A5051440995- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Platelet Disorders and Treatments
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Retinal Diseases and Treatments
- NF-κB Signaling Pathways
- Gut microbiota and health
- Retinal Imaging and Analysis
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Adrenal and Paraganglionic Tumors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Central South University
2016-2025
University of California, Berkeley
2019-2025
Second Xiangya Hospital of Central South University
2014-2025
First People's Hospital of Jingzhou
2025
Shenzhen Second People's Hospital
2021-2025
Heidelberg University
2021-2025
University Hospital Heidelberg
2022-2025
Tsinghua University
2025
Yangtze University
2024
University of Chinese Academy of Social Sciences
2021-2024
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that cytosolic lncRNA P53RRA is downregulated cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH Cfp1 silenced or increased expression, respectively. bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 871 RRM interaction domain G3BP1...
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal oxygen tension, HIF-1 activity usually suppressed due to the rapid, oxygen-dependent degradation of one its two subunits, HIF-1α. Here we report that normoxic can be upregulated through NO-mediated S-nitrosylation and stabilization In murine tumors, exposure ionizing radiation stimulated generation NO in tumor-associated macrophages. As result, HIF-1α protein S-nitrosylated at Cys533 (through "biotin switch"...
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases.However, the epigenetic mechanisms underlying ferroptosis remain poorly defined.First, we demonstrated that lymphoid-specific helicase (LSH), which DNA methylation modifier, interacted with WDR76 to inhibit by activating lipid metabolism-associated genes, including GLUT1, and related genes SCD1 FADS2, turn, involved Warburg effect.WDR76 targeted these expression dependent manner LSH chromatin...
In this study, a magnetothermodynamic (MTD) therapy is introduced as an efficient systemic cancer treatment, by combining the magnetothermal effect and reactive oxygen species (ROS)-related immunologic effect, in order to overcome obstacle of limited therapeutic efficacy current (MTT). This approach was achieved development elaborate ferrimagnetic vortex-domain iron oxide nanoring graphene (FVIOs-GO) hybrid nanoparticle MTD agent. Such FVIOs-GO nanoplatform shown have high thermal conversion...
Seed microbiome includes special endophytic or epiphytic microbial taxa associated with seeds, which affects seed germination, plant growth, and health. Here, we analyzed the core of 21 Salvia miltiorrhiza seeds from seven different geographic origins using 16S rDNA ITS amplicon sequencing, followed by bioinformatics analysis. The whole bacterial was classified into 17 phyla 39 classes. Gammaproteobacteria (67.6%), Alphaproteobacteria (15.6%), Betaproteobacteria (2.6%), Sphingobacteria...
Neutrophils are known to have antitumor potential. However, in recent years the tumor-promoting effect of neutrophils has been well demonstrated. So far, it remains unclear what causes conversion neutrophil function from tumor suppressive promoting. In this article, we report that murine occurs bone marrow, and IL-6 cooperation with G-CSF is required for conversion. cooperated modulate altering activation potential signaling pathways neutrophils, especially STAT3. Costimulation induced a...
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed cancer preventive and therapeutic effects metformin, one most widely prescribed medications for type 2 diabetes mellitus. However, its role in pancreatic not fully elucidated. Herein, we aimed to further study metformin genetically engineered mouse models cancer. LSL-KrasG12D/+; Pdx1-Cre (KC)...
The changes of gastric microbiome across stages neoplastic progression remain poorly understood, especially for intraepithelial neoplasia (IN) which has been reorganized as a phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. microbiota was investigated in 30 healthy controls (HC), 21 non-atrophic chronic gastritis (CG), 27 intestinal metaplasia (IM), 25 IN 29 cancer (GC) patients by 16S rRNA gene profiling. bacterial diversity, abundances phyla Armatimonadetes,...
Abstract Chromatin modification is pivotal to the epithelial–mesenchymal transition (EMT), which confers potent metastatic potential cancer cells. Here, we report a role for chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), prevalent China. LSH expression was increased NPC, where it controlled by Epstein–Barr virus-encoded protein LMP1. In NPC cells vitro and vivo, promoted progression part regulating of fumarate hydratase (FH), core component...
Background: Bladder cancer is the fourth and tenth most common malignancy in men women worldwide, respectively.One of main reasons for unsatisfactory therapeutic control bladder that molecular biological mechanism complex.Gasdermin B (GSDMB) one member gasdermin family participates regulation cell pyroptosis.The role GSDMB has not been studied to date.Methods: TCGA database was used exam clinical relevance GSDMB.Functional assays such as MTT assay, Celigo fluorescent cell-counting Annexin...
Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs. However, its clinical use has been hampered due to development cardiotoxicity. Vitexin, which active ingredient hawthorn leaf extract, various biological activities, including antioxidant and anti-inflammatory actions. The present study aimed investigate whether vitexin was able protect against DOX-induced acute cardiotoxicity in model rats mechanisms this protective effect were assessed. Adult Sprague-Dawley randomly...
Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy to treat many degenerative diseases. Accumulating evidence shows that the function of MSCs declines with age, thus limiting their regenerative capacity. Nonetheless, underlying mechanisms control MSC ageing are not well understood. We show compared bone marrow-MSCs (BM-MSCs) isolated from young and aged samples, NADH dehydrogenase (ubiquinone) iron-sulfur protein 6 (Ndufs6) is depressed in MSCs. Similar Ndufs6 knockout...
Osteoarthritis (OA), the most common form of arthritis, is a very joint disease that often affects middle-aged to elderly people. However, current treatment options for OA are predominantly palliative. Thus, understanding its pathological process and exploring potential therapeutic approaches great importance. Rat chondrocytes were isolated exposed hydrogen peroxide (H 2 O ) mimic OA. The effects H on ubiquitin-specific protease 7 (USP7) expression, reactive oxygen species (ROS) levels,...
To characterize the salivary microbiota in patients at different progressive histological stages of gastric carcinogenesis and identify microbial markers for detecting cancer, two hundred ninety-three were grouped into superficial gastritis (SG; n = 101), atrophic (AG; 93), cancer (GC; 99) according to their histology. 16S rRNA gene sequencing was used access profile. A random forest model constructed classify types based on compositions. distinct observed with GC when comparing SG AG, which...
Abstract Background Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. This study aimed to develop and evaluate an OCT-omics prediction model for assessing anti-vascular endothelial growth factor (VEGF) treatment response DME. Methods A retrospective analysis 113 eyes from 82 DME was conducted. Comprehensive feature engineering applied clinical optical coherence tomography (OCT) data. Logistic regression, support vector machine (SVM), backpropagation...
Abstract Tumor necrosis factor-α (TNF-α) is an important inflammation cytokine without known direct effect on DNA. In this study, we found that TNF-α can cause DNA damages through reactive oxygen species. The mutagenic of comparable with ionizing radiation. treatment in cultured cells resulted increased gene mutations, amplification, micronuclei formation, and chromosomal instability. Antioxidants significantly reduced TNF-α–induced genetic damage. also induced oxidative stress nucleotide...
Kaposi's sarcoma (KS) is the major AIDS-associated malignancy. It characterized by proliferation of spindle cells, inflammatory infiltrate, and aberrant angiogenesis caused herpesvirus (KSHV) infection. Small GTPase Rac1, an signaling mediator triggering reactive oxygen species (ROS) production NADPH-oxidases, implicated in carcinogenesis tumor angiogenesis. Here, we show that expression a constitutively active Rac1 (RacCA) driven α-smooth muscle actin promoter transgenic mice sufficient to...
NAF-1 (nutrient-deprivation autophagy factor-1), which is an outer mitochondrial membrane protein, known to play important roles in calcium metabolism, antiapoptosis, and antiautophagy. Resveratrol, a natural polyphenolic compound, considered as potent anticancer agent. Nevertheless, the molecular mechanisms underlying effects of resveratrol their mediation drug resistance pancreatic cancer remain unclear. Here, we demonstrate that suppresses expression cells by inducing cellular reactive...
Gemcitabine is a standard treatment for advanced pancreatic cancer patients but can cause chemoresistance during treatment. The chemoresistant cells have features of stem (CSCs). Resveratrol has been reported to overcome the resistance induced by gemcitabine. However, mechanism which resveratrol enhances chemosensitivity remains elusive. Here, we explored enhanced and role sterol regulatory element binding protein 1 (SREBP1) in gemcitabine-induced stemness.The cell lines MiaPaCa-2 Panc-1...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with mortality rate that closely parallels its incidence rate, and better understanding of the molecular cellular mechanisms associated invasion distant metastasis required. Heat shock factor 1 (HSF1) very highly conserved in eukaryotes regulates protective heat response. Here, we show HSF1 abnormally activated pancreatic cancer. The knockdown impaired migration epithelial-mesenchymal transition (EMT) cancer cells vitro; however,...
MicroRNAs (miRNAs) present frequently altered expression in urologic cancers including prostate, bladder, and kidney cancer. The of miR-223 has been reported other diseases recent researches. MiR-223 is up-regulated systemic lupus erythematosus rheumatoid arthritis. In neoplastic diseases, proved to be up-expressed plasma or serum cancer tissues compared with normal pancreatic cancer, gastric et al. However, whether associated prostate (PCa) what it potential functions PCa remained unveiled....