A5102847982- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Management of metastatic bone disease
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- HER2/EGFR in Cancer Research
- Lymphatic System and Diseases
- Cancer Mechanisms and Therapy
- Gestational Trophoblastic Disease Studies
- Toxin Mechanisms and Immunotoxins
- Multiple and Secondary Primary Cancers
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer Risks and Factors
- Selenium in Biological Systems
- Ferroptosis and cancer prognosis
- Cancer survivorship and care
- Genetic factors in colorectal cancer
- Galectins and Cancer Biology
Zhejiang Cancer Hospital
2015-2025
University of Chinese Academy of Sciences
2020-2025
Cancer Hospital of Chinese Academy of Medical Sciences
2020-2025
Chinese Academy of Sciences
2024-2025
Hangzhou Cancer Hospital
2025
Zhejiang Hospital
2020
106 Background: Current first-line standard therapy (SOC) for R/M CC is platinum-based chemotherapy +/- bevacizumab (bev). AK104 monotherapy has shown promising efficacy and tolerable toxicity in pretreated (NCT04380805). In this study, we report the safety of combined with SOC treatment (NCT04868708). Methods: The multicenter, open-label, phase II study enrolled pts without previous systemic therapy. Eligible pathological types were squamous cell carcinoma, adenocarcinoma, or adenosquamous...
<title>Abstract</title> Cervical intraepithelial neoplasia (CIN), as precancerous lesions of cervical carcinoma, are closely linked to the prevalence and progression cancer. We conducted a prospective study 81 participants with CIN 1/2/3 HR-HPV infection assessed safety efficacy 1% Capilliposide B C vaginal gel (CVG) for them. Group 1 received CVG intravaginally every other day 4 weeks preliminary evaluation. After confirming no significant side effects, 2 underwent 12-week All returned in...
Whereas intestinal epithelial barrier dysfunction is implicated in inflammatory bowel disease (IBD), the underlying mechanisms remain elusive. Tumor necrosis factor α stimulated gene 6 (TSG-6) a secretory protein with anti-inflammatory properties. Our previous research demonstrated TSG-6 can relieve inflammation and mucosal damage. However, mechanism targets unclear. This sought to explore how regulates its mechanistic role experimental colitis. IBD mouse model was generated using dextran...
The aim of this study was to investigate the potential associations sites and number specific metastases with survival in patients newly diagnosed cervical cancer.Medical records organ cancer at Zhejiang Cancer Hospital from October 2006 December 2016 were reviewed retrospectively. Survival times compared using Kaplan-Meier method. Variables associated identified univariate multivariate Cox proportional hazards models.A total 99 metastatic identified. Median follow-up 11.6 months (range,...
Abstract Background: WX390 is a highly potent PI3K-mTOR dual inhibitor with activity against PI3Kα, PI3Kδ, and PI3Kγ isoforms, which plays key roles in tumor cells, regulatory T cells (Tregs), myeloid-derived suppressor (MDSCs), respectively, within the microenvironment. PI3K inhibition may enhance anti-tumor efficacy reverse immune resistance combined an anti-PD1 antibody. Preclinical studies showed that modulated microenvironment reversed combination antibody by decreasing amounts of Tregs...
5596 Background: Serous carcinoma represents approximately 10% of all EMC, has the highest recurrence rate and is responsible for a disproportionate 40% mortality in EMC. Additionally, overall 5-year survival only 33% stage III-IV serous carcinoma. Fruquintinib (F, highly selective VEGFR inhibitor) plus sintilimab (S, an anti-PD-1 monoclonal antibody) was evaluated open-label, single-arm phase 2 pivotal study (FRUSICA-1, NCT03903705), demonstrated encouraging efficacy favorable safety...
5509 Background: The phase 3 COMPASSION-16 trial demonstrated statistically significant progression-free survival (PFS) and overall (OS) benefits with cadonilimab plus chemotherapy ± bevacizumab in patients persistent, recurrent, or metastatic cervical cancer (R/M CC). This analysis assessed efficacy several key clinical subgroups. Methods: R/M CC pts who had no prior systemic treatment were randomized 1:1 to receive (10 mg/kg) placebo Q3W platinum-based (15 mg/kg). dual primary endpoints...
