A5100363167- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Hippo pathway signaling and YAP/TAZ
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Lipid metabolism and biosynthesis
- Kruppel-like factors research
- Ubiquitin and proteasome pathways
- Prostate Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Parathyroid Disorders and Treatments
- Nanoplatforms for cancer theranostics
Huazhong University of Science and Technology
2016-2025
Union Hospital
2016-2025
Wuhan Union Hospital
2008-2025
Union Hospital
2016-2024
Jiaxing University
2016-2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Zunyi Medical University
2023-2024
Capital Medical University
2021-2024
Beijing Anzhen Hospital
2021-2024
Abstract Objective To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. Design Retrospective case series. Setting Tongji Hospital in Wuhan, China. Participants Among a cohort 799 patients, 113 died and 161 recovered diagnosis covid-19 were analysed. Data collected until 28 February 2020. Main outcome measures Clinical laboratory findings obtained from electronic medical records data collection forms. Results The median age deceased (68...
Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon (GCGR) dual agonist that reduces body weight in obese subjects through increased energy expenditure and decreased intake. The metabolic effects of OXM have been attributed primarily to GLP1R agonism. We examined whether long acting GLP1R/GCGR exerts diet-induced mice are distinct from those obtained with GLP1R-selective agonist.We developed protease-resistant agonist, DualAG, corresponding GLPAG, matched for...
Background. X-linked hypophosphatemia (XLH) is the most common heritable form of rickets and osteomalacia. XLH-associated mutations in phosphate-regulating endopeptidase (PHEX) result elevated serum FGF23, decreased renal phosphate reabsorption, low concentrations (inorganic phosphorus, Pi) 1,25-dihydroxyvitamin D [1,25(OH)2D]. KRN23 a human anti-FGF23 antibody developed as potential treatment for XLH. Here, we have assessed safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD),...
Abstract Immune checkpoint blockade of the inhibitory immune receptors PD-L1, PD-1 and CTLA-4 has emerged as a successful treatment strategy for several advanced cancers. Here we demonstrate that miR-424(322) regulates PD-L1/PD-1 CD80/CTLA-4 pathways in chemoresistant ovarian cancer. is inversely correlated with PD-1, CD80 expression. High levels tumours are positively progression-free survival cancer patients. Mechanistic investigations demonstrated inhibited PD-L1 expression through direct...
Abstract Background Since late December, 2019, an outbreak of pneumonia cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and continued to spread throughout China across globe. To date, few data on immunologic features Coronavirus Disease 2019 (COVID-19) have been reported. Methods In this single-centre retrospective study, a total 21 patients with who were laboratory-confirmed be infected SARS-CoV-2 Wuhan Tongji hospital included from Dec 19,...
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear. We investigate effect of on glucose metabolism and malignancy CRC. find upregulates expression a cholesterogenic gene, Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1), during inhibition CRC cell aerobic glycolysis proliferation. In addition, downregulation FDFT1 correlated with malignant progression poor prognosis...
Hereditary transthyretin-mediated (hATTR) amyloidosis is a rare, inherited, progressively debilitating, and often fatal disease caused by deposition of mutated transthyretin (TTR) protein. Patisiran an RNA interference therapeutic comprising novel small interfering ribonucleic acid (ALN-18328) formulated with 2 lipid excipients, DLin-MC3-DMA PEG2000 -C-DMG, in nanoparticle targeted to inhibit hepatic TTR synthesis. Here we report the pharmacokinetics (PK) ALN-18328, DLin-MC3-DMA, -C-DMG from...
In X-linked hypophosphatemia (XLH), elevated fibroblast growth factor 23 (FGF23) decreases the renal tubular maximum reabsorption rate of phosphate/glomerular filtration (TmP/GFR) and serum inorganic phosphorus (Pi), resulting in rickets and/or osteomalacia. The objective was to test hypothesis that monthly KRN23 (anti-FGF23 antibody) would safely improve Pi adults with XLH. Two sequential open-label phase 1/2 studies were done. Six academic medical centers used. Twenty-eight XLH...
Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark several neurodegenerative diseases including Alzheimer's disease. In vivo detection NFTs using PET imaging represents a unique opportunity to develop pharmacodynamic tool accelerate discovery new disease modifying therapeutics targeting pathology. Herein, we present 6-(fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine, 6 ([(18)F]-MK-6240), novel tracer for...
