A5026316177- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Kruppel-like factors research
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Retinal Diseases and Treatments
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Traditional Chinese Medicine Analysis
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Photosynthetic Processes and Mechanisms
- T-cell and B-cell Immunology
- Retinal Development and Disorders
- FOXO transcription factor regulation
- Retinal Imaging and Analysis
- Fungal Biology and Applications
- Gastroesophageal reflux and treatments
Sun Yat-sen University
2014-2025
Sun Yat-sen University Cancer Center
2018-2025
Wenzhou Medical University
2014-2025
Affiliated Eye Hospital of Wenzhou Medical College
2014-2025
Shanghai Cancer Institute
2025
Shanghai Jiao Tong University
2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2023
Zhongshan Hospital
2012-2023
Fudan University
2012-2023
State Key Laboratory of Oncology in South China
2021-2023
Acute lung injury (ALI) is a critical clinical condition with high mortality rate, characterized excessive uncontrolled inflammation and apoptosis. Recently, microRNAs (miRNAs) have been found to play crucial roles in the amelioration of various inflammation-induced diseases, including ALI. However, it remains unknown biological function regulatory mechanisms miRNAs regulation inflammation apoptosis The aim this study identify evaluate potential role ALI reveal underlying molecular their...
Pancreatic ductal adenocarcinoma (PDAC) relies heavily on glutamine (Gln) utilization to meet its metabolic and biosynthetic needs. How epigenetic regulators contribute the flexibility PDAC's response adaptation Gln scarcity in tumor milieu remains largely unknown. Here, we elucidate that prolonged restriction or treatment with antagonist, 6-diazo-5-oxo-L-norleucine (DON), leads growth inhibition ferroptosis program activation PDAC. A CRISPR-Cas9 screen identifies an regulator, Paxip1, which...
Background: In this study, a deep convolutional neural network (CNN)-based automatic segmentation technique was applied to multiple organs at risk (OARs) depicted in computed tomography (CT) images of lung cancer patients, and the results were compared with those generated through atlas-based segmentation.Materials methods: An encoder-decoder U-Net produced. The trained CNN performed CT for 36 cases cancer. Dice similarity coefficient (DSC), mean surface distance (MSD) 95% Hausdorff (95% HD)...
Transforming growth factor-β1 (TGF-β1) and -β2 are correlated with poorer prognosis in gastric cancer (GC), which act both tumor immune cells. However, their expressions precancer tumor-cell interactions peripheral blood mononuclear cells (PBMCs) remain unclear. Protein levels of TGF-β1 were analyzed by immunohistochemistry corresponding mRNA determined quantitative real-time polymerase chain reaction 93 surgical biopsy specimens. Serum TGF-β concentration was detected enzyme-linked...
The effect of ginsenoside Rb1 on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver injury (ALI) is unknown. aim this study was to evaluate the ALI and its underlying mechanisms.Mice were pretreated with by intraperitoneal injection for 3 days before D-GalN/LPS treatment, induce ALI. survival rate monitored every hour 24 h, serum biochemical parameters, hepatic index histopathological analysis evaluated measure degree injury. ELISA used detect oxidative stress inflammatory...
For many centuries, Gardenia (Gardenia jasminoides Ellis) was highly valued as a food homologous Chinese herbal medicine with various bioactive compounds, including crocin I and geniposide. However, the functional mechanism underlying hypoglycemic effect of gardenia is absent in literature. To evaluate its different extracts on type 2 diabetes mellitus (T2DM) vivo vitro experiments, dried powder extracted using 60% ethanol eluted at concentrations to obtain corresponding purified fragments....
Abstract Purpose We aimed to perform the commissioning and clinical evaluation of myQA SRS detector array for patient‐specific quality assurance (PSQA) stereotactic radiosurgery (SRS)/ body radiotherapy (SBRT) plans. Methods To SRS, its dose linearity, dose‐rate dependence, angular field‐size dependence were investigated. Ten SBRT plans selected evaluation: 1) Common deviations based on original plan (Plan0), including multileaf collimator (MLC) positioning deviation treatment introduced. 2)...
