A5100401079- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Hedgehog Signaling Pathway Studies
- Inflammasome and immune disorders
- Cancer Cells and Metastasis
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Birth, Development, and Health
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Heme Oxygenase-1 and Carbon Monoxide
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Cellular Mechanics and Interactions
- Cancer, Lipids, and Metabolism
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Xi'an Jiaotong University
2011-2025
Capital Medical University
2025
Shanghai Jiao Tong University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Tianjin Chest Hospital
2024
Tianjin University
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Shanghai Sixth People's Hospital
2024
Objective Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose at resectable stage. Recent studies have suggested that extracellular vesicles (EVs) contain long RNAs. The aim of this study was develop a diagnostic (d-)signature for the detection PDAC based on EV RNA (exLR) profiling. Design We conducted case-control with 501 participants, including 284 patients PDAC, 100 chronic pancreatitis (CP) and 117 healthy subjects. exLR profile plasma samples analysed by sequencing....
Ferroptosis is a new form of regulated cell death that mediated by intracellular iron and ester oxygenase, glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis converting hydroperoxides into nontoxic alcohols. Although thiostrepton (TST) has been reported to exert antitumor effects, its role in pancreatic cancer the underlying mechanisms remain unclear. In this study, we found TST reduced viability clonogenesis lines, along with overload,...
Male sterility is an essential trait in hybrid seed production for monoclinous crops, including rice and wheat. However, compared with the high percentage of planted world, little commercial wheat globally as a result lack suitable system male sterility. Therefore, understanding molecular nature fertility critical commercially viable Here, we report cloning characterization Sterility 1 (Ms1) bread by using combination advanced genomic approaches. MS1 newly evolved gene Poaceae that...
Diabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) an important transcription involved in both lipid metabolism and tumor progression. However, relationship between high glucose microenvironment, SREBP1 cancer remains explored.Clinical data surgical specimens were collected. Pancreatic cell lines BxPc-3 MiaPaCa-2 cultured specified medium. Immunohistochemistry (IHC) western...
Perineural invasion (PNI) and autophagy are two common features in the tumor microenvironment of pancreatic cancer (PanCa) have a negative effect on prognosis. Potential mediator cells molecular mechanism underlying their relationships need to be fully elucidated.To investigate Schwann (SCs) PNI, we reproduced PNI by collecting clinical tissue, performing sciatic nerve injection nude mice with establishing Dorsal root ganglion (DRG) coculture system cell lines. Autophagy was detected IHC,...
Abstract Perineural invasion (PNI) is a pathologic feature of pancreatic cancer and associated with poor outcomes, metastasis, recurrence in patients. However, the molecular mechanism PNI remains unclear. The present study aimed to investigate that HGF/c-Met pathway facilitates cancer. In this study, we confirmed c-Met expression was correlated tissues. Activating signaling potentiated nerve growth factor (NGF) recruit nerves promote PNI. also enhanced migration ability cells facilitate...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes association with perturbations of developmental cell signaling pathways have been associated PDAC development progression. Here, we show that GATA6 contributes to pancreatic carcinogenesis during the temporal progression intraepithelial neoplasia virtue Wnt pathway activation. recurrently amplified both quantitative-PCR...
Abstract Background Smoking and stress, pancreatic cancer (PanCa) risk factors, stimulate nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) catecholamines production respectively. NNK catecholamine bind the β-adrenoceptors induce PanCa cell proliferation; we have previously suggested that β-adrenergic antagonists may suppress proliferation invasion apoptosis in PanCa. To clarify mechanism of induced by β 2 -adrenergic antagonist, hypothesize blockage -adrenoceptor could G 1 /S...
Abstract Pancreatic cancer significantly affects the quality of life due to severe abdominal pain. However, underlying mechanism is not clear. This study aimed determine relationship between Substance P (SP) and pancreatic perineural invasion (PNI) as well SP mediating PNI, which causes pain in patients with cancer. Human cells newborn dorsal root ganglions (DRG) were used expression or NK-1R DRGs by QT-PCR Western blotting. The effects on cell proliferation analyzed using MTT assay...
