A5058914310- Advanced Radiotherapy Techniques
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Surgical Simulation and Training
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Tuberculosis Research and Epidemiology
- Ferroptosis and cancer prognosis
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- HER2/EGFR in Cancer Research
- Radiation Dose and Imaging
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Soft Robotics and Applications
- Cancer, Hypoxia, and Metabolism
- Orthopaedic implants and arthroplasty
- Peptidase Inhibition and Analysis
Xiangya Hospital Central South University
2021-2025
Central South University
2021-2025
Hunan University
2023-2025
Shanghai Jiao Tong University
2025
Renji Hospital
2025
Zymeworks (Canada)
2025
Beijing Chest Hospital
2012-2024
Shandong Tumor Hospital
2010-2024
Harbin Medical University
2022-2024
Shandong First Medical University
2010-2024
Here, we ascertained the clinical characteristics of Chinese patients with autoimmune gastritis (AIG) and determined correlation dietary lifestyle factors AIG occurrence development to establish a noninvasive predictive model for AIG. In this case-control study, enrolled 479 from seven independent centers nationwide in China; them, 279 had AIG, 112 chronic atrophic mostly antrum, 88 nonatrophic gastritis. Their data were systematically collected analyzed. Finally, multivariate logistic...
Metabolic dysfunction-associated steatohepatitis (MASH), a severe form of metabolic steatotic liver disease (MASLD), involves hepatic lipid accumulation, inflammation, and fibrosis. It can progress to cirrhosis or hepatocellular carcinoma without timely treatment. Current treatment options for MASH are limited. This study explores the therapeutic effects fluorofenidone (AKF-PD), novel small-molecule compound with antifibrotic anti-inflammatory properties, on in mouse model. Mice fed...
Radioresistance and immunosuppression remain the major obstacles in anti-cancer treatments. This work studies functions of sialic acid binding Ig like lectin 9 (SIGLEC9) its related molecules radioresistance esophageal squamous cell carcinoma (ESCC). The single-cell analysis showed that SIGLEC9 was mainly expressed on tumor-associated macrophages (TAMs). Monocytes-derived were co-cultured with ESCC cells subjected to radiotherapy. High or low doses radiotherapy induced upregulation M2...
Purpose The purpose of this study is to systematically analyze the relationships between green supply chain management (GSCM), enterprise environmental performance (EEP) and moderating role market environment, regional culture, sampling area industry type. Design/methodology/approach This constructed a comprehensive theoretical model used meta-analysis 65 independent samples (total sample size: 14,196) examine GSCM EEP. Findings results show that has moderate positive impact on Moreover, all...
Abstract Lung adenocarcinoma (LUAD) is a malignant tumor with high lethality, and the aim of this study was to identify promising biomarkers for LUAD. Using TCGA-LUAD dataset as discovery cohort, novel joint framework VAEjMLP based on variational autoencoder (VAE) multilayer perceptron (MLP) proposed. And Shapley Additive Explanations (SHAP) method introduced evaluate contribution feature genes classification decision, which helped us develop biologically meaningful biomarker potential...
Abstract Understanding the factors that govern human forebrain regionalization along dorsal–ventral and left–right (L‐R) axes is likely to be relevant a wide variety of neurodevelopmental neuropsychiatric conditions. Recent work in lower vertebrates has identified several critical signaling molecules involved embryonic patterning these axes. Among are Wingless‐Int (WNT) proteins, formation dorsal central nervous system (CNS) structures, as well visceral L‐R asymmetry. We examined expression...
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. receptor (ER) expression is associated with microRNA (miRNA) in ER-positive tumors. However, studies of direct link between estrogen (especially estradiol E2), miRNA expression, and MMR colorectal (CRC) have not been done. In this study, we first evaluated the (E2) its antagonist ICI182,780 on miRNAs (miR-31, miR-155 miR-135b) using COLO205, SW480 MCF-7 cell lines, followed...
