A5090639922- Genetics and Neurodevelopmental Disorders
- Endometrial and Cervical Cancer Treatments
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Glycosylation and Glycoproteins Research
- Endometriosis Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Genetic factors in colorectal cancer
- earthquake and tectonic studies
- Galectins and Cancer Biology
- Minimally Invasive Surgical Techniques
- Moyamoya disease diagnosis and treatment
- Histone Deacetylase Inhibitors Research
- Intraperitoneal and Appendiceal Malignancies
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
Guangxi Medical University
2003-2025
Tumor Hospital of Guangxi Medical University
2009-2024
Zhongshan Hospital
2021-2023
Fudan University
2022-2023
Sun Yat-sen University
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Shanghai University
2022
Shanghai Medical College of Fudan University
2021
Gynecologic Oncology Group
2015
Ovarian Cancer Action
2008-2009
The WW domain-containing oxidoreductase (WWOX) gene is located at FRA16D, a common fragile site involved in human cancer. Targeted deletion of Wwox mice causes increased spontaneous tumor incidence, confirming that WWOX bona fide suppressor gene. We show stable transfection into PEO1 ovarian cancer cells, containing homozygous deletion, abolishes vivo tumorigenicity, but this does not correlate with alteration vitro growth. Rather, restoration PEO1, or overexpression SKOV3 results reduced...
To evaluate pembrolizumab in patients of Chinese descent with microsatellite instability-high (MSI-H)/deficient mismatch repair (dMMR) tumors enrolled KEYNOTE-158 (Cohort L).
The aim of this study was to evaluate serum human epididymis protein 4 (HE4) concentrations for the diagnosis and preoperative prediction optimal debulking in epithelial ovarian cancer. HE4 CA125 180 cancer patients, 40 benign tumor patients healthy female subjects were determined using enzyme‑linked immunosorbent assays (ELISAs). value determining also analyzed. concentration 355.2±221.29 pmol/l cancer, 43.86±20.87 tumors 30.22±9.64 individuals, respectively. levels with significantly...
e17552 Background: There is an unmet need to improve neoadjuvant chemotherapy (NAC) decrease postoperative residual disease (R0 rate: 50%) and prognosis in ovarian cancer (OC). R0 rate histopathological response of interval cytoreductive surgery (IDS) after NAC combined with immune checkpoint blockades were reported be encouraging. Cadonilimab (AK104) a tetravalent bispecific antibody targeting PD-1 CTLA-4. In this study, we report the efficacy safety AK104 patients advanced-stage...
To evaluate the feasibility and surgical outcome of video endoscopic inguinal lymphadenectomy (VEIL) using a hypogastric subcutaneous approach, 21 patients with vulvar cancer who underwent this procedure were included in present study. Between December 2010 March 2013, consecutive radical vulvectomy VEIL approach. The intraoperative post-operative results follow-up data retrospectively analyzed. No complications occurred. mean duration surgery for lymphadenectomies was 130 min (range, 80-180...
<b><i>Objective:</i></b> To evaluate the effectiveness of five methods including ThinPrep cytological test (TCT), liquid-based cytology, human papillomavirus (HPV) test, detection TERC and C-MYC genes visual inspection with acetic acid/Lugol's iodine (VIA/VILI) for opportunistic cervical cancer screening, to explore whether genomic amplification telomerase gene in specimens can be used as a method screening. <b><i>Methods:</i></b> Data were...
The aim of the present study was to determine overall survival (OS) and risk factors associated with early recurrence in patients FIGO I-II stage endometrial carcinoma (EC).Clinical features were retrospectively extracted from database China Endometrial Cancer Consortium January 2000 December 2019. A total 2,974 Federation International Gynecology Obstetrics (FIGO) cancer included. Kaplan-Meier analysis used assess OS disease-specific survival. Cox proportional hazard model Fine-Gray related...
Abstract Homozygous deletions in cancer cells have been thought to harbor tumor suppressor genes. We show that the 25 and 50 kb homozygous WWOX colon cell line HCT116 result from a complex set of heterozygous deletions, some which overlap give loss. One has removed exons 6–8 one allele , there is also third copy distal region an unbalanced translocation. The exon deletion results allele‐specific expression deleted transcript, seems likely be main biological consequence since similar...
Abstract Background Pressurized metered dose inhalers (pMDIs) and dry powder (DPIs) are commonly used drug-delivering devices for patients with chronic airway diseases. Appropriate peak inhalation flow rate (PIFR) inhaler technique is essential effective therapy. We aimed at optimizing therapy through the analysis of PIFRs in obstructive pulmonary disease (COPD) or asthma as well effect training using In-Check DIAL® to help achieve their optimal inspiratory rates. Methods The study...
Objective: To systematically evaluate lymph node metastasis (LNM) patterns in patients with endometrial cancer (EC) who underwent complete surgical staging, which included systematic pelvic and para-aortic lymphadenectomy. Methods: Four thousand one staging including lymphadenectomy for EC were enrolled from 30 centers China 2001 to 2019. We displayed the clinical prognostic characteristics of various LNM patterns, especially PLN-PAN+ [para-aortic (PAN) without (PLN) metastasis]. The...
To investigated the influence of illness perceptions and other risk factors related to poor asthma control quality life in adult outpatients with China. Patients a confirmed diagnosis were recruited from outpatient clinic at Zhongshan Hospital, Fudan University Shanghai. Sociodemographic, psychological, variables assessed all participants. Patients' perceptions, medication adherence, control, using validated questionnaires, such as Brief Illness Perception Questionnaire, Medication Adherence...
First-line bevacizumab plus carboplatin and paclitaxel (CP) is approved for stage III/IV ovarian cancer treatment following initial surgical resection, based on global phase III GOG-0218 ICON7 trials. This study evaluated the efficacy safety of + CP as first-line therapy in Chinese patients.
Follow-up and immunosuppressive medication (ISM) adherence are both important for kidney transplant recipients postoperatively whether follow-up factors affect the ISM remains unclear. The aim of this study was to examine relationship between adherence, associated with adherence.An internet-based cross-sectional survey conducted in a single center China. participants completed questionnaire Basel Assessment Adherence Immunosuppressive Medication Scale (BAASIS©) from January 12 26,...
Objective: To evaluate the short-term and long-term outcomes after laparoscopic surgery compared with traditional laparotomy in cases of stage ⅠA2-ⅡA2 cervical cancer. Methods: We conducted a retrospective study on clinical data 1 863 patients diagnosed as FIGO stages cancer 6 third-grade class-A hospitals Guangxi province between January 2007 May 2014. One thousand seventy-one received laparoscopy, 792 laparotomy. T-test, U-test χ(2) test were used to compare outcomes. The included surgical...