A5110688683- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Hepatitis B Virus Studies
- Parkinson's Disease Mechanisms and Treatments
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer therapeutics and mechanisms
- Breast Lesions and Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Bladder and Urothelial Cancer Treatments
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Artificial Intelligence in Healthcare
- RNA regulation and disease
Suzhou Institute of Nano-tech and Nano-bionics
2025
Chinese Academy of Sciences
2025
Shandong First Medical University
2016-2025
Academy of Medical Sciences
2021-2025
Shandong Tumor Hospital
2016-2025
Wuhan Union Hospital
2024
Wuhan University of Science and Technology
2024
Shanghai First People's Hospital
2024
Nanchang University
2022-2024
Guangzhou University of Chinese Medicine
2024
Tumor angiogenesis is one of the typical hallmarks tumor occurrence and development, neovascularization also exhibits distinct characteristics from normal blood vessels. As number cells matrix inside increases, biomechanical force enhanced, specifically manifested as solid stress, fluid stiffness, topology. This mechanical microenvironment provides shelter for tumors intensifies angiogenesis, providing oxygen nutritional support progression. During emerges, which in turn feeds back to...
synucleinopathies are diseases characterized by the aggregation of α-synuclein (α-syn), which forms fibrils through misfolding and accumulates in a prion-like manner. To detect presence these α-syn aggregates clinical samples, seed amplification assays (SAAs) have been developed. These SAAs capable amplifying seeds, allowing for their detection. αSyn-SAAs reported under names 'protein cyclic amplification' (αSyn-PMCA) 'real-time quaking-induced conversion'α-Syn-RT-QuIC. The α-Syn RT-QuIC,...
Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, optimal radiotherapy regimen, particularly in terms of total dose and planned range irradiation field, remains unclear. This phase III clinical trial aimed to compare survival benefits between different radiation doses target fields.
To analyze the clinical and dosimetric risk factors of acute esophagitis (AE) in non-small-cell lung cancer (NSCLC) patients treated with concomitant chemoradiotherapy.Seventy-six NSCLC chemoradiotherapy were retrospectively analyzed. Forty-one received vinorelbine/cisplatin (VC), 35 docetaxel/cisplatin (DC). AE was graded according to criteria Radiation Therapy Oncology Group (RTOG). The following parameters analyzed: gender, age, stage, Karnofsky performance status (KPS), pretreatment...
Background: Parkinson's disease (PD) is a common, age-related, and progressive neurodegenerative disease. Growing evidence indicates that immune dysfunction plays an essential role in the pathogenic process of PD. The objective this study was to explore potential immune-related hub genes infiltration patterns Method: microarray expression data human postmortem substantia nigra samples were downloaded from GSE7621, GSE20141, GSE49036. Key module screened via weighted gene coexpression network...
Abstract A comprehensive manipulation of the Jones matrix phase channels is crucial for enhancing information capacity and security metasurface. However, a single‐layer planar metasurface, without incorporation chirality, can only achieve maximum three independent single under either linear or circular polarization bases. Here, an effective strategy proposed that utilizes dual matrices in different bases with monoatomic thus extending number to six. To encode six holographic images into...
<title>Abstract</title> Although immune checkpoint blockade (ICB) therapies have shown clinical benefit, ICB remains limited effect on most “immune-cold” solid tumors, i.e., tumors with low infiltration. Near-infrared photoimmunotherapy (NIR-PIT) converts “cold” into “hot” thereby enhancing responses and improving efficacy. Hence, developing a strategy that can integrate NIR-PIT treatment is desirable. In this study, we designed unique carrier-free PSP@IR-CF<sub>3</sub> nanofiber (NF),...
This study investigated whether conformal radiotherapy affects hepatitis B virus (HBV) reactivation, and the risk factors for HBV reactivation in patients with HBV-related hepatocellular carcinoma (HCC). Sixty-nine HCC were included this retrospective study. Before (RT), all underwent imaging examinations some baseline examinations, including CBC, liver function test, renal α-fetoprotein level, (HB) surface antigen, HB Ab, e serum DNA quantification. During period of RT at least 16 weeks...
