A5066365496- Autophagy in Disease and Therapy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Endoplasmic Reticulum Stress and Disease
- Bone health and osteoporosis research
- Medical Imaging and Analysis
- Head and Neck Surgical Oncology
- Advanced X-ray and CT Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone health and treatments
- Gastric Cancer Management and Outcomes
- Hematopoietic Stem Cell Transplantation
- Cervical and Thoracic Myelopathy
- Acute Myeloid Leukemia Research
- Esophageal Cancer Research and Treatment
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- Bone Metabolism and Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal pain and rehabilitation
- Cardiac electrophysiology and arrhythmias
- Spinal Hematomas and Complications
- Gastrointestinal Tumor Research and Treatment
Chinese University of Hong Kong
2024-2025
Prince of Wales Hospital
2024-2025
Peking University
2015-2025
Nanjing Medical University
2024-2025
Guangxi Medical University
2022-2025
Dalian Medical University
2023-2025
First Affiliated Hospital of Dalian Medical University
2025
Peking University Third Hospital
2015-2025
Fujian Provincial Cancer Hospital
2025
Fujian Medical University
2024-2025
Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental detection associated with prolonged survival, but screening asymptomatic individuals for PDAC using a single test remains unfeasible due to low prevalence potential harms of false positives. Non-contrast computed tomography (CT), routinely performed clinical indications, offers large-scale screening, however, identification non-contrast CT has...
The globally prevalent rotator cuff tear has a high re-rupture rate, attributing to the failure reproduce interfacial fibrocartilaginous enthesis. Herein, hierarchically organized membrane is developed that mimics heterogeneous anatomy and properties of natural enthesis finely facilitates reconstruction tendon-bone interface. A biphasic consisting microporous layer mineralized fibrous constructed through non-solvent induced phase separation (NIPS) strategy followed by co-axial...
Abstract Intracellular pH plays an important role in the response to cancer invasion. We have designed and synthesized a series of new fluorescent probes (Superior LysoProbes) with capacity label acidic organelles monitor lysosomal pH. Unlike commercially available dyes, Superior LysoProbes are lysosome-specific highly stable. The use facilitates direct visualization lobaplatin elicited human chloangiocarcinoma (CCA) RBE cells, using confocal laser scanning microscopy. Additionally, we...
Licochalcone A (LCA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, presents obvious anti-cancer effects. In this study, effects and potential mechanisms of LCA in non-small cell lung cancer (NSCLC) cells were studied. decreased viability, increased lactate dehydrogenase release, induced apoptosis concentration-dependent manner NSCLC while not human embryonic fibroblast cells. The expression phosphatidylethanolamine-modified microtubule-associated...
To develop and validate a radiomics prediction model for individualized of perineural invasion (PNI) in colorectal cancer (CRC). After computed tomography (CT) features extraction, signature was constructed derivation cohort (346 CRC patients). A developed to integrate the clinical candidate predictors [age, sex, tumor location, carcinoembryonic antigen (CEA) level]. Apparent performance assessed. internal validation, independent temporal validation (separate from used build model) then...
Abstract The healing of bone defects after debridement in medication‐related osteonecrosis the jaw (MRONJ) is a challenging medical condition with impaired angiogenesis, susceptible infection, and pro‐inflammatory responses. Magnesium (Mg) nanocomposite hydrogel developed to specifically tackle multiple factors involved MRONJ. Mg‐oxide nanoparticles tune gelation kinetics reaction between N‐hydroxysuccinimide‐functionalized hyperbranched poly (ethylene glycol) proteins. This allows an...
Background: Lymph node (LN) metastasis is the most important prognostic factor in esophageal squamous cell carcinoma (ESCC). Traditional clinical and existing methods based on CT images are insufficiently effective diagnosing LN metastasis. A more efficient method to predict status image needed. Methods: In this multicenter retrospective study, 411 patients with pathologically confirmed ESCC were registered from two hospitals. Quantitative features including handcrafted-, computer...
Background: Recently, multiple lines of evidence have demonstrated that linc00662 serves as an oncogene in various cancers. However, the exact mechanism oncogenesis mediated by colorectal cancer (CRC) remains unknown. In this study, we aimed to explore biological role regulation CRC progression. Methods: Both gene expression omnibus (GEO) and genome atlas (TCGA) datasets were used evaluate linc00662. RT-qPCR was analyze linc00662, miR-497-5p, AVL9 clinical samples cell lines. Cell Counting...
Apoptosis of gastric mucosa epithelial cells caused by the abuse alcohol produces injury to and acute or chronic gastritis. In recent years, it has been demonstrated that endoplasmic reticulum stress (ERS) is involved in mediating apoptosis, autophagy a protective effect on survival cells. Rebamipide mucosal protectant used treat gastritis stomach ulcers. this study, ethanol was overstimulate gavage mice. It found 400 mmol/L overstimulation could activate ERS induce apoptosis (control vs...
The potential critical windows for extreme ambient temperature, air pollution exposure and small gestational age (SGA) are still unclear, no study has explored their joint effects on SGA. In a national multi-center prospective cohort, we included 179,761 pairs of mother-infant from 16 counties 8 provinces in China during 2014–2018. Daily averaged temperature PM2.5 concentration were matched to the maternal residential address estimate personal exposure. Extreme exposures categorized by...
The HECT E3 ubiquitin ligase HACE1 is a tumour suppressor known to regulate Rac1 activity under stress conditions. increased in the serum of patients with heart failure. Here we show that protects pressure by controlling protein degradation. Hace1 deficiency mice results accelerated failure and mortality haemodynamic stress. Hearts from Hace1(-/-) display abnormal cardiac hypertrophy, left ventricular dysfunction, accumulation LC3, p62 ubiquitinated proteins enriched for cytoskeletal...
Low responsiveness to chemotherapy is an important cause of poor prognosis in pancreatic cancer. Smoking a high-risk factor for cancer and resistance gemcitabine; however, the underlying mechanisms remain unclear. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) main metabolite tobacco burning has been shown be associated with development chemoresistance. However, cancer, its mechanism remains poorly understood. In this study, we found that NNK promoted stemness gemcitabine cell lines....
Strontium ranelate (SR) is a pharmaceutical agent used for the prevention and treatment of osteoporosis fragility fracture. However, little attention has been paid to effect SR on alveolar bone remodeling during orthodontic tooth movement its underlying mechanism. Here, we investigated influence resorption in Sprague-Dawley rats relationship between nuclear factor-kappa B (NF-κB) pathway, autophagy, osteoclastogenesis after administration vitro vivo. In this study, it was found that reduced...