A5065933735- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Neuropeptides and Animal Physiology
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Cancer, Stress, Anesthesia, and Immune Response
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Hydrogen's biological and therapeutic effects
- Neuroscience and Neuropharmacology Research
- Obstructive Sleep Apnea Research
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric Pain Management Techniques
- Cardiac and Coronary Surgery Techniques
- Vagus Nerve Stimulation Research
- Nausea and vomiting management
- Respiratory Support and Mechanisms
- Enhanced Recovery After Surgery
- Tryptophan and brain disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- interferon and immune responses
- Acute Kidney Injury Research
General Hospital of Shenyang Military Region
2014-2025
Chinese People's Liberation Army
2024
Postoperative pain poses a significant challenge to the healthcare system and patient satisfaction is associated with chronic long-term narcotic use. However, systemic assessment of quality postoperative management in China remains unavailable.In this cross-sectional study, we analyzed data collected from nationwide registry, Acute Pain Study (CAPOPS), between September 2019 August 2021. Patients aged 18 years or above were required complete self-reported outcome questionnaire on first day...
Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, inhibit inflammation. This study investigated effects of HRS on induced by CPB regulatory mechanisms the PI3K/Akt/GSK3β signaling pathway.A rat model an in vitro cell hypoxia were established. After treatment, Rat behavior was measured using neurological deficit score; Evans blue (EB) used assess permeability blood-brain barrier (BBB);...
Myocardial ischemia, hypoxia and reperfusion injury are induced by aortic occlusion, cardiac arrest resuscitation during cardiopulmonary bypass (CPB), which can severely affect function. The aim of the present study was to investigate effects hydrogen‑rich solution (HRS) aquaporin (AQP) on (CPB)‑induced myocardial injury, determine mechanism phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway. Sprague Dawley rats were divided into a sham operation group, CPB surgery...
To compare the efficacy of remimazolam and propofol on hemodynamics quality early postoperative recovery in elderly patients with frailty undergoing endoscopic retrograde cholangiopancreatography (ERCP).
Enhanced recovery after surgery (ERAS) protocols have been widely adopted to improve surgical outcomes. In this study, we aimed assess the current state of awareness and specific knowledge ERAS among Chinese anesthesiologists, examine difficulties in implementation, identify future priorities for education training. A self-designed, repeated national survey regarding practice concept, knowledge, learning modalities, implementation was conducted 2019, 2021, 2023. Factors related mastery were...
Postoperative cognitive dysfunction (POCD) is a common complication following cardiopulmonary bypass (CPB). U50488H, κ‑opioid receptor (KOR) agonist, can specifically activate KORs on hippocampal nerve cells, resulting in neuroprotective effects. The present study established CPB rat model, observed the protective effect of U50488H CPB‑induced POCD and brain damage explored regulatory mechanism PI3K/AKT/nuclear factor erythroid 2‑related 2 (Nrf2)/heme oxygenase (HO)‑1 pathway. Sprague‑Dawley...
Backgrund/Aims: To investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR) on postoperative cognitive dysfunction (POCD) and intestinal injury induced by cardiopulmonary bypass (CPB) its relationship with Th17 response in order to provide a theoretical basis for organ protection targeted drug therapy during perioperative period. Methods: Sprague-Dawley rat models CPB were established. Rat brain injuries observed after using hematoxylin eosin staining. Cell...
Postoperative cognitive dysfunction (POCD) is a common and well‑known complication following surgery, particularly cardiopulmonary bypass (CPB) surgery. There are currently no suitable treatments for POCD, which associated with increased illness mortality rates. The present study aimed to identify novel treatment POCD. protective effect of kappa opioid receptor (KOR) agonists on POCD in rats CPB was determined the regulatory mechanism Janus kinase 2/signal transducer activator transcription...
This study investigated the effect of penehyclidine hydrochloride (PHC) on regulatory mediators during neuroinflammatory response and cerebral cell apoptosis following cardiopulmonary bypass (CPB). Forty-eight rats were randomly divided among 4 groups as follows: sham-operation, vehicle, low-dose PHC (0.6 mg·(kg body mass)(-1)), high-dose (2.0 mass)(-1)). CPB was performed in latter 3 groups. The plasma levels neuron specific enolase (NSE) S-100B tested with ELISA. Real-time PCR Western...
