genetic predisposition and pathways involved in pathogenesis, especially the longitudinal setting. We aimed to investigate a possible sleep-gene interaction for childhood risk, whether longitudinally contributes at 10-year follow-up further test if there any mediation through leptin pathway. A total of 3211 children from China (6–18 years) baseline 848 participants Beijing Child Adolescent Metabolic...
To assess the associations between sleep duration and cardiometabolic risk factors in Chinese school-aged children to explore possible mediating role of adipokines. Sleep was collected 3166 from Beijing Child Adolescent Metabolic Syndrome study. Glucose homeostasis other were assessed. Serum adipokines including leptin, total high-molecular-weight (HMW) adiponectin, resistin, fibroblast growth factor 21 (FGF21), retinol binding protein 4 (RBP4) determined. Among 6- 12-year-old children,...
Background The role of adipokine dysregulation in determining the metabolic fate obesity is not well studied. We aimed to examine whether matricellular protein osteonectin and profiles certain adipokines could differentiate metabolically healthy obese ( MHO ) versus unhealthy phenotypes childhood. Methods Results This study included 1137 children 982 normal‐weight NWH controls recruited from BCAMS (Beijing Child Adolescent Metabolic Syndrome) study. was defined by absence insulin resistance...
To explore the trend of hearing changes in infants with
Background: Despite antihypertensive treatment, some high-risk hypertensive patients still experience major adverse cardiovascular events (MACEs). Current risk stratification tools may underestimate the presence of metabolites in hypertension and thereby MACEs. Objectives: We aimed to explore potential value gut microbiota-derived metabolite phenylacetylglutamine (PAGln) hypertension. Methods: measured plasma PAGln levels using liquid chromatography tandem mass spectrometry 1543 patients,...
This article aims to identify research hotspots and trends in on SLC26A4 gene-related hearing loss through bibliometric visual analyses, providing a reference direction for future research. Publications gene from 1994 2023 were retrieved the Web of Science Core Collection database. Bibliometric analysis was conducted using Bibliometrix 4.0.0 R package, CiteSpace 6.2.R6 software, VOSviewer 1.6.20. The encompassed journals, authors, keywords, institutions, countries, references. Based results,...
PROTACs that degrade target proteins to treat diseases represent a highly promising strategy in drug design. However, the degradation of nondisease tissues may lead systemic toxicity. Herein, capitalizing on characteristic overexpression PSMA prostate cancer, we devised PSMA-guided PROTACs-specific targeting cancer. By conjugation AR degraders and BET separately with ligands via cleavable linkers, two classes were obtained. In vitro experiments demonstrated selectively degraded...
PROTAC and molecular glue present a novel therapeutic approach to tackle diseases propelled by the aberrant expression of disease-causing proteins. In this study, we identified number AR/AR-V7 GSPT1 degraders that possess both characteristics. The exploration SAR led discovery BWA-6047 as potent degrader. exhibited protein degradation in 22Rv1 cells (AR: DC50 = 3.7 nM, Dmax 90%; AR-V7: 3.0 93%; GSPT1: 1.2 94%). Mechanism experiments indicate functions degrade target Oral administration at 20...
The utility of any non-rodent model system for chemical toxicity screening depends on the level correlation between its responses and toxic reactions in rodents. Toxicity assays nematode Caenorhabditis elegans (C. elegans) can be fast inexpensive; however few studies have been performed comparing with data acute rodent toxicity. We assayed 21 types chemicals different categories using C. elegans. nematodes were exposed to concentrations 96-well plate 24 h. lethality rate was observed at 2,...