A5100727180- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Animal Nutrition and Physiology
- RNA Research and Splicing
- Circular RNAs in diseases
- Avian ecology and behavior
- Cancer, Lipids, and Metabolism
- Genomics and Chromatin Dynamics
- Digestive system and related health
- Liver Disease Diagnosis and Treatment
- Insect-Plant Interactions and Control
- Cancer Immunotherapy and Biomarkers
- Drug-Induced Hepatotoxicity and Protection
- melanin and skin pigmentation
- Vector-borne infectious diseases
- Plant Virus Research Studies
- Gut microbiota and health
- Genetics and Neurodevelopmental Disorders
- Ovarian function and disorders
- Ubiquitin and proteasome pathways
- Phytochemistry and Biological Activities
University of Chinese Academy of Sciences
2022-2025
Institute of Subtropical Agriculture
2022-2025
Chinese Academy of Sciences
2022-2025
Lanzhou University
2018-2025
Lanzhou University Second Hospital
2018-2025
Central South University
2016-2025
Academy of Military Medical Sciences
2025
Beijing Forestry University
2023-2025
Second Xiangya Hospital of Central South University
2025
Hunan Provincial Center for Disease Control and Prevention
2025
The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a dynamic role in transcriptional translational regulation, is involved cancer. However, the circuitry lncRNAs tumorigenesis remains elusive. Here we demonstrate that nuclear lncRNA LINC00336 upregulated lung cancer functions as an oncogene by acting competing endogenous RNA (ceRNAs). bound RNA-binding protein ELAVL1 (ELAV-like 1) using nucleotides 1901–2107 of RRM interaction domain key amino acids (aa) (aa...
Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that cytosolic lncRNA P53RRA is downregulated cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH Cfp1 silenced or increased expression, respectively. bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 871 RRM interaction domain G3BP1...
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases.However, the epigenetic mechanisms underlying ferroptosis remain poorly defined.First, we demonstrated that lymphoid-specific helicase (LSH), which DNA methylation modifier, interacted with WDR76 to inhibit by activating lipid metabolism-associated genes, including GLUT1, and related genes SCD1 FADS2, turn, involved Warburg effect.WDR76 targeted these expression dependent manner LSH chromatin...
Ferroptosis is primarily caused by intracellular iron catalytic activity and lipid peroxidation. The potential interplay between ferroptosis apoptosis remains poorly understood. Here, we show that the expression of a nuclear long non-coding RNA (lncRNA), LINC00618, reduced in human leukemia strongly increased vincristine (VCR) treatment. Furthermore, LINC00618 promotes increasing levels BCL2-Associated X (BAX) cleavage caspase-3. also accelerates reactive oxygen species (ROS) iron, two...
Skin cutaneous melanoma (SKCM, hereafter referred to as melanoma) is the most lethal skin cancer with increasing incidence. Regulated cell death plays an important role in tumorigenesis and serves target for almost all treatment strategies. Cuproptosis recently identified copper-dependent regulated form that relies on mitochondria respiration. However, its remains unknown. The correlation of cuproptosis-related genes tumor prognosis far be understood, either. In present study, we explored...
Abstract Chromatin modification is pivotal to the epithelial–mesenchymal transition (EMT), which confers potent metastatic potential cancer cells. Here, we report a role for chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), prevalent China. LSH expression was increased NPC, where it controlled by Epstein–Barr virus-encoded protein LMP1. In NPC cells vitro and vivo, promoted progression part regulating of fumarate hydratase (FH), core component...
Background Tick-borne infectious diseases caused by the spotted fever group Rickettsia (SFGR) have continuously emerging, with many previously unidentified SFGR species reported. The prevalence of SFGRs in northwestern China remains unclear. This study aimed to examine and Anaplasma analyzing tick samples collected from Ningxia region. Methods During 2022–2023, ticks were Ningxia, China, screened using PCR amplify target genes (16S rRNA, gltA , ompA groEL ). amplicons confirmed Sanger...
Purpose: Graves' ophthalmopathy (GO), the most common extrathyroidal manifestation of disease, is disabling and disfiguring. Recent studies have shown that statins a protective effect on individuals with GO. Statins were reported to trigger ferroptosis in some disorders, but little known about whether protect against GO via ferroptosis. The aim this study was explore involved simvastatin Methods: GO-OFs, which are orbital fibroblasts (OFs) derived from GO, analyzed for lipogenesis by RT-qPCR...
Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in TIC self-renewal. However, molecular mechanism of initiation tumorigenesis TICs is still elusive. Here, we examined expression pattern 10 Wnt receptors (FZD1-FZD10), found only FZD6 overexpressed along with tumorigenesis. What's more, divergent lncRNA FZD6, termed lncFZD6, also highly...
Abstract Cancer stem cells (CSCs) exhibit highly aggressive and metastatic features resistance to chemotherapy radiotherapy. Aryl hydrocarbon receptor (AhR) expression varies among non-small cell lung cancers (NSCLCs), the mechanisms that support abnormal AhR in CSCs remain elusive. Here, we identified ubiquitin carboxyl terminal hydrolase L3 (UCHL3), a DUB enzyme UCH protease family, as bona fide deubiquitylase of NSCLC. UCHL3 was shown interact with, deubiquitylate, stabilize manner...
The signaling pathway-based stratification in chromatin modification could predict clinical outcome more reliably than morphology-alone-based classification schemes gliomas. Here we reported a role of the chromatin-remodeling factor lymphoid-specific helicase (LSH) Among astrocytomas grade I to III and glioblastoma IV, LSH were almost completely expressed all cases, strongly correlated with progression poor prognosis patients glioblastoma. Ectopic expression promoted tumor formation....
Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology treatment of cancer, regulation oncogene by chromatin at post-transcriptional level is critical remains unclear. We have investigated role GINS4 NSCLC.The expression modifier lymphoid-specific helicase (LSH) was assessed tumor normal tissue from 79 patients with NSCLC clinical characteristics. HBE, A549, H358, H522, PC9, 95C 95D were cultured after overexpression or silencing GIAT4RA....
Valine is an important essential amino acid of laying hens. Dietary supplemented with BCAAs ameliorated gut microbiota, whereas elevated blood levels are positively associated obesity, insulin resistance, and diabetes in both humans rodents. General controlled nonrepressed (GCN2) kinase plays a crucial role regulating intestinal inflammation hepatic fatty homeostasis during acids deficiency, while GCN2 deficient results enhanced developed steatosis. However, how long-term dietary valine...
Non-alcoholic fatty liver disease (NAFLD) is a chronic and metabolic commonly occurs in humans with obesity type 2 diabetes mellitus (T2DM); such condition also exists animals as rodents laying hens. Since the pathogenesis of hemorrhagic syndrome (FLHS) hens similar to human NAFLD, hen's FLHS selected study model NAFLD. Altered circulating amino acids, particularly elevated branched-chain acids (BCAAs) aromatic (AAAs), are consistently reported patients NAFLD T2DM. How long-term dietary...
Abstract Most cancer patients receive radiotherapy in the course of their disease and occurrence radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during development are poorly understood. Here, we demonstrate aryl hydrocarbon receptor (AhR) plays a vital role maintenance stem-like properties. AhR promotes phenotype drives metastasis by directly targeting promoters ‘stemness’ genes, such as ATP-binding cassette sub-family G...