A5003806796- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Multiple and Secondary Primary Cancers
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
Ganzhou People's Hospital
2022-2025
Guangdong Provincial People's Hospital
2018-2025
Gannan Medical University
2022-2025
Guangdong Academy of Medical Sciences
2016-2025
Southern Medical University
2009-2025
South China University of Technology
2018-2025
Tianjin Medical University Cancer Institute and Hospital
2025
Shantou University
2020-2024
Shantou University Medical College
2020-2024
Guangdong General Hospital
2016-2021
In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC) and well-matched liver metastatic CRC using single-cell spatial transcriptome RNA sequencing. We generated 41,892 CD45 − nonimmune cells 196,473 + immune from 27 samples six patients, found that CD8_CXCL13 CD4_CXCL13 subsets increased significantly in exhibited high proliferation ability tumor-activating characterization, contributing to better prognosis patients. Distinct fibroblast profiles were...
Abstract The tumor microenvironment is a complex ecosystem formed by distinct and interacting cell populations, its composition related to cancer prognosis response clinical treatment. In this study, we have taken the advantage of two single‐cell RNA sequencing technologies (Smart‐seq2 DNBelab C4) generate an atlas 15,115 immune nonimmune cells from primary tumors hepatic metastases 18 colorectal (CRC) patients. We observed extensive changes in proportions functional states T B tissues,...
Liver metastasis is one of the major causes colorectal cancer (CRC)-related morbidity and mortality. Delivering small interfering RNAs (siRNAs) or noncoding has been reported as a promising method to target liver chemoresistance in CRC. Here, we report RNA delivery system using exosomes derived from primary patient cells. Coiled-coil domain-containing protein 80 (CCDC80) was strongly associated with CRC chemoresistance, finding validated by bioinformatic analysis clinical specimens....
Stomach adenocarcinoma (STAD) with microsatellite instability (MSI) is associated a better prognosis compared to Non-MSI. This study aims elucidate the differences in tumor microenvironment (TME) of MSI and explore its underlying mechanisms STAD. TME between Non-MSI were analyzed using single-cell RNA sequencing (MSI = 7, 19) bulk 39, 198). Differentially expressed genes (DEGs) used identify enriched pathways hub genes. TNFSF9 expression was validated by immunohistochemistry (IHC) on 23 STAD...
Background: Recently, multiple lines of evidence have demonstrated that linc00662 serves as an oncogene in various cancers. However, the exact mechanism oncogenesis mediated by colorectal cancer (CRC) remains unknown. In this study, we aimed to explore biological role regulation CRC progression. Methods: Both gene expression omnibus (GEO) and genome atlas (TCGA) datasets were used evaluate linc00662. RT-qPCR was analyze linc00662, miR-497-5p, AVL9 clinical samples cell lines. Cell Counting...
Multidrug resistance (MDR) is one of the primary causes chemotherapy failure in colorectal cancer (CRC), and extensive biological studies into MDR are required. The non‑coding RNA plasmacytoma variant translocation 1 (PVT1) has been demonstrated to be associated with low survival rates patients CRC. However, whether PVT1 serves a critical function CRC remains determined. To determine association between expression 5‑fluorouracil (5‑FU) CRC, levels mRNA 5‑FU‑resistant tissues cell lines...
Long non-coding RNA (lncRNA) plays a very important role in the occurrence and development of various tumors, is potential biomarker for cancer diagnosis prognosis. The purpose this study was to investigate relationship between expression lncRNA plasmacytoma variant translocation 1 (PVT1) prognostic significance patients with colorectal cancer.The PVT1 measured by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) cancerous adjacent tissues 210 patients....
Existing cohort studies show no association between insulin use and cancers of the digestive system, while numerous meta-analyses suggest that increases risk system tumours. This study uses two-sample Mendelian randomization (MR) to further investigate causal relationship two. We selected single nucleotide polymorphisms (SNPs) strongly associated with as instrumental variables used aggregated statistics on neoplasms outcome event. The primary method analysis was inverse variance weighting...
Disulfidptosis is a unique type of programmed cell death that distinct from previously known forms death, such as pyroptosis, apoptosis, and necroptosis. Researchers have studied the significance many in various diseases, particularly malignant tumors, great detail recent years. Therefore, how disulfidptosis affects colon cancer it functions immune system are unknown. Disulfidptosis-related gene (DRG) expression information was obtained TCGA-COAD cohort. Patients were categorized into two...
Nicotinamide plays a critical role in the prevention and treatment of tumors, its metabolism is closely associated with tumor progression. The aim this study was to understand prognostic immunological significance nicotinamide metabolism-related genes pan-cancer. We downloaded Cancer Genome Atlas Genotype Tissue Expression pan-cancer datasets for NMNAT1 from UCSC database. analyzed differential expression, prognosis, genetic alterations, DNA methylation, immune infiltration, co-expression...
Abstract Antiangiogenic therapies, such as bevacizumab, are among the causes of cancer‐related death in patients with colorectal cancer (CRC) liver metastasis. Delivering siRNAs via primary cell originating from cells is a promising method for targeting CRC metastasis and drug resistance. Here, it found that expression CCL24 significantly upregulated tumor tissues at site. In addition, bevacizumab‐resistant patients. promotes formation inflammatory tumor‐associated fibroblast subsets...
The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and predictive potential of for responding immunotherapy CRC.We analyzed genes CRC concomitant or without microsatellite instability (MSI) using TCGA dataset investigated profiles pathway cBioPortal. scores cell infiltration different groups were calculated. We applied Kaplan-Meier method survival analysis patients who...
The characteristics of colorectal cancer (CRC) vary depending on the level study and clinical application. current proposed a novel subtype, Human papillomavirus (HPV)-infected CRC, to understand impact HPV CRC. We assessed prevalence implications in CRC by integrating single cohort Guangdong Provincial People's Hospital public dataset. Differential gene, pathway enrichment analysis, immune infiltration analysis were conducted explore patterns HPV-infected Quantitative polymerase chain...
In the present study, we investigated role of salt-induced kinase 1 (SIK1), a serine/threonine protein, in colorectal cancer (CRC).Despite reported association SIK1 with tumor malignancy suppression various cancers, limited research has been conducted on its function CRC.Our findings revealed that expression was low CRC cells.The results KEGG pathway analysis showed strong between and TGF-β signaling pathway.In addition, coimmunoprecipitation assay validated interaction Smad7.Our data...