A5100707258- Chronic Kidney Disease and Diabetes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Inflammasome and immune disorders
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Renal Diseases and Glomerulopathies
- Connective Tissue Growth Factor Research
- Heme Oxygenase-1 and Carbon Monoxide
- Renal and Vascular Pathologies
- Kidney Stones and Urolithiasis Treatments
- Sulfur Compounds in Biology
- Drug-Induced Hepatotoxicity and Protection
- Pregnancy and preeclampsia studies
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- TGF-β signaling in diseases
- Dialysis and Renal Disease Management
- Cancer-related gene regulation
- Pediatric Urology and Nephrology Studies
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cardiac Fibrosis and Remodeling
- Glutathione Transferases and Polymorphisms
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Affiliated Hospital of Taishan Medical University
2018
Changsha Medical University
2011-2017
Chinese University of Hong Kong
2016
Third Xiangya Hospital
2011-2016
Yale University
2013-2016
Laboratoire de Génétique Médicale
2016
University of Colorado Denver
2013-2015
Arkana Laboratories
2015
Chronic kidney disease (CKD) is a prevalent life-threatening frequently associated with hypertension, progression to renal fibrosis, and eventual failure. Although the pathogenesis of CKD remains largely unknown, an increased inflammatory response known be has long been speculated contribute development. However, causative factors, exact role cascade in CKD, underlying mechanisms for its remain unidentified. Here we report that interleukin 6 (IL-6) expression levels were significantly...
Glucagon-like peptide 1 (GLP-1) increases tissue glucose uptake and causes vasodilation independent of insulin. We examined the effect GLP-1 on muscle microvasculature uptake. After confirming that potently stimulates nitric oxide (NO) synthase (NOS) phosphorylation in endothelial cells, overnight-fasted adult male rats received continuous infusion (30 pmol/kg/min) for 2 h plus or minus NOS inhibition. Muscle microvascular blood volume (MBV), flow velocity (MFV), (MBF) were determined....
Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance negative regulation inflammasomes remains poorly understood. Here, we show that E3 ubiquitin ligase Cbl-b is essential for preventing endotoxemia induced by a sub-lethal dose LPS via caspase-11/NLRP3–dependent manner. Further studies undergoes both K63- and K48-linked polyubiquitination. binds K63-ubiquitin chains attached leucine-rich repeat domain (LRR) its ubiquitin-associated region (UBA)...
Abstract Interleukin ( IL )‐1β plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The production ‐1β is dependent upon caspase‐1‐containing multiprotein complexes called inflammasomes and ‐1R1/MyD88/ NF ‐κB pathway. In this study, we explored whether a potential anti‐fibrotic agent fluorofenidone FD ) exerts its anti‐inflammatory effects through suppressing activation NACHT, LRR PYD domains‐containing protein 3 (NALP3) inflammasome ‐1β/ pathway vivo vitro . Male...
Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed investigate association of NLR with progression end stage (ESRD), (CVD) all-cause mortality Chinese patients stages 1-4 CKD.Patients CKD (18-74 years age) were recruited at 39 centers 28 cities across 22 provinces China since 2011. A total 938 complete other...
Damage-associated molecular patterns (DAMPs) are a cause of acute kidney injury (AKI). Our knowledge these DAMPs remains incomplete. Here, we report serum peroxiredoxin 1 (Prdx1) as novel DAMP for AKI. Lipopolysaccharide (LPS) and ischemia/reperfusion instigated AKI with concurrent increases in Prdx1 reductions expression tubular epithelial cells. Genetic knockout or use Prdx1–neutralizing antibody protected mice from this protection was impaired by introduction recombinant (rPrdx1)....
Hypertension is the most prevalent life-threatening disease worldwide and frequently associated with chronic kidney (CKD). However, molecular basis underlying hypertensive CKD not fully understood. We sought to identify specific factors signaling pathways that contribute thereby exacerbate progression. Using high-throughput quantitative reverse-transcription polymerase chain reaction profiling, we discovered expression level of 5'-ectonucleotidase (CD73), a key enzyme produces extracellular...
Highlights•Vascular calcification (VC) develops in patients with chronic kidney disease (CKD).•VC occurs early CKD (ECKD) without an elevation serum phosphorus.•Oxidative stress (OS) ECKD is causative factor of VC.•Serum induces calcium deposition vascular smooth muscle cells.•Inhibition OS protects VSMCs from induced by patient serum.AbstractVascular a major cause mortality (CKD). While elevations phosphorus contribute to VC, we provide evidence here for role oxidative VC pathogenesis...
