A5009066765- Sexual function and dysfunction studies
- Sexuality, Behavior, and Technology
- Hormonal and reproductive studies
- Kidney Stones and Urolithiasis Treatments
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Adenosine and Purinergic Signaling
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Renal and related cancers
- Ureteral procedures and complications
- Acute Kidney Injury Research
- Neurological Complications and Syndromes
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Heme Oxygenase-1 and Carbon Monoxide
- Renal cell carcinoma treatment
- Urinary Tract Infections Management
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Neonatal Health and Biochemistry
Second Affiliated Hospital of Zhejiang University
2015-2025
Dalian Maritime University
2022-2023
University of Amsterdam
2018-2020
Weatherford College
2020
Creative Commons
2020
Zhejiang University
2015
University of Houston
2012
The University of Texas Health Science Center at Houston
2009-2012
Third Xiangya Hospital
2009-2011
Central South University
2009-2011
The clear cell renal carcinoma (ccRCC) microenvironment consists of many different types and structural components that play critical roles in cancer progression drug resistance, but the cellular architecture underlying gene regulatory features ccRCC have not been fully characterized. Here, we applied single-cell RNA sequencing (scRNA-seq) assay for transposase-accessible chromatin (scATAC-seq) to generate transcriptional epigenomic landscapes ccRCC. We identified tumor cell-specific...
A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute injury (AKI) — life-threatening condition that frequently complicates the care hospitalized patients. Therapeutic approaches to prevent and treat AKI are extremely limited. Better understanding molecular pathways promoting postischemic reflow could provide new candidate targets for therapeutics. Due its role in adapting...
Chronic elevation of adenosine, which occurs in the setting repeated or prolonged tissue injury, can exacerbate cellular dysfunction, suggesting that it may contribute to pathogenesis CKD. Here, mice with chronically elevated levels resulting from a deficiency adenosine deaminase (ADA), developed renal dysfunction and fibrosis. Both administration polyethylene glycol-modified ADA reduce inhibition A(2B) receptor (A(2B)R) attenuated fibrosis dysfunction. Furthermore, activation A(2B)R...
Abstract Background Previous epidemiological observational studies have potentially associated psoriasis with bladder cancer, but the results are inconsistent, and causality remains unknown. The present study aimed to examine whether there causal associations between cancer using bidirectional two‐sample Mendelian randomization (MR) analysis. Materials Methods A MR analysis was conducted publicly available genome‐wide association (GWAS) data for individuals diagnosed cancer. inverse variance...
Abstract Acute Kidney Injury (AKI) is a significant medical condition characterized by the abrupt decline in kidney function.Low‐intensity pulsed ultrasound (LIPUS), non‐invasive therapeutic technique employing low‐intensity acoustic wave pulses, has shown promise promoting tissue repair and regeneration. A novel LIPUS system was developed evaluated rat AKI models, focusing on its effects glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), Notch1‐Akt‐eNOS...
Preeclampsia is a prevalent life-threatening hypertensive disorder of pregnancy. The circulating antiangiogenic factor, soluble endoglin (sEng), elevated in the blood circulation women with preeclampsia and contributes to disease pathology; however, underlying mechanisms responsible for its induction are unknown.Here, we discovered that autoantibody, angiotensin receptor agonistic autoantibody (AT(1)-AA), stimulates sEng production via AT(1) activation pregnant mice but not nonpregnant mice....
Priapism is a condition of persistent penile erection in the absence sexual excitation. Of men with sickle cell disease (SCD), 40% display priapism. The disorder dangerous and urgent condition, given its association fibrosis eventual erectile dysfunction. Current strategies to prevent progression are poor because lack fundamental understanding molecular mechanisms for Here we demonstrate that increased adenosine novel causative factor contributing two independent animal models priapism,...
Normal penile erection is under the control of multiple factors and signaling pathways. Although adenosine implicated in normal abnormal erection, exact role underlying mechanism for physiology remain elusive. Here we report that shear stress leads to increased release from endothelial cells. Subsequently, determined ecto-5'-nucleotidase (CD73) a key enzyme required production elevated ATP released by shear-stressed Mechanistically, demonstrate stress-mediated functions through A2B receptor...
Priapism is featured with prolonged and painful penile erection prevalent among males sickle cell disease (SCD). The disorder a dangerous urological hematological emergency since it associated ischemic tissue damage erectile disability. Here we report that phosphodiesterase-5 (PDE5) gene expression PDE activity significantly reduced in tissues of two independent priapic models: SCD mice adenosine deaminase (ADA)-deficient mice. Moreover, using ADA enzyme therapy to reduce or specific...
The serine/threonine kinases, Rho‑associated protein kinase I and II (ROCK II), regulate the cytoskeleton by acting downstream of small GTPase, Rho, have been implicated in tumorigenesis cancer metastasis. Inhibition ROCK signaling has shown to suppress invasion migration several types cells. In this study, effect inhibitor, Y‑27632, on proliferation T24 5637 bladder cells was investigated. assays, were exposed 0, 10, 25, 50, 75, 100, 125 or 150 µmol/l Y‑27632 determined using Cell Counting...
Objective: To compare the clinical efficacy and safety between diode laser (980 nm) enucleation of prostate (DiLEP) holmium (HoLEP) for treating benign prostatic hyperplasia (BPH). Patients Methods: One hundred twenty-six BPH patients in our hospital from December 2016 to 2017 were enrolled this study. They randomized DiLEP group or HoLEP group, which administrated with treatment, respectively. The patient's characteristics, such as age, body mass index, comorbidities, volume,...
Abstract Time-lapse fluorescence imaging of live cells at super-resolution remains a challenge, especially when the photon budget is limited. Current techniques require either use special exogenous probes, high illumination doses or multiple image acquisitions with post-processing combinations aforementioned. Here, we describe new approach by combining annular rescan confocal microscopy. This optics-only technique generates images in single scan, thereby avoiding any potential risks...
Spermatogenesis is a highly coordinated physiological process that requires the correct expression and functions of thousands developmentally regulated genes. The regulation spermatogenesis not well defined, since majority related genes have neither been identified nor fully characterized. Hence, it meaningful to identify characterize these reveal mechanism underlying spermatogenesis. In this study, using digital differential display, we novel human testis-specific gene, testis developmental...
Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cell (TEC) inflammatory and oxidative injury. This study is aimed at exploring potential therapeutic lipid components in kidney stones because lipids are involved the development of several diseases indicate risk stones. Serum specimens were collected from 35 stone patients normal controls. The serum measured, differences analyzed. documented biological importance was comprehensively reviewed to identify that differed...
Transurethral resection of the prostate (TURP) was considered golden standard to treat benign prostatic hyperplasia (BPH) for decades. However, TURP associated with low efficiency alleviate lower urinary tract symptoms (LUTS) and a significantly higher risk bladder neck contracture (BNC) patients small-volume BPH. Our study aims compare therapeutic effect transurethral split (TUSP) BPH (<30 mL).In this study, 101 were randomly divided into two groups (TUSP group). The patient's baseline...