A5101822259- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Nausea and vomiting management
- Enhanced Recovery After Surgery
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Neuroscience and Neuropharmacology Research
- Dermatology and Skin Diseases
- Congenital heart defects research
- Sleep and Wakefulness Research
- Opioid Use Disorder Treatment
- Epigenetics and DNA Methylation
- Pain Management and Opioid Use
- Genetics and Neurodevelopmental Disorders
- Renal Transplantation Outcomes and Treatments
- Fetal and Pediatric Neurological Disorders
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2016-2025
National Natural Science Foundation of China
2018
Shanghai Medical College of Fudan University
2005-2016
Green Technology
2015
Acute lung injury (ALI) is a critical clinical condition with high mortality rate, characterized excessive uncontrolled inflammation and apoptosis. Recently, microRNAs (miRNAs) have been found to play crucial roles in the amelioration of various inflammation-induced diseases, including ALI. However, it remains unknown biological function regulatory mechanisms miRNAs regulation inflammation apoptosis The aim this study identify evaluate potential role ALI reveal underlying molecular their...
The effectiveness and safety of opioid-free anesthesia (OFA) regimens in distinct types surgeries remain controversial. In this study, we investigated whether OFA could reduce the occurrence chronic postoperative pain patients receiving video-assisted thoracoscopic surgery (VATS).We conducted a 2-center, randomized, controlled trial from September 2021 to January 2022. A total 162 lung tumor scheduled undergo VATS were randomly divided into an opioid-based (OA) group group. OA received...
Abstract Background Rebound pain after a single-shot nerve block challenges the real benefit of this technique. We aimed to investigate whether perineural dexamethasone addition decreased incidence rebound block. Methods randomly allocated 132 patients scheduled for open reduction internal fixation an upper extremity closed fracture under peripheral and sedation into two groups. Patients in group received with 0.375% ropivacaine 8 mg dexamethasone, while those control only. Sixty-three 60...
Abstract Sleep is ubiquitous and essential, but its mechanisms remain unclear. Studies in animals humans have provided insights of sleep at vastly different spatiotemporal scales. However, challenges to integrate local global information sleep. Therefore, we developed fMRI based on simultaneous electrophysiology 9.4 T male mice. Optimized un-anesthetized mouse setup allowed manifestation NREM REM sleep, a large dataset was collected openly accessible. State dependent patterns were revealed,...
Rosuvastatin, a member of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, exerts various pharmacological activities. This study evaluated the cardioprotective effect rosuvastatin on isoproterenol-induced myocardial infarction injury in rats. rat model was induced by isoproterenol (ISO) for 2 consecutive days, administered 8 weeks. The levels infarct size, aspartate transaminase (AST), alanine (ALT), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) activities, as well...
Perioperative ischemic stroke usually leads to neurological dysfunction caused by neuron death. During the condition, excitotoxity due extracellular glutamate accumulation is a main mechanism of damage. The clearance mainly depends on transporter-1 (GLT-1) which expressed in astrocytes. Dexmedetomidine, an α2 adrenergic receptor agonist, proved induce neuroprotection. This study was set out investigate glutamate-related involved neuroprotective effect dexmedetomidine. Middle cerebral artery...
MECP2 gain-of-function and loss-of-function in genetically engineered monkeys recapitulates typical phenotypes patients with autism, yet where mutation affects the monkey brain whether/how it relates to autism pathology remain unknown. Here we report a combination of gene–circuit–behavior analyses including coexpression network, locomotive cognitive behaviors, EEG fMRI findings 5 overexpressed ( Macaca fascicularis ; 3 females) 20 wild-type 11 females). Whole-genome expression analysis...
Maternal sevoflurane exposure during pregnancy is associated with increased risk for behavioral deficits in offspring. Several studies indicated that neurogenesis abnormality may be responsible the sevoflurane-induced neurotoxicity, but concrete impact of on fetal brain development remains poorly understood. We aimed to investigate whether maternal caused learning and memory impairment offspring through inducing abnormal prefrontal cortex (PFC). Pregnant mice at gestational day 15.5 received...