5611 Background: FRUSICA-1 (NCT03903705) was an open-label, single-arm, pivotal phase 2 study to evaluate the efficacy and safety of fruquintinib (F, a highly selective VEGFR inhibitor) plus sintilimab (S, anti-PD-1 monoclonal antibody) in previously treated advanced EMC patients (pts) with pMMR (proficient mismatch repair) status. The primary results have demonstrated encouraging (objective response rate [ORR]: 35.6%; median progression-free survival [PFS]: 9.5 mo; overall [OS]: 21.3 mo)...
Human papillomavirus (HPV) are firmly established as the principal causative agent for cervical carcinoma. Current vaccines may provide some protection women from carcinoma linked to HPV genotype 16 and 18. This be best vaccine Western women, but geographical variation in distributions not make it most appropriate China or Asia. study provided an observational, retrospective, hospital-based cross-sectional on distribution of genotypes among 5410 with invasive cancer (ICC) intraepithelial...
Abstract Background To compare adenocarcinoma (AC) and adenosquamous carcinoma (ASC) prognoses in patients with FIGO stage IB–IIA cervical cancer who underwent radical hysterectomy. Methods We performed a retrospective analysis of 240 AC 130 ASC. Kaplan–Meier curves, Cox regression models, log-rank tests were used for statistical analysis. Results Patients ASC had higher frequencies lymphovascular space invasion (LVSI) serum squamous cell antigen (SCC-Ag) > 5 ng/ml ( p = 0.049 0.013,...
An upward trending incidence in cervical adenocarcinoma (ADC) has been reported many countries. Because non-squamous histology associated with increased risk of ovarian metastases (OM), bilateral oophorectomy is commonly performed for ADC without due consideration preservation, degrading the quality life young premenopausal patients.Subjects were patients International Federation Gynecology and Obstetrics (FIGO) stage I-IIB who underwent radical hysterectomy, including pelvic lymphadenectomy...
Immune status is widely acknowledged as a valuable marker for predicting cancer prognosis and therapy response. However, there has been limited understanding of the stromal landscape in cancer.By employing ESTIMATE, stromal- immune-scores were inferred 6193 tumor samples spanning 12 types sourced from The Cancer Genome Atlas (TCGA). Subsequently, categorized into seven groups based on their immune scores. A comparison prognosis, lymphocyte cell infiltration, response to programmed death...
Neuroendocrine cervical carcinoma (NECC) is a rare but aggressive form of cancer representing less than 3% all cases. The objective this study to evaluate the effects clinicopathologic features and treatment modalities on survival patients with NECC. In all, 89 stage I-IV NECC that were diagnosed treated between 2006 2014 at Zhejiang Cancer Hospital retrospectively recruited in study. Kaplan-Meier method, Cox regression analysis models log-rank test used for statistical analyses. advanced...
Objective This study aimed to investigate the clinical and histological features affecting survival of patients with early cervical squamous cell cancer treated radical hysterectomy. Methods We retrospectively analyzed data for stage IB-IIA by hysterectomy at Zhejiang Cancer Hospital from August 2008 January 2013. Results A total 1435 were included in study. Cox regression analysis identified tumor size >4 cm, lymphovascular space involvement (LVSI), lymph node ratio (LNR), carcinoma...
Abstract Vaginal microbiota is closely associated with women's health, however, the correlation between HPV‐related cervical disease (HRCD) and vaginal still obscure. In this study, patients HRCD ( n = 98) healthy controls 58) in Hangzhou were recruited, their collected analyzed. The composition of microbial community was explored, a classification model developed by random forest algorithm. results suggested that diversity significantly higher HRCDs than p < 0.05). Firmicutes dominant...
Currently, cervical adenocarcinoma (ADC) receives the same standard treatment as squamous cell carcinoma, but this regimen is not wholly suited for ADC. The present study was conducted to assess prognostic role of postoperative clinicopathological factors in patients with stage I–IIB examined 312 ADC who underwent radical hysterectomy, including pelvic lymphadenectomy, at our institutions between October 2006 and September 2014. Overall survival (OS) relapse-free (RFS) analyzed by...
To describe the prevalent distribution of human papilloma virus (HPV) infection in patients with early-stage cervical squamous cell carcinoma (CSCC). provide data on high-risk HPV (HR-HPV) and other clinicopathological factors for their correlations survival CSCC patients.A total 1425 FIGO stages IA to IIA who underwent radical surgery between September 2008 December 2012 were enrolled study. The different patient characteristics survivals analyzed or without propensity score matching...