Summary In cereal crops, ABA deficiency during seed maturation phase causes pre‐harvest sprouting ( PHS ), and molybdenum cofactor (MoCo) is required for biosynthesis. Here, two rice mutants F254 F5‐1 were characterized. addition to the , these showed pleiotropic phenotypes such as twisting slender leaves, then died when seedling developed four or five leaves. Map‐based cloning that Os CNX 6 1 encoding homologs of MoaE MoeA responsible mutants, respectively. Genetic complementation indicated...
Purpose: Changes associated with Alzheimer's disease (AD) may have measurable effects on the retina, which facilitate early detection due to eye's accessibility. Retinal pathology and regulation of serine racemase (SR) were investigated in retinas APP(SW)/PS1(∆E9) mice. Methods: SR content D-serine aqueous humor analyzed. The structure function retina assessed. Additionally, primary Müller cell cultures was investigated. Results: levels significantly higher 18- 24-month-old male APP/PS1...
This study evaluates the contouring variability among observers using MR images reconstructed by different sequences and quantifies differences of automatic segmentation models for sequences. Eighty-three patients with pelvic tumors underwent T1-weighted image (T1WI), contrast enhanced Dixon (T1dixonc), T2-weighted (T2WI) imaging on a simulator. Two performed manual delineation bladder, anal canal, rectum, femoral heads all images. Contour were used to analyze interobserver intersequence...
Abstract Choroidal neovascularization ( CNV ) is a leading cause of blindness in age‐related macular degeneration. Production vascular endothelial growth factor VEGF and macrophage recruitment by retinal pigment epithelial cells RPE significantly contributes to the process an experimental model. Serine racemase SR expressed neurons glial cells, its product, d ‐serine, endogenous co‐agonist N ‐methyl‐ ‐aspartate receptor. Activation receptor results production nitric oxide . NO ), molecule...
Abstract In this study, a strategy to print hydroxyapatite (HA) ceramics based on falling‐down‐type digital light processing (DLP) 3D printing technology with high accuracy was proposed. The monolayer curing thickness and broadening of the samples were compared under different conditions, most suitable photoinitiator for system optimal amount additive dye in slurry obtained. power density single‐layer exposure time source DLP printer optimized, number high‐resolution models HA scaffolds an...
The extracellular polymeric substances (EPS) are important macromolecular components in microbial aggregates. three EPS extraction methods – ultrasound + cation exchange resins (CER) sulfide, formamide NaOH, and heat were investigated the study, component differences of extracted from loose flocs dense aerobic granules compared using chemical analysis three-dimensional excitation-emission matrix (3D-EEM). Results showed that contents effectively by NaOH methods, CER sulfide method did not...
Ulinastatin, a urinary trypsin inhibitor (UTI) is commonly used to treat patients with acute inflammatory disease. However, the underlying mechanisms of its anti‑inflammatory effect in lung injury (ALI) are not fully understood. The present study aimed investigate protective UTI and explore potential by using rat model lipopolysaccharide (LPS)‑induced ALI. Rats were treated 5 mg/kg LPS intratracheal instillation. histological changes LPS‑induced ALI was evaluated hematoxylin eosin staining...
Evidence indicates that the ubiquitin‐proteasome system and endoplasmic retculum (ER) quality‐control work in concert to ensure proteins are correctly folded ER misfolded retrotransported cytosol for degradation by proteasomes. Dysfunction of either results developmental abnormalities even death animals. This study investigates whether how proteasome inhibition impacts components calreticulin (CRT)/calnexin (CNX) glycoprotein folding machinery, a typical protein system, context early...
Background KIT proto‐oncogene ligand (KITLG) is a pleiotropic factor which found in diverse cancers and involved cell proliferation, differentiation, survival. However, the value of KITLG thymoma remains unclear. Methods A total 121 samples from The Cancer Genome Atlas Thymoma (TCGA‐THYM) dataset were used to analyze related genome‐wide expression profiles, microRNA profiles methylation alterations GEO dataset‐GSE29695, including 37 was as verification. For cell‐based studies, specific small...
Dried Whitmania pigra is used for the treatment of cardiovascular and cerebrovascular diseases in traditional Chinese medicine hot water alcohol extracts also have anticogulant activity. However, a lower molecular weight more stable needed.The objective following study to purify characterize an anticoagulant oligopeptide from Hirudo (Whitmania Whitman).Gel filtration on Sephadex G-50, ion exchange diethylaminoethyl-cellulose, semi-prepared high-performance liquid chromatography were Hirudo....