Purpose CSF plays important roles in clearing brain waste and homeostasis. However, mapping whole‐brain flow the rodents is difficult, primarily due to its assumed very low velocity. Therefore, we aimed develop a novel phase‐contrast MRI method map mouse brain. Methods A generalized Hadamard encoding–based multi‐band scheme (dubbed HEAP‐METRIC, Encoding APproach of Multi‐band Excitation for short TR Imaging aCcelerating) using complex matrix was developed incorporated into conventional phase...
Abstract Background Exposure to general anesthesia influences neuronal functions during brain development. Recently, interneurons were found be involved in developmental neurotoxicity by anesthetic exposure. But the underlying mechanism and long-term consequences remain elusive. Methods Pregnant mice received 2.5% sevoflurane for 6-h on gestational day 14.5. Pentylenetetrazole (PTZ)-induced seizure, anxiety- depression-like behavior tests performed 30- 60-day-old male offspring. Cortical...
Background Accumulating evidence has revealed that the aspartate aminotransferase to alanine (AST/ALT) ratio is a promising novel biomarker for insulin resistance (IR) and metabolic diseases. However, research on association between AST/ALT incidence of diabetes progressing from prediabetes remains lacking. Herein, this study aimed evaluate relationship baseline risks in patients with prediabetes. Methods This was retrospective cohort involving total 82,683 participants across 32 regions 11...
Abstract Background The purpose of this randomized controlled trial was to determine if enhanced recovery after surgery (ERAS) would improve outcomes for three-stage minimally invasive esophagectomy (MIE). Methods Patients with esophageal cancer undergoing MIE between March 2016 and August 2018 were consecutively enrolled, randomly divided into 2 groups: ERAS+group that received a guideline-based ERAS protocol, ERAS- group standard care. primary endpoint morbidity MIE. secondary endpoints...
Pruritus is a prominent side effect of neuraxial opioids. an unpleasant sensation that leads to scratching and discomfort. This trial was aimed study nalmefene's efficacy for treating epidural opioid-induced pruritus its on postoperative patient-controlled analgesia (PCEA). We recruited 166 patients who developed due opioid analgesia. Patients were randomized the nalmefene group or control received either 0.5 µg/kg equivalent volume saline evaluate PCEA. The primary outcome complete relief...
Obesity and depression are major public health issues with a complex, bidirectional relationship potentially involving systemic inflammation. Using diverse sample from the National Health Nutrition Examination Survey (NHANES) (n = 11,324; weighted population 456,457,366), we examined associations between obesity, inflammation, depression. was classified by Body Mass Index (BMI), depressive symptoms were assessed Patient Questionnaire-9 (PHQ-9), inflammation measured using markers like...
Enhanced recovery after surgery (ERAS) protocols have been widely adopted to improve surgical outcomes. In this study, we aimed assess the current state of awareness and specific knowledge ERAS among Chinese anesthesiologists, examine difficulties in implementation, identify future priorities for education training. A self-designed, repeated national survey regarding practice concept, knowledge, learning modalities, implementation was conducted 2019, 2021, 2023. Factors related mastery were...
Thoracotomy results in severe postoperative pain potentially leading to chronic pain. We investigated the potential benefits of intravenous parecoxib on analgesia combined with thoracic epidural (TEA).Eighty-six patients undergoing surgery were randomized into two groups. Patient-controlled (PCEA) was used until chest tubes removed. Patients received (group P) or placebo C) intravenously just 0.5 h before operation and every 12 after for 3 days. The intensity measured by using a visual...
Propofol can cause degeneration of developing brain cells and subsequent long-term learning or memory impairment. However, at the early stage embryonic development, molecular mechanism propofol-induced inhibition in neural stem (NSCs) neurogenesis is still unclear. The aim this study was to determine role propofol NSCs and, more importantly, explore underlying mechanism.First, a single intraperitoneal injection performed pregnant mice, 6 hours after administration propofol, hippocampus RNA...
Abstract Objectives The effects of general anaesthetics on fetal brain development remain elusive. Radial glial progenitors (RGPs) generate the majority neurons in developing brains. Here, we evaluated acute alterations RGPs after maternal sevoflurane exposure. Methods Pregnant mice were exposed to 2.5% for 6 hours gestational day 14.5. Interkinetic nuclear migration (INM) ventricular zone (VZ) was by thymidine analogues labelling. Cell fate RGP progeny determined immunostaining using...