A5101487042- Extracellular vesicles in disease
- Congenital heart defects research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Electrocatalysts for Energy Conversion
- Catalytic Processes in Materials Science
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Membrane Separation Technologies
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Beetle Biology and Toxicology Studies
- Congenital Heart Disease Studies
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Nanomaterials for catalytic reactions
- Catalysts for Methane Reforming
- Adsorption and biosorption for pollutant removal
- Speech Recognition and Synthesis
- Peroxisome Proliferator-Activated Receptors
- Membrane-based Ion Separation Techniques
Yancheng Institute of Technology
2023-2024
China Mobile (China)
2023
Shanghai Medical College of Fudan University
2018-2022
Fudan University Shanghai Cancer Center
2018-2022
Sino-Japan Friendship Center for Environmental Protection
2019-2020
St. Luke's Episcopal Hospital
2014-2015
Jiangsu Province Hospital
2013
Nanjing Medical University
2012-2013
China University of Petroleum, Beijing
2007
Iran University of Science and Technology
2007
Objective Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose at resectable stage. Recent studies have suggested that extracellular vesicles (EVs) contain long RNAs. The aim of this study was develop a diagnostic (d-)signature for the detection PDAC based on EV RNA (exLR) profiling. Design We conducted case-control with 501 participants, including 284 patients PDAC, 100 chronic pancreatitis (CP) and 117 healthy subjects. exLR profile plasma samples analysed by sequencing....
Oncolytic viruses mediate antitumor responses through direct tumor cell lysis and induction of host immunity. However, the therapeutic efficacy oncolytic against malignant ascites has rarely been explored. This study aimed to evaluate efficacy, safety, immunomodulatory effect an intraperitoneal injection human type 5 recombinant adenovirus (called H101) ascites. Forty patients with were recruited treated H101 in Fudan University Shanghai Cancer Center. The 4-week clinical determined by...
Ezh2 is a histone trimethyltransferase that silences genes mainly via catalyzing trimethylation of 3 lysine 27 (H3K27Me3). The role as regulator gene silencing and cell proliferation in cancer development has been extensively investigated; however, its function heart during embryonic cardiogenesis not well studied. In the present study, we used genetically modified mouse system which was specifically ablated heart. We identified wide spectrum cardiovascular malformations mutant mice,...
Fatty acid-binding protein 3 (FABP3) is a low-molecular-weight with distinct tissue distribution that may play an important role in fatty acid transport, cell growth, cellular signaling, and gene transcription. Previously, we have found FABP3 was involved apoptosis-associated congenital cardiac malformations, but the underlying mechanisms not yet been described. In present study, investigated characteristics of mitochondrial dysfunction embryonic cancer cells (P19 cells) overexpressed FABP3....
Mesoporous nanocrystalline zirconia with a high surface area and pure tetragonal crystallite phase has been prepared by the surfactant-assisted route, using Pluronic P123 block copolymer surfactant. The synthesized showed of 174 m2 g-1 after calcination at 700 °C for 4 h. X-ray diffraction nitrogen adsorption analysis that mesoporous structure were stable toward higher temperatures. was employed as support nickel catalysts production syngas dry reforming reaction. It shown 5% Ni/ZrO2...
Abstract Purpose: Oncogenic mutations in NRAS promote tumorigenesis. Although novel anti-NRAS inhibitors are urgently needed for the treatment of cancer, protein is generally considered “undruggable” and no effective therapies have yet reached clinic. STK19 kinase was recently reported to be a activator potential therapeutic target NRAS-mutant melanomas. Here, we describe new pharmacologic inhibitor cancers. Experimental Design: The identified from natural compound library using luminescent...
Long noncoding RNAs (lncRNAs) represent a sub-group of that are longer than 200 nucleotides. The characterization lncRNAs and their acceptance as crucial regulators numerous developmental biological pathways have suggested the lncRNA study has gradually become one hot topics in field RNA biology. Many show spatially temporally restricted expression patterns during embryogenesis organogenesis. This aimed to characterize profile fetal mouse heart at three key time points (embryonic day E11.5,...
Yin Yang 1 (YY1), the only DNA binding polycomb group protein, was reported to regulate cardiomyocyte differentiation during early cardiac mesoderm development. However, whether it contributes morphogenesis at later developmental stage(s) embryogenesis is unknown.We excised YY1 in murine hearts using two temporal-spatially controlled cre activation approaches, and revealed critical roles of structural formation. Alpha-myosin heavy chain-cre (α-MHC-cre)-mediated cardiomyocyte-specific...
Identification of clinically applicable molecular subtypes pancreatic ductal adenocarcinoma (PDAC) is crucial to improving patient outcomes. However, the traditional tissue-dependent transcriptional subtyping strategies are invasive and not amenable routine clinical evaluation. In this study, we developed a circulating extracellular vesicle (cEV) long RNA (exLR)-based PDAC method provided exLR-derived signatures for predicting immunogenic features outcomes in PDAC. We enrolled 426...
Recent advances in speaker embeddings promote a great development of diarization. However, determining ‘who spoke when’ the meeting scenarios is still challenging due to similar voices and unknown quantity. In this paper, research proposes enhanced discriminative features for diarization, including speaker-specific based on Siamese networks, re-verification method. With architecture, SiamTDNN, first explores latent representations which capable modeling intra-class inter-class differences...
Abstract Background Extracellular vesicles (EVs) contain long RNAs that reflect their tissue origins and the relative fractions of different immune cell types. This study examined molecular basis traditional Chinese Medicine ZHENG diagnoses (also called syndrome differentiation) in pancreatic ductal adenocarcinoma (PDAC). Methods A total 128 PDAC patients with were retrospectively reviewed this study. The EV RNA profile plasma samples was analyzed by sequencing. Differentially regulated...