A5054230534- Ocular Surface and Contact Lens
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Retinal Diseases and Treatments
- Salivary Gland Disorders and Functions
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Contact Dermatitis and Allergies
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Connexins and lens biology
- Allergic Rhinitis and Sensitization
- Glaucoma and retinal disorders
- melanin and skin pigmentation
Second Xiangya Hospital of Central South University
2022-2025
Central South University
2022-2025
Hunan Provincial Center for Disease Control and Prevention
2022-2025
Abstract Background Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. This study aimed to develop and evaluate an OCT-omics prediction model for assessing anti-vascular endothelial growth factor (VEGF) treatment response DME. Methods A retrospective analysis 113 eyes from 82 DME was conducted. Comprehensive feature engineering applied clinical optical coherence tomography (OCT) data. Logistic regression, support vector machine (SVM), backpropagation...
To explore the relationship among ocular surface changes, systemic hematologic indexes, and disease activity in primary Sjögren's syndrome patients. Thirty-three patients 36 healthy controls were recruited this cross-sectional study. All participants underwent complete testing, including dry eye symptoms signs, tear multi-cytokine analysis, conjunctival impression cytology (CIC). Multiple indexes also evaluated, autoantibodies, immune cells, EULAR Syndrome Patient Reported Index (ESSPRI),...
Diabetic retinopathy (DR) is an important microvascular complication of type 1 and 2 diabetes mellitus (DM) a major cause blindness. Retinal neovascularization plays critical role in the proliferative DR. In this study, high glucose-induced connexin 43 (Cx43) expression human retinal endothelial cells (hRECs) dose-dependent manner. Compared with hRECs under normal culture conditions, high-glucose (HG)-stimulated showed promoted tubule formation, increased ROS release, elevated levels tumor...
Abstract Objective This cross-sectional study aimed to reveal the association between ocular surface disorders and psychological, physiological situations among autoimmune rheumatic patients. Methods Ninety patients (180 eyes) hospitalized in Department of Rheumatology, The Second Xiangya Hospital, Central South University 30 controls (60 were enrolled study. All participants assessed for including dry eye disease (DED) by Ocular Surface Disease Index (OSDI) symptoms evaluation, slim lamp...
Purpose To evaluate dry eye severity and ocular surface inflammation in autoimmune rheumatic diseases (ARDs).
The cross-sectional study was designed to evaluate the association of ocular surface inflammation with systemic conditions in patients lupus erythematosus (SLE).
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare extremely serious drug-induced dermatological disorders. The ocular surface condition at the early stage has been little studied should contribute to novel perspectives in effective topical therapy of these diseases. objectives study were evaluate acute phase involvement histopathologic changes patients with SJS/TEN.Ten SJS/TEN onset eleven age- sex-matched healthy volunteers recruited. Ocular symptoms signs,...
Purpose To evaluate ocular surface involvement, tear cytokine levels, and histopathological changes in pemphigus pemphigoid patients.Methods A total of 22 patients (15 7 pemphigoids) 21 non-diseased controls were enrolled our study. All participants underwent evaluation, which included disease index test, slit lamp observation, dry eye-related examination, multicytokine analysis, conjunctival impression cytology.Results Pemphigus presented much more severe conjunctivochalasis, corneal...
Autoimmune blistering skin diseases (AIBD) are a group of rare chronic autoimmune which associated with ocular surface especially dry eye disease. This study is designed to investigate the relationship between disorders and quality life among patients diseases.Twenty-four AIBD (18 pemphigus 7 pemphigoid) twenty-five non-AIBD controls were included. Ocular disease index (OSDI), evaluation, including slit-lamp examination, Schirmer I test, tear break-up time, corneal fluorescein staining,...
Abstract Purpose: To evaluate and explore the ocular surface involvement systemic conditions in autoimmune rheumatic diseases (ARDs). Methods: 79 patients with ARDs were enrolled our study, including 26 rheumatoid arthritis (RA), 33 lupus erythematosus (SLE), 20 primary Sjögren’s syndrome (pSS). All underwent evaluation, symptoms signs, conjunctival impression cytology, tear multi-cytokine detection. The also collected, disease duration activity. Results: SLE have shortest nearly half of...
Abstract Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare extremely serious drug-induced dermatological disorders. The ocular surface condition at the early stage has been little studied should contribute to novel perspectives in effective topical therapy of these diseases. objectives study were evaluate acute phase involvement histopathologic changes patients with SJS/TEN. Methods Ten SJS/TEN onset eleven age- sex-matched healthy volunteers recruited....