A5100379317- Cancer-related gene regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Biomedical Text Mining and Ontologies
- Congenital heart defects research
- Circular RNAs in diseases
- Kruppel-like factors research
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Advanced Proteomics Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Chronic Lymphocytic Leukemia Research
- Lipoproteins and Cardiovascular Health
- Genetics, Bioinformatics, and Biomedical Research
- Sarcoma Diagnosis and Treatment
- Gene expression and cancer classification
- Pancreatic function and diabetes
- Chromatin Remodeling and Cancer
Shanghai Medical College of Fudan University
2024
Markey Cancer Center
2023
University of Kentucky
2023
Shanghai Xuhui Central Hospital
2023
Fudan University
2023
Sichuan University
2021
West China Hospital of Sichuan University
2021
Cedars-Sinai Medical Center
2015-2019
University of Chicago
2017-2018
Soochow University
2017
Long non-coding RNAs (lncRNAs) are expressed in tissue-specific pattern, but it is not clear how these regulated. We aimed to identify squamous cell carcinoma (SCC)-specific lncRNAs and investigate mechanisms that control their expression function.We studied patterns functions of 4 SCC-specific lncRNAs. obtained 113 esophageal SCC (ESCC) matched non-tumor tissues from a hospital Shantou City, China, performed quantitative reverse transcription polymerase chain reaction assays measure levels...
Squamous cell carcinomas (SCCs) are aggressive malignancies. Previous report demonstrated that master transcription factors (TFs) TP63 and SOX2 exhibited overlapping genomic occupancy in SCCs. However, functional consequence of their frequent co-localization at super-enhancers remains incompletely understood. Here, epigenomic profilings different types SCCs reveal cooperatively lineage-specifically regulate long non-coding RNA (lncRNA) CCAT1 expression, through activation its promoter....
Objective— We sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and determine impact baseline statin aspirin use on mortality. Approach Results— Coronary computed tomographic angiography permits direct visualization CAD. To date, prognostic implications CAD potential benefit directing therapy based have not been carefully examined. A total 27 125 consecutive patients who underwent (12 enrolling centers 6 countries) were prospectively entered...
Mutations of the Wnt5a gene, encoding a ligand non-canonical Wnt pathway, and Ror2 its receptor, have been found in patients with cardiac outflow tract defects. We that is expressed second heart field (SHF), population progenitor cells destined to populate right ventricle. Because phenotype similarities between Tbx1 mutant mice, we tested potential interactions two genes. strong genetic interaction vivo determined loss both genes caused severe hypoplasia SHF-dependent segments heart....
While oesophageal squamous cell carcinoma remains infrequent in Western populations, the incidence of adenocarcinoma (EAC) has increased sixfold to eightfold over past four decades. We aimed characterise cancer-specific and subtypes-specific gene regulation patterns their upstream transcription factors (TFs). DESIGN: To identify regulatory elements, we profiled fresh-frozen normal samples, tumours lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematical modelling was...
As the second most common malignant bone tumor in children and adolescents, Ewing sarcoma is initiated exacerbated by a chimeric oncoprotein, commonly, EWS-FLI1. In this study, we apply epigenomic analysis to characterize transcription dysregulation cancer, focusing on investigation of super-enhancer its associated transcriptional regulatory mechanisms. We demonstrate that super-enhancer-associated transcripts are significantly enriched EWS-FLI1 target genes, contribute aberrant network...
Ezh2 is a histone trimethyltransferase that silences genes mainly via catalyzing trimethylation of 3 lysine 27 (H3K27Me3). The role as regulator gene silencing and cell proliferation in cancer development has been extensively investigated; however, its function heart during embryonic cardiogenesis not well studied. In the present study, we used genetically modified mouse system which was specifically ablated heart. We identified wide spectrum cardiovascular malformations mutant mice,...
Purpose: Protocadherin 10 (PCDH10), a homophilic cell adhesion member of the protocadherin family, plays important roles in calcium-dependent cell-cell and signal transduction. PCDH10 expression is downregulated number different mali
Lipid overload is intimately connected with the change of endothelial epigenetic status which impacts cellular signaling activities and function. Activating transcription factor 4 (ATF4) involved in regulation lipid metabolism meanwhile an modifier. However, role ATF4 angiogenesis under not well understood. Here, to induce status, we employed high-fat diet (HFD)-induced obese mouse model vivo palmitic acid (PA) stimulate cells vitro. Compared mice fed normal chow (NCD), HFD-induced showed...
Genetic diseases are currently diagnosed by functional mutations. However, only some mutations associated with disease. It is necessary to establish a quick prediction model for clinical screening. Pathogenic in NGLY1 cause rare autosomal recessive disease known as congenital disorder of deglycosylation (NGLY1-CDDG). Although NGLY1-CDDG can be through gene sequencing, relevance detected mutation needs further confirmed. In this study, taken an example, comprehensive and practical predictive...
Aberrant interplay between epigenetic reprogramming and hypoxia signaling contributes to renal cell carcinoma progression drug resistance, which is an essential hallmark. How the chromatin remodelers enhance RCC malignancy remains be poorly understood. We aimed elucidate roles of CHD1L in determining activation sunitinib resistance. The qRT-PCR, western blotting, immunohistochemistry technologies were used detect expressions. Lentivirus transfection was generate stable CHD1L-KD cells....
Poly-D-L lactide (PDLLA) biodegradable implants to heal fractures are widely applied in orthopedic surgeries. However, whether the process of fracture healing is regulated differently when PDLLA used compared with traditional metal materials remains unclear. Runt‑related transcription factor 2 (Runx2) and canonical Wnt signaling essential may interact reciprocally regulation osteogenesis during bone repair. In present study, a rat femoral open osteotomy model was compare curative efficacy...
Genome instability in cancer cells causes not only point mutations but also structural variations of the genome, including copy number (CNVs). It has recently been proposed that CNVs arise to adapt a given microenvironment survive. However, how CNV influences cellular resistance against ionizing radiation remains unknown. PRMT5 (protein arginine methyltransferase 5) and APE1 (apurinic/apyrimidinic endonuclease 1), which enhance repair DNA double-strand breaks oxidative damage, are closely...
<p>PDF file - 446K, Supplemental Figure 6 Immunohistochemistry for Nox4 and HIF-2alpha in 786-0 NS KD xenograft explants confirms re-expression of tumors with corresponding elevated expression. Magnification 200X.</p>
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