α -Mangostin, a natural product isolated from the pericarp of mangosteen fruit, has been shown to inhibit growth tumor cells in various types cancers. However, underlying molecular mechanisms are largely unclear. Here, we report that -mangostin suppressed viability and epithelial-mesenchymal transition (EMT) pancreatic cancer through inhibition PI3K/Akt pathway. Treatment BxPc-3 Panc-1 with resulted loss cell viability, accompanied by enhanced apoptosis, cycle arrest at G1 phase, decrease...
// Jiguang Ma 1,* , Wanxing Duan Suxia Han 1 Jianjun Lei 2 Qinhong Xu Xin Chen Zhengdong Jiang Ligang Nan Jiahui Li Ke Liang Zheng Wang Xuqi 3 Erxi Wu 4 Xiongwei Huo Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China Hepatobiliary Surgery, General Pharmaceutical Sciences, North Dakota State Fargo, ND, USA * These authors have contributed equally to this work Correspondence to: Han, email: Huo, Keywords : lipogenesis, cancer metabolism, ginkgolic acid...
// Qinhong Xu 1 , Zheng Wang Xin Chen Wanxing Duan Jianjun Lei Liang Zong Xuqi Li 3 Sheng Jiguang Ma 2 Han Wei Lun Zhang Kun Guo Zhenhua Wu Erxi 4 and Qingyong Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College, Xi’an Jiaotong University, 710061, Shaanxi, China Oncology, General Pharmaceutical Sciences, North Dakota State Fargo, ND 58105, USA Correspondence: Ma, email: Wang, Keywords : CXCL12/CXCR4 axis, Perineural Invasion, Tumor Microenvironment,...
Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. MicroRNAs control gene expression by negatively regulating protein‐coding mRNAs. Several reports demonstrated that miR‐106a up‐regulated in gastric colorectal cancers promotes tumor progression. In contrast, glioma plays the role of suppressor rather than an oncogene. Here we demonstrate high level present pancreatic cancer. Furthermore, our investigation shows has oncogenic tumorigenesis...
Hippo/YAP pathway is known to be important for development, growth and organogenesis, dysregulation of this leads tumor progression. We others find that YAP up-regulated in pancreatic ductal adenocarcinoma (PDAC) associated with worse prognosis patients. Activated stellate cells (PSCs) forming the components microenvironment enhance cancer (PCs) invasiveness malignance. However, role mechanism PDAC tumor-stromal interaction largely unknown.The expression Pancreatic cell lines samples was...
Resveratrol, a natural polyphenol present in most plants, inhibits the growth of numerous cancers both vitro and vivo. Aberrant expression YAP has been reported to activate multiple growth-regulatory pathways confer anti-apoptotic abilities many cancer cells. However, role resveratrol YES-activated protein (YAP) that pancreatic cells’ response gemcitabine resistance remain elusive. In this study, we found suppressed proliferation cloning ability induced apoptosis These biological effects...
Microenvironment plays a vital role in tumor progression; we focused on elucidating the of hepatic stellate cells (HSCs) hepatocarcinoma (HCC) aggressiveness and investigated potential protective effect curcumin HSC-driven angiogenesis invasion. Our data suggest that HSCs increase HCC reactive oxygen species (ROS) production to upregulate hypoxia-inducible factor-1 α (HIF-1 ) expression promote angiogenesis, epithelial mesenchymal transition (EMT) process And could secrete soluble factors,...
Abstract During mesenchymal development, the sources of mechanical forces transduced by cells transition over time from predominantly cell-cell interactions to cell-extracellular matrix (ECM) interactions. Transduction associated signals is critical for but how these converge regulate human stem (hMSCs) mechanosensing not fully understood, in part because time-evolving cannot readily be presented vitro. Here, we established a DNA-driven cell culture platform that could programmed present RGD...
Background/Aims: Sulforaphane (SFN) is known for its potent bioactive properties, such as anti-inflammatory and anti-tumor effects. However, effect on pancreatic cancer still poorly understood. In the present study, we explored therapeutic potential of SFN disclosed underlying mechanism. Methods: Panc-1 MiaPaca-2 cell lines were used in vitro. The biological function was measured using EdU staining, colony formation, apoptosis, migration invasion assays. Reactive oxygen species (ROS)...