Abstract Elongation factor Tu GTP binding domain containing 2 (EFTUD2), a spliceosomal GTPase, plays pivotal role in multiple organ development and innate immune. It has been reported that EFTUD2 is new host with activity against HCV infection. However, the of solid tumors, including hepatocellular carcinoma (HCC), remains unexplored. In this study, we investigated molecular function HCC. Data from The Cancer Genome Atlas (TCGA) indicated an upregulation HCC tissues compared to nontumor...
8014 Background: The phase 3 trial (CAPSTONE-1) showed that adebrelimab (PD-L1 antibody) combined with first-line chemotherapy could prolong overall survival (OS) in patients (pts) extensive-stage small cell lung cancer (ES-SCLC). Previous studies have shown radiotherapy can enhance the immunogenicity of tumors, indicating great potential combining immunotherapy. purpose this study was to explore efficacy and safety sequential thoracic (TRT) as therapy for ES-SCLC. Methods: Key inclusion...
Herein we design a therapeutic nanoplatform as carriers of oncogene siRNA and chemotherapeutics to achieve precise cancer therapy.
This paper established the random forest and Bayesian classification prediction models aims to find out risk factors of Hepatitis B virus (HBV) reactivation after precise radiotherapy in patients with primary liver cancer (PLC). Using identified we can provide reference doctor reduce incidence disease. Firstly, proposed method select key features then establish subset. All are sorted according importance. We 5 most important which would be combined into a brand new feature subset model. that...
Background: There is no standard management for small cell esophageal carcinoma (SCEC). The purpose of this multicenter, retrospective study (ChiSCER) was to investigate the treatment, outcomes, and risk factors impacting survival endpoints in patients with limited-stage SCEC (LS-SCEC). Materials Methods: Consecutive LS-SCEC from 14 institutions between 2000 2020 China were enrolled. Survival curves constructed using Kaplan–Meier method compared a log-rank test. Univariate multivariate Cox...
Parkinson's disease (PD) is a common neurodegenerative with rapid increase in incidence recent years. Existing treatments cannot slow or stop the progression of PD. It was proposed that neuroinflammation leads to neuronal death, making targeting promising therapeutic strategy. Our previous studies have demonstrated rhein protects neurons
Objectives Concurrent chemoradiotherapy in well-selected locally advanced non-small cell lung cancer (LANSCLC) is considered as standard therapy. However, the choice of anticancer agents still unresolved. Our objectives were to determine maximum tolerated dose and recommended pemetrexed combination with cisplatin, concurrent late course accelerated hyperfractionated (LCAF) intensity modulated radiotherapy (IMRT) patients LANSCLC investigate safety efficacy. Methods The chemotherapy was...
The aim is to investigate the feasibility of shrinking field technique after 40 Gy for stage III non-small cell lung cancer (NSCLC) during radiation therapy. Eighty-seven consecutive patients treated with intensity-modulated therapy or three-dimensional conformal were enrolled in this study. 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) scanning was performed prior treatment and repeated Gy, delineation target volume based on fused images PET CT....
The aim of the present study was to evaluate effect 3-dimensional conformal thoracic radiotherapy (TRT) on extensive-stage small-cell lung cancer (ES-SCLC). A total 165 patients with ES-SCLC were enrolled in study, including 82 receiving chemotherapy combined TRT (the ChT/TRT group) and 83 alone ChT group). overall survival (OS) progression-free (PFS) rates compared between groups, prognostic factors for OS rate identified. It found that had a median time 15 months, 2- 5-year 31.5 2.4%,...
The increasing panel of systemic therapies enables the individual management lung cancer patients, even in advanced stages. However, predictive tools indicating efficacy chemoradiotherapy (CRT) are badly needed. To determine tumour markers for predicting therapeutic effect non-small-cell carcinoma (NSCLC) patients treated with CRT. serum levels cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), neurone-specific enolase (NSE) and carcinoembryonic (CEA) were measured before CRT by enzyme-linked...