A5066163165- Microbial Natural Products and Biosynthesis
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Synthetic Organic Chemistry Methods
- Social Media in Health Education
- Cell death mechanisms and regulation
- Marine Sponges and Natural Products
- Antimicrobial Peptides and Activities
- Advanced Proteomics Techniques and Applications
- Chemical Synthesis and Analysis
- Health Literacy and Information Accessibility
- Natural product bioactivities and synthesis
- Misinformation and Its Impacts
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- HIV, Drug Use, Sexual Risk
University of Nottingham Ningbo China
2025
Shandong Institute of Automation
2025
Chinese Academy of Sciences
2010-2025
Dalian Institute of Chemical Physics
2019-2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2019-2025
Harbin Medical University
2024
University of Electronic Science and Technology of China
2024
Guangdong Medical College
2019-2023
Guangzhou Medical University
2023
First Hospital of China Medical University
2022-2023
Abstract Ferroptosis, a novel form of nonapoptotic cell death, can effectively enhance photodynamic therapy (PDT) performance by disrupting intracellular redox homeostasis and promoting apoptosis. However, the extremely hypoxic tumor microenvironment (TME) together with highly expressed hypoxia‐inducible factor‐1α (HIF‐1α) presents considerable challenge for clinical PDT against osteosarcoma (OS). Hence, an innovative nanoplatform that enhances antitumor inducing ferroptosis alleviating...
Previous studies establish guanylate binding protein 5 (GBP5) as a driver in the development of inflammatory bowel diseases (IBDs). Here, we aim to elucidate mechanism underlying pro-inflammatory role GBP5. We observe that loss Gbp5 causes reduced colonic inflammation and decreased numbers innate lymphoid cells (ILCs) colitis mice. The transcriptional alterations observed GBP5-deficient THP-1 mirrored those triggered by STAT1 activation, leading findings GBP5 is essential for stimulated...
Background: Beta-blockers are antihypertensive drugs and have shown potential in cancer prognosis. However, this benefit has not been well defined due to inconsistent results from the published studies. Methods: To investigate association between administration of beta-blocker prognosis, we performed a meta-analysis. A literature search PubMed, Embase, Cochrane Library, Web Science was conducted identify all relevant studies up September 1, 2017. Thirty-six involving 319,006 patients were...
Methylation of lysine residues on histone proteins is known to play an important role in chromatin structure and function. However, non-histone protein substrates this modification remain largely unknown. An effective approach for system-wide analysis methylation, particularly monomethylation, lacking. Here we describe a chemical proteomics global screening monomethyllysine substrates, involving propionylation monomethylated lysine, affinity enrichment the modified peptides, HPLC/MS/MS...
To investigate the current use status of official WeChat accounts for Centers Disease Control and Prevention in public health education relevant factors that can impact effectiveness message delivery.A retrospective survey was conducted to evaluate accounts. About 531 50 939 articles were analyzed using a cluster sampling design. The Kruskal-Wallis test multivariate logistic regression used explore associated with usefulness number views "Likes" articles.The study identified total accounts,...
Aberrant activations of the STAT3 (signal transducer and activator transcription 3) signaling pathway are associated with cancer inflammatory diseases. Three four Janus kinases, JAK1, JAK2, Tyk2, major upstream kinases in responses to cytokine stimulations. Among them, JAK2 is key kinase IL-6-induced phosphorylation. Here we report mechanisms a natural compound parthenolide from medicinal herb Feverfew regulating JAK/STAT3 signaling. We found that was potent inhibitor JAKs. It covalently...
Dynamic miRNA alteration is known to occur in colitis-associated colon cancer (CAC), while the molecular mechanisms underpinning how miRNAs modulate development from chronic inflammation CAC lacking. For first time, we constructed knockout (KO) mice for individual miR-148/152 family members and entire family. Based on these KO mice, conduct comprehensive analysis of family, demonstrating that deficiency any member aggravate colitis CAC. Loss or full-family enhance MMP10 MMP13 expression,...
Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to drainage lymph nodes, facilitating the development of lymphatic metastasis (LM). However, mechanisms governing tumor lymphangiogenesis and permeability gastric (GC) remain largely unknown. Here, unprecedented role mechanism cysteine-rich intestinal protein-1 (CRIP1) mediating GC LM is uncovered. A series assays are performed identify downstream targets CRIP1, rescue experiments confirm effects this regulatory...
Seven new benzoxazole derivatives, nocarbenzoxazoles A–G (1–7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures elucidated on basis of 1D and 2D NMR spectroscopic data, HRESIMS, X-ray single-crystal diffraction. The compounds assayed for their cytotoxicity against a panel human tumor cell lines (HepG2, MDA-MB-231, MDA-MB-435, HeLa, PC3). Compounds 1–6 found to have modest or no activity. Compound 7 showed selective activity HepG2 HeLa with IC50...
Aspergillus versicolor Y10 is an endophytic fungus isolated from Huperzia serrata, which showed inhibitory activity against acetylcholinesterase. An investigation of the chemical constituents led to isolation four new prenylated asteltoxin derivatives, named avertoxins A–D (2–5), together with known mycotoxin (1). In present study, we report structure elucidation for 2–5 and revised NMR assignments demonstrated that avertoxin B (3) active inhibitor human acetylcholinesterase IC50 value 14.9...
Propionylation at protein lysine residue is characterized to be present in both eukaryotic and prokaryotic species. However, the majority of propionylation substrates still remain largely unknown. Using affinity enrichment mass-spectrometric-based proteomics, we identified 1467 sites 603 proteins E. coli. Quantitative propionylome analysis further revealed that global level was drastically increased response propionate treatment, a carbon source for many microorganisms also common food...
Novel strains of influenza A viruses ( IAV s) have emerged with high infectivity and/or pathogenicity in recent years, causing worldwide concern. T cells are correlated protection humans through cross‐reactive immunity against heterosubtypes . However, the different hierarchical roles ‐derived epitopes distinct levels polymorphism ‐cell responses remain elusive. In this study, immunodominant scattered throughout entire proteome 2009 pandemic H1N1 virus and seasonal s were synthesized divided...
Social media is currently becoming a new channel for information acquisition and exchange. In China, with the growing popularity of WeChat official accounts (WOAs), health promotion agencies have an opportunity to use them successful distribution diffusion online.We aimed identify features articles pushed by WOAs Chinese provincial Centers Disease Control Prevention (CDC) that are associated user engagement.We searched subscribed 28 CDCs. Data this study consisted on these between January 1,...
<title>Abstract</title> Although immune checkpoint blockade (ICB) therapies have shown clinical benefit, ICB remains limited effect on most “immune-cold” solid tumors, i.e., tumors with low infiltration. Near-infrared photoimmunotherapy (NIR-PIT) converts “cold” into “hot” thereby enhancing responses and improving efficacy. Hence, developing a strategy that can integrate NIR-PIT treatment is desirable. In this study, we designed unique carrier-free PSP@IR-CF<sub>3</sub> nanofiber (NF),...
Abstract In this paper, bridge image data are collected using a UAV, and the images denoised enhanced wavelet analysis methods nonlinear variations. A deep convolutional neural network (DCNN) is used to construct model for reconstruction task of acquired reduce impact blurring other problems generated in process compression on damage identification. An improved with step-by-step input capability proposed, after feature extraction by MobileNet-v2 lightweight through separable convolution...
Methylation of lysine and arginine (K R) has emerged as a prevalent post-translational modification with critical roles in numerous biological processes. The current identification approaches suffer from suboptimal enrichment efficiency, particularly for methylation, hindering comprehensive KR methylome profiling. Herein, we presented an antibody-free strategy termed Selective Release Methylated Sites Immobilized Tryptic Peptides (SRMs-ITP), which achieves high efficiency while enabling the...