Background Sepsis-associated acute kidney injury (S-AKI) is considered to be associated with high morbidity and mortality, a commonly accepted model predict mortality urged consequently. This study used machine learning identify vital variables in S-AKI patients the hospital risk of death hospital. We hope that this can help high-risk early reasonably allocate medical resources intensive care unit (ICU). Methods A total 16,154 from Medical Information Mart for Intensive Care IV database were...
Metabolic dysfunction-associated steatohepatitis (MASH), a severe form of metabolic steatotic liver disease (MASLD), involves hepatic lipid accumulation, inflammation, and fibrosis. It can progress to cirrhosis or hepatocellular carcinoma without timely treatment. Current treatment options for MASH are limited. This study explores the therapeutic effects fluorofenidone (AKF-PD), novel small-molecule compound with antifibrotic anti-inflammatory properties, on in mouse model. Mice fed...
Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy associated with increased complement activation. However, the causative factors and pathogenic role activation in PE are largely unidentified. Here we report that circulating maternal autoantibody, angiotensin II type 1 receptor agonistic which emerged recently as potential contributor to PE, stimulates deposition C3 placentas kidneys pregnant mice via Next, provide vivo evidence selectively interfering C3a...
Hypertensive chronic kidney disease is one of the most prevalent medical conditions with high morbidity and mortality in United States worldwide. However, early events initiating progression to hypertensive are poorly understood. We hypothesized that elevated endothelial hypoxia-inducible factor-1α (HIF-1α) a common insult triggering initial glomerular injury leading disease. To test our hypothesis, we used an angiotensin II infusion model determine specific cell type mechanisms responsible...
Diabetic kidney disease (DKD) is a major cause of end stage renal diseases worldwide. Despite successive interventions for delaying the progression DKD, current treatments cannot reverse pathological progression. Mefunidone (MFD) new compound with potent antifibrotic properties, but effect MFD on DKD remains unknown. Therefore, we investigated protective effects in both models db/db type 2 diabetes (T2D) and streptozotocin (STZ)-induced 1 (T1D) models. Compared model group, treatment...
Acute liver failure (ALF) is a life-threatening disease characterized by abrupt and extensive hepatic necrosis apoptosis, resulting in high mortality. The approved drug, N-acetylcysteine (NAC), only effective for acetaminophen (APAP)-associated ALF at the early stage. Thus, we investigate whether fluorofenidone (AKF-PD), novel antifibrosis pyridone agent, protects against mice explore its underlying mechanisms.ALF mouse models were established using APAP or lipopolysaccharide/D-galactosamine...
Diabetic retinopathy (DR) is one of the most common diabetic eye diseases and a leading cause blindness. It characterized by changes in blood vessels retina. The pathogenesis DR complex to date, precise mechanisms involved remain unclear. Previous studies have reported that associated with neurodegeneration apoptosis may occur retinas. In present study, retinal neurons under conditions hyperglycemia were used as model study Retinal exposed exhibited high levels apoptosis. Brain‑derived...
Abstract Previously, we demonstrated that CD28 and CTLA-4 signaling control Casitas-B-lineage lymphoma (Cbl)-b protein expression, which is critical for T cell activation tolerance induction. However, the molecular mechanism(s) of this regulation remains to be elucidated. In study, found Cbl-b fails undergo tyrosine phosphorylation upon CD3 stimulation because SHP-1 recruited dephosphorylates Cbl-b, whereas costimulation abrogates interaction. support finding, cells lacking display...
Mitochondrial damage contributes to extracellular matrix (ECM) deposition and renal fibrosis. In this study, we aimed (1) investigate whether fluorofenidone (AKF-PD) can attenuate mitochondrial in two fibrosis models: unilateral ureteral obstruction (UUO) ischemia-reperfusion injury (IRI), (2) explore the underlying mechanism. lesions were analyzed UUO IRI models. energy metabolism, biogenesis, oxidative stress measured assess effect of AKF-PD on addition, HK-2 cells stimulated with TGF-β...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main cause of COVID-19, causing hundreds millions confirmed cases and more than 18.2 million deaths worldwide. Acute kidney injury (AKI) a common complication COVID-19 that leads to an increase in mortality, especially intensive care unit (ICU) settings, chronic disease (CKD) high risk factor for its related mortality. However, underlying molecular mechanisms among AKI, CKD, are unclear. Therefore, transcriptome analysis was...