The present study aimed to investigate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) agonist on damage hippocampal neurons and expression toll like 4 (TLR4)/myeloid differentiation primary response 88 (Myd88)/nuclear factor (NF)‑κB signal pathway‑associated factors in cardiopulmonary bypass (CPB). Sprague Dawley rats were randomly divided into five groups: Sham operation (Sham); CPB; CPB + α7nAChR PHA568487 (PHA); inhibitor MLA (MLA); TLR4 antagonist (CPT). Blood brain tissue...
Off-pump coronary artery bypass grafting-associated acute kidney injury (OPCAB-AKI) is related to 30-day perioperative mortality. Existing mathematical models cannot be applied help clinicians make early diagnosis and intervention decisions.
Remifentanil preconditioning on cerebral injury 0.01), and was positively correlated with MDA density (T 2 : r = 0.71, P < 0.01; T 3 0.01).In conclusion, high-dosage remifentanil played a protective role brain damage, possibly through inhibition of the oxidative stress response.
Cardiopulmonary bypass (CPB) is mainly used during cardiac surgeries that treat ischemic, valvular, or congenital heart disease and aortic dissections. The disorders of central nervous system (CNS) occur after cardiopulmonary are attracting considerable interest. Postoperative neurocognitive (PND) have been reported as the leading cause patients’ disability death following CPB. k-opioid receptor (KOR) agonists (U50488H) suggested to be vital in treatment surgically induced CNS...
More literature studies have reported that alfentanil is safe and effective for labor analgesia. However, there no unified consensus on the optimal dosage of used epidural This study explored concentration at 90% minimum (EC90) combined with 0.075% ropivacaine in patients undergoing analgesia to infer reasonable drug compatibility provide guidance clinical practice.
1. In the present study, we investigated impact of 1.0% ropivacaine on ultrastructure and proteome rat spinal cord. 2. Rats received three injections (90-min intervals, 0.2 mL/kg) 0.9% NaCl, 0.5% or via an implanted intrathecal catheter. Transmission electron microscopy was performed to exam Two-dimensional electrophoresis followed by mass spectrometry identification were carried out investigate proteome. 3. rats administered ropivacaine, deformed organelles, detached myelinated nerve fiber...
Background: We compared the effectiveness and safety of endotracheal intubation using GlideScope (GS) video laryngoscope, CTrach laryngeal mask airway (LMA), or Shikani optical stylet rigid laryngoscope (SOS) during elective cervical surgery. Methods: Forty-five patients undergoing surgery were randomly equally assigned to via GS, LMA, SOS management. Results: Endotracheal was successfully completed in all patients. The mean times groups differed significantly (P < .01): 17.9 ± 3.1 s; SOS,...
Introduction Postoperative pain remains incompletely controlled for decades. Recently, multimodal analgesia is emerging as a potential approach in the management of postoperative pain. Therein, S(+)-ketamine appealing an adjuvant drug due to its unique pharmacological advantages. This pragmatic clinical trial (SAFE-SK-A trial) designed investigate analgesic effect and safety acute adults explore optimal strategy perioperative intravenous real-world setting. Methods analysis multicentre,...
The incidence of complications and mortality following open‑heart surgery with cardiopulmonary bypass (CPB) is associated the severity myocardial injury that occurs during surgery. Hydrogen‑rich solution (HRS) may prevent antioxidant stress inhibit apoptosis inflammation. present study was designed to investigate effects HRS on CPB‑induced injury, its potential regulation Janus‑activated kinase 2/signal transducer activator transcription 3 (JAK2/STAT3) pathway. treatment resulted in...
The aims of the present study were to investigate protective effect a κ-opioid receptor (KOR) agonist on intestinal barrier dysfunction in rats during cardiopulmonary bypass (CPB), as well examine role NF-κB and transcription factor hypoxia-inducible factor-1α (HIF-1α) signaling pathway regulatory mechanism. A total 50 randomly divided into five groups, with 10 each group: Sham surgery group (group Sham), CPB CPB), KOR + K), specific antagonist CBP NK) inhibitor NF). Intestinal...
Objective. This study was aimed at investigating the effects of different types fluid restriction resuscitation on immune dysfunction and organ injury hemorrhagic shock rats under a hypothermic environment. Methods. SD were divided into sham operation group (SHAM), model (HS), crystal liquid limited (CRLLR), colloidal (COLLR), nonlimited (NLR); in each placed low-temperature environment 0-5°C for 30 min, then, rat prepared. Sodium lactate Ringer’s restricted solution, hydroxyethyl starch...