A5083405314- Liver Disease Diagnosis and Treatment
- Phytochemical Studies and Bioactivities
- Neuroendocrine Tumor Research Advances
- Natural product bioactivities and synthesis
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Chromatography in Natural Products
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- Alcohol Consumption and Health Effects
- Cancer-related gene regulation
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Nutrition, Genetics, and Disease
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Heart Rate Variability and Autonomic Control
Sun Yat-sen University
2012-2025
Huazhong University of Science and Technology
2016-2025
North China University of Science and Technology
2015-2025
Shandong University
2022-2025
Fudan University
2015-2025
Zhongshan Hospital
2015-2025
Capital Medical University
1996-2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2025
Shanxi Fenyang Hospital
2025
Harbin Medical University
2009-2025
Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental detection associated with prolonged survival, but screening asymptomatic individuals for PDAC using a single test remains unfeasible due to low prevalence potential harms of false positives. Non-contrast computed tomography (CT), routinely performed clinical indications, offers large-scale screening, however, identification non-contrast CT has...
Objective: This study aimed to investigate the interaction between age groups and risk factors for diabetes prediabetes in Shanghai communities identify effect of on other prediabetes. Methods: recruited 3540 participants with undiagnosed or 14 from February August 2019. All underwent a comprehensive examination, including filling out detailed questionnaire, physical 75 g oral glucose tolerance test, blood sample collection. In addition, logistic regression was used analyze diabetes....
The mechanism of podocyte apoptosis is not fully understood. In addition, the role inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) regulation axis, which located at sites endoplasmic reticulum (ER) mitochondria coupling, in unclear. This study aimed to understand roles this axis and explore potential targets for protection. expression IP3R, Grp75, VDAC1, MCU mitochondrial Ca2+...
Background and Purpose Dioscin exhibits a range of pharmacological actions but little is known its effects on cisplatin (CDDP)‐induced nephrotoxicity. Here, we have assessed the possible mechanisms dioscin against CDDP‐induced Experimental Approach We used an in vivo model nephrotoxicity rats mice and, vitro, cultures NRK‐52E HK‐2 cells. The dual luciferase reporter assay was to demonstrate modulation, by dioscin, targeting sirtuin 1 (Sirt1) microRNA (miR)‐34a. Molecular docking assays were...
Salvianolic acid B (SalB) is effective for treating cardiovascular diseases. However, the molecular mechanisms underlying its therapeutic effects remain unclear. Mechanosensitive Piezo1 channels play important roles in vascular biology, although their pharmacological properties are poorly defined. Here, we aimed to identify novel inhibitors and gain insights into of action.Intracellular Ca2+ ions were measured HUVECs, murine liver endothelial cells (MLECs), THP-1 RAW264.7 cell lines bone...
Kidney fibrosis is a common fate of chronic kidney diseases (CKDs), eventually leading to renal dysfunction. Yet, no effective treatment for this pathological process has been achieved. During the bioassay-guided chemical investigation medicinal plant Wikstroemia chamaedaphne, daphne diterpenoid, daphnepedunin A (DA), characterized as promising anti-renal fibrotic lead. DA shows significant anti-kidney effects in cultured fibroblasts and unilateral ureteral obstructed mice, being more potent...
Enhancing sensitivity to sorafenib can significantly extend the duration of resistance it, offering substantial benefits for treating patients with hepatocellular carcinoma (HCC). However, role ferroptosis in influencing within HCC remains pivotal. The enhancer zeste homolog 2 (EZH2) plays a significant promoting malignant progression HCC, yet relationship between ferroptosis, sensitivity, and EZH2 is not entirely clear. Bioinformatic analysis indicates elevated expression predicting an...
Abstract Background Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with the high mortality twofold to sixfold higher than that for ischemic stroke. But treatment haematomas within basal ganglia continues be matter debate among neurologists and neurosurgeons. The purpose this study judge short-term long-term clinical value minimally invasive stereotactic puncture therapy (MISPT) on acute ICH. Methods A prospective controlled was undertaken. trial in compliance WMA...
Abstract We previously reported the promising effects of dioscin against liver injury, but its effect on fibrosis remains unknown. The present work investigated activities and underlying molecular mechanisms. Dioscin effectively inhibited cell viabilities HSC-T6, LX-2 primary rat hepatic stellate cells (HSCs), not hepatocytes. Furthermore, markedly increased peroxisome proliferator activated receptor-γ (PPAR-γ) expression significantly reduced a-smooth muscle actin (α-SMA), transforming...
Dioscin shows potent effects against liver damage in our previous studies; however, the action of it on hepatic ischemia-reperfusion (I/R) injury is still unknown. In present article, and possible mechanisms dioscin I/R were investigated.Seventy percent partial warm ischemia was induced Wistar rats for 60 min followed by succedent reperfusion. prophylactic test, administered intragastrically to at doses 20, 40, mg/kg once daily seven consecutive days before I/R. therapeutic received a dose 2...
The protective effects of dioscin, a natural steroidal saponin from some medicinal plants including Dioscorea nipponica Makino, against lipopolysaccharide (LPS)- induced acute liver and renal damages have been reported in our previous works. However, its effect on LPS-induced lung injury (ALI) remains unknown. In the present study, possible mechanisms dioscin ALI vitro vivo were investigated. results showed that effectively inhibited cell proliferation markedly decreased reactive oxidative...
Background The association between dyslipidemia, a major risk factor for cardiovascular diseases, and atrial fibrillation (AF) is not clear because of limited evidence. Hypothesis. Dyslipidemia may be associated with increased AF in Chinese population. Methods A total 88 785 participants free from at baseline (2006–2007) were identified the Kailuan Study. Fasting levels cholesterol (TC), low‐density lipoprotein (LDL‐C), high‐density (HDL‐C), triglycerides (TG) measured using standard...
Background and Purpose The aim of the present study was to investigate effects possible underlying mechanisms dioscin against pancreatic cancer in vitro vivo . Experimental Approach In actions on viability ASPC‐1 PANC‐1 cells, suppress tumour growth cell xenografts nude mice were assessed. addition, microRNA microarray analysis determined which microRNAs affected by dioscin. elucidated terms Akt1 other proteins related aopoptosis. Key Results Dioscin markedly induced apoptosis significantly...
The aim of this study is to examine the bidirectional association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM).The data was derived from Dongfeng-Tongji cohort study, which established in 2008 followed until October 2013. NAFLD classified as none, mild, moderate/severe based on ultrasound examination. analysis incident T2DM risk included 18,111 participants free at baseline duration follow-up 4.60 ± 0.60 years. Cox proportional regression model used...