A5054065249- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Anesthesia and Pain Management
- Immune cells in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Protein Structure and Dynamics
- Inflammatory Biomarkers in Disease Prognosis
- Enhanced Recovery After Surgery
- Chemokine receptors and signaling
- Nuclear Receptors and Signaling
- Cancer, Hypoxia, and Metabolism
- Thyroid and Parathyroid Surgery
- Airway Management and Intubation Techniques
- ATP Synthase and ATPases Research
- Computational Drug Discovery Methods
- Dietary Effects on Health
- Machine Learning in Bioinformatics
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Thermal Regulation in Medicine
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Gene Regulatory Network Analysis
Fudan University Shanghai Cancer Center
2015-2024
Tsinghua University
1996-2024
Soochow University
2024
Shanghai Medical College of Fudan University
2017-2024
Shanghai Cancer Institute
2022
The University of Texas MD Anderson Cancer Center
2016
Zero to Three
2016
Fudan University
2014-2015
Center for Life Sciences
2013
Neutrophil extracellular traps (NETs) production is a major strategy employed by polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been implicated in the pathogenesis of various lung injuries, although few studies explored sepsis-associated acute injury (SI-ALI). Here, we demonstrate contribution pathology ALI inducing ferroptosis alveolar epithelial cells. Using both vitro and vivo studies, our findings show enhanced accumulation patients mice, as well closely...
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear. We investigate effect of on glucose metabolism and malignancy CRC. find upregulates expression a cholesterogenic gene, Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1), during inhibition CRC cell aerobic glycolysis proliferation. In addition, downregulation FDFT1 correlated with malignant progression poor prognosis...
// Pengfei Sun 1, * , Huihui Wang Zhiyong He Xiangyuan Chen 1 Qichao Wu Wankun Zhirong Meilin Weng Minmin Zhu Duan Ma 2 and Changhong Miao Department of Anesthesiology, Fudan University Shanghai Cancer Center, Oncology, Medical College, University, Shanghai, China Key Laboratory Metabolism Molecular Medicine, Ministry Education, Biochemistry Biology, Collaborative Innovation Center Genetics Development, Institutes Biomedical Sciences, School Basic These authors have contributed equally to...
Abstract Sepsis is a systemic inflammation caused by infection. The balance between M1–M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, exact mechanism underlying unclear. We previously showed that levels malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) were significantly elevated septic patients compared with those nonseptic patients, and involved activation Toll-like receptor (TLR) 2/c-Jun N-terminal kinase (JNK)/nuclear factor (NF)- κ B...
Abstract Kallikrein-related peptidase 8 (KLK8) acts as an oncogene or anti-oncogene in various tumours, and the abnormal expression of KLK8 is involved carcinogenesis several tumours. However, role colorectal cancer (CRC) underlying mechanism remain largely unclear. In this study, carcinogenic effect was determined via CCK-8 colony formation assays vitro a xenograft model nude mice vivo. The metastasis-promoting investigated with transwell migration invasion wound-healing assay metastasis...
Abstract Diabetic kidney disease (DKD), a primary microvascular complication arising from diabetes, may result in end‐stage renal disease. Epigenetic regulation of endothelial mesenchymal transition (EndMT) has been recently reported to exert function metabolic memory and DKD. Here, we investigated the mechanism which Sirt7 modulated EndMT human glomerular cells (HGECs) occurrence Lower levels SDC1 were noted glomeruli both DKD patients diabetes‐induced injury rats, as well with high blood...
Malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) is a predicted oncoprotein that demonstrates tumorigenic activity in vivo; however, the mechanisms involved are unknown. Macrophages divided into pro-inflammatory M1 and anti-inflammatory/protumoral M2 subtypes. Tumor cells can induce polarization of tumor-associated macrophages (TAMs) to promote metastasis; but underlying pathways require be elucidated. In this study, we detected positive association between MFHAS1 expression TAMs...
Gamma-Aminobutyric Acid Type B Receptor (GABABR) plays essential roles in tumor progression.However, the function of GABABR colorectal cancer (CRC) needs further clarification.As main part GABABR, GABABR1 expression was identified significantly lower tissues than those non-tumor normal and that CRC patients with high lived longer.Further studies indicated knockdown elevated cell proliferation, migration, invasion.Furthermore, activated epithelial-mesenchymal transition (EMT)-related proteins...
Intravenous lidocaine has been shown to reduce opioid consumption and is associated with favourable outcomes after surgery. In this study, we explored whether intraoperative reduces use length of stay (LOS) improves long-term survival primary debulking surgery for ovarian cancer the correlation between SCN9A expression prognosis.This retrospective study included patients who underwent surgery(PDS) from January 2015 December 2018. The were divided into non-lidocaine [bolus injection 1.5 mg/kg...
Abstract Background: Surgical stress has been suggested to facilitate colon cancer growth and metastasis. However, the precise mechanisms by which surgical trauma promotes progression remain poorly understood. Methods: To unravel underlying surgery‐induced progression, a syngenic transplantation tumor model was established with CT26 cells, effect of laparotomy on investigated. Especially, expression several chemokines assessed, their roles in recruiting CD4+ CD25+ regulatory T cells (Tregs)...
Objective An acute severe stress response associated with major surgery can adversely affect the inflammatory and hormonal responses. We hypothesised that total intravenous anaesthesia (TIVA) combined thoracic epidural analgesia (TEA) attenuates postoperative pain in patients undergoing radical oesophagectomy. Methods Forty scheduled for elective oesophagectomy were randomly assigned to one of two groups: TIVA or TIVA+TEA. The plasma levels hormones cytokines, consumption fentanyl, visual...
Abstract How complex interactions of genetic, environmental factors and aging jointly contribute to dopaminergic degeneration in Parkinson's disease (PD) is largely unclear. Here, we applied frequent gene co‐expression analysis on human patient substantia nigra ‐specific microarray datasets identify potential novel disease‐related genes. In vivo Drosophila studies validated two 32 candidate genes, a chromatin‐remodeling factor SMARCA4 biliverdin reductase BLVRA. Inhibition was able prevent...
Perioperative hypothermia and shivering are common can cause adverse outcomes. The aim of this study was to investigate the incidence postoperative their risk factors in patients undergoing malignant tumor surgery.This retrospective collected data from with American Society Anesthesiologists physical status (ASA) I or II who underwent scheduled surgery November 2020 March 2021 at Fudan University Shanghai Cancer Center. Each patient's core body temperature measured three time points: point 1...
Morphine is postulated a risk factor in promoting tumor growth and metastasis during the preoperative period, high glycolysis of cells proved to accelerate progression. In this study, we investigated whether nalmefene, an opioid receptor inhibitor, could inhibit CT26 colon cancer cell through influencing glycolysis. CCK8 transwell migration assays showed that nalmefene inhibited viability concentration-dependent manner. Extracellular acidification rate oxygen consumption cells. Moreover,...