Although microRNAs (miRNA) have been revealed as crucial modulators of tumorigenesis, our understanding their roles in renal cell carcinoma (RCC) is limited. Here we sought to identify human miRNAs that act key regulators carcinogenesis.We performed microarray-based miRNA profiling clear RCC (ccRCC) and adjacent normal tissues then explored the miR-141 both vitro vivo, which was most significantly downregulated ccRCC tissues.A total 74 were dysregulated compared with tissues. remarkably...
Renal cell carcinoma (RCC) is one of the most frequently observed malignant tumours in urinary system and targeted drug resistance quite common RCC. Long noncoding RNA SNHG12 (lncRNA SNHG12) has emerged as a key molecule numerous human cancers, but its functions renal sunitinib remain unclear. In this study, we found was highly expressed RCC tissues sunitinib-resistant cells associated with poor clinical prognosis. promoted proliferation, migration, invasion via CDCA3 vitro. Mechanically,...
Endowed with the expected visions for future surgery, minimally invasive surgery (MIS) has become one of most rapid developing areas in modern surgery. Soft robotics, which originates from interdisciplinary advances materials, fabrication, and electronics, featuring better adaptability safer interaction, holds great promises addressing current technical challenges MIS, are difficult to be solved rigid robotic technologies. For first time, herein, characteristics next‐generation MIS surgeons’...
We previously performed microRNA (miRNA) microarray to identify effective indicators of clear cell renal carcinoma (ccRCC) tissue samples and preoperative/postoperative plasma in which we identified miR-144-3p as an oncomiRNA. However, the molecular mechanism remains unclear. This study aims explore roles invasion, migration Sunitinib-resistance ccRCC elucidate underlying mechanisms.Gain loss function approaches were used investigate proliferation, cycle distribution, clonogenicity,...
Current endocrine therapy for prostate cancer (PCa) mainly inhibits androgen/androgen receptor (AR) signaling. However, due to increased intratumoural androgen synthesis and AR variation, PCa progresses castration-resistant (CRPC), which ultimately becomes resistant therapy. A search new therapeutic perspectives is urgently needed. Methods: By screening lipid metabolism-related gene sets bioinformatics analysis in database, we identified the key genes PCa. Bisulfite genomic Sequence...
Abstract Clear cell renal carcinoma (ccRCC) is the most common malignant tumor of kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis prognosis. The CENP family overexpressed many types cancers, but its functions have not been fully clarified. In this paper, we found that several members were highly expressed tissues. Also, CENPA expression level was related to clinicopathological grade prognosis by weighted gene co-expression network analysis (WGCNA). served as a...
Renal cell carcinoma (RCC) is a serious threat to people's health due its rapid progression, and patients easily develop resistance targeted therapy.The absent in melanoma 2 (AIM2) receptor protein that has recently been proposed play an important role various diseases.In this study, AIM2 was identified as new biomarker of RCC promoted progression sunitinib inflammasome-independent manner.Mechanistically, FOXO3a phosphorylation proteasome degradation, thereby reducing transcriptional effect...
The mechanism of metabolism reprogramming is an unsolved problem in clear cell renal carcinoma (ccRCC). Recently, it was discovered that the Hippo pathway altered tumor and promoted progression. Thus, this study aimed at identifying key regulators ccRCC pinpointing potential therapeutic targets for patients.Hippo-related gene sets metabolic were used to screen ccRCC. Public databases samples from patients applied investigate association dihydrolipoamide branched chain transacylase E2 (DBT)...
Noncanonical Wnt signaling by WNT5a has oncogenic and tumor suppressive activities, but downstream pathways mediating these specific effects remain to be fully established. In a subset of prostate cancer organoid culture xenograft models, inhibition synthesis stimulated growth, whereas or mimetic peptide (Foxy5) markedly suppressed growth. caused ROR2-dependent decrease in YAP1 activity, which was associated with increased phosphorylation MST1/2, LATS1, MOB1, YAP1, indicating Hippo pathway...
Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear-cell renal cell carcinoma (ccRCC). N-acetyltransferase 10 (NAT10) known to catalyze N4-acetylcytidine (ac
Clear cell carcinoma of the kidney is a major cause mortality in patients with von Hippel-Lindau (VHL) disease, which caused by germ line mutations that inactivate VHL tumor suppressor gene. Biallelic inactivation, due to or hypermethylation, also common sporadic clear renal carcinomas. The gene product, pVHL, part ubiquitin ligase complex targets alpha subunits heterodimeric transcription factor hypoxia-inducible (HIF) for destruction under well-oxygenated conditions. All linked classical...