We aimed to investigate the association between systemic immune-inflammation index (SII) and clinical outcomes in patients with advanced non-small-cell lung cancer.The SII was calculated as platelet (P) × neutrophil (N)/lymphocyte (L), data were obtained within 1 week before treatment. Kaplan-Meier analysis Cox proportional hazard models used assess prognostic value of SII.Kaplan-Meier analyses revealed that higher group associated poorer progression-free survival (p < 0.001) overall 0.001)....
Abstract Ly6E (lymphocyte antigen 6 family member E) is a GPI anchored cell surface protein frequently expressed in number of cancers such as TNBC, NSCLC, HNSCC, ESCC, OVCA, and PDAC, with minimal presence normal tissues. ZW327 an antibody-drug conjugate (ADC) targeting human Ly6E, composed humanized IgG1 antibody bearing Fc-silencing mutations, conjugated to novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via maleimide anchor glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM)...
Abstract Background: Biparatopic antibodies and antibody-drug conjugates (ADCs) can provide many functional benefits over their traditional monoparatopic counterparts including increased binding, greater cell surface decoration, superior receptor blockade, enhanced internalization payload delivery; however, not all antigens are amenable to biparatopic targeting. We sought leverage our prior knowledge of antibody development AzymetricTM technology develop a novel ADC against protein tyrosine...
The functions of estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2) and Ki-67 in breast cancer have been explored. This study was carried out to explore ER, PR, HER-2 expression levels patients their relationship with ultrasound signs prognosis.A total 274 female primary received preoperative examination. tissues were detected by immunohistochemical staining after surgery. correlations prognosis analyzed.The positive rate PR high 73.36% (201/274), 59.85%...
8014 Background: The phase 3 trial (CAPSTONE-1) showed that adebrelimab (PD-L1 antibody) combined with first-line chemotherapy could prolong overall survival (OS) in patients (pts) extensive-stage small cell lung cancer (ES-SCLC). Previous studies have shown radiotherapy can enhance the immunogenicity of tumors, indicating great potential combining immunotherapy. purpose this study was to explore efficacy and safety sequential thoracic (TRT) as therapy for ES-SCLC. Methods: Key inclusion...
To explore the relationships between primary tumor 18F-FDG uptake measured as SUVmax and local extension, nodal or distant organ metastasis in patients with NSCLC on pretreatment PET-CT.93 who underwent PET-CT scans before treatment were included study. Primary was calculated; clinical stages, presence of metastases recorded. The ≥ 2.5 divided into low high groups by using median SUVmax. group consisted 45 SUVmax<10.5, 46 10.5. Their data compared statistically.91 cases SUVmax≥2.5 for...
To assess the activity of clofazimine (CFZ) against Mycobacterium tuberculosis persisters using an oxygen depletion model and a low-dose aerosol mouse chronic (TB).In in vitro experiments, CFZ showed much better than isoniazid under anaerobic conditions. In TB, we evaluated efficacy moxifloxacin at different doses following treatment durations 30, 60 90 days.CFZ significant bactericidal over wide dose range 2-200 mg/kg. was dose-dependent. The bacilli were eradicated 200 mg/kg group after...
Background Recent evidence highlights the fact that immunotherapy has significantly improved patient outcomes. CD93, as a type I transmembrane glycoprotein, was correlated with tumor-associated angiogenesis; however, how CD93 correlates in stomach adenocarcinoma (STAD) remains unclear. Methods TCGA, GTEx, GEO, TIMER2.0, HPA, TISIDB, TCIA, cBioPortal, LinkedOmics, and ImmuCellAI public databases were used to elucidate STAD. Visualization statistical analysis of data performed by R (Version...
Despite its high case-fatality risk, pyogenic liver abscess (PLA) lacks clear management guidelines in patients with negative microbial cultures. Our aim was to evaluate differences clinical characteristics between culture-negative (CNLA) and those culture-positive (CPLA), identify the main causative pathogen.In this study, we retrospectively collected medical records of PLA admitted a teaching hospital from January 2010 December 2019.In total, 324 were enrolled study. Of these, 202 (62.3%)...