A5101899435- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Nanoplatforms for cancer theranostics
- Health, Environment, Cognitive Aging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Pressure and Hypertension Studies
- Gut microbiota and health
- Cardiac Arrest and Resuscitation
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Anesthesia and Sedative Agents
- Luminescence and Fluorescent Materials
- Mycobacterium research and diagnosis
- Advanced Nanomaterials in Catalysis
- Emergency and Acute Care Studies
- Cardiovascular Health and Risk Factors
- Endometriosis Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Birth, Development, and Health
- Intergenerational Family Dynamics and Caregiving
- Respiratory Support and Mechanisms
- Cerebrovascular and Carotid Artery Diseases
Qilu Hospital of Shandong University
2021-2025
Shandong Provincial Hospital
2025
Beijing Chest Hospital
2023-2024
Capital Medical University
2021-2024
Tianjin Medical University
2018-2023
Shandong University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Qingdao University
2022
Affiliated Hospital of Qingdao University
2022
Imperial College London
2021
Checkpoint-blockade immunotherapy targeting programmed cell death protein 1 (PD-1) has recently shown promising efficacy in hepatocellular carcinoma (HCC). However, the factors affecting and predicting response to anti-PD-1 HCC are still unclear. Herein, we report dynamic variation characteristics specificities of gut microbiome during using metagenomic sequencing.Fecal samples from patients responding showed higher taxa richness more gene counts than those non-responders. For analysis...
Abstract Chemodynamic therapy (CDT) by introducing the Fenton‐/Fenton‐like reaction in an acidic and H 2 O environment for toxic hydroxyl radical (•OH) generation, is a newly developed tumor‐selective therapeutic. However, tumor acidosis, characterized extracellular acidity (pH e ≈ 6.5) intracellular alkalinity i 7.2), undoubtedly confers large chemical barrier effective implementation of CDT thus limits its functional activity therapeutic efficacy. Here, unique amorphous iron nanoparticles...
The impact of cardiovascular risk burden on cognitive trajectories and brain structure changes remains unclear.This study aimed to examine whether assessed by the Framingham General Cardiovascular Risk Score (FGCRS) is associated with decline structural differences.Within Rush Memory Aging Project, 1,588 dementia-free participants (mean age: 79.5 years) were followed for up 21 years. FGCRS was at baseline categorized into tertiles (lowest, middle, highest). Episodic memory, semantic working...
Out-of-hospital cardiac arrest (OHCA) is an important global public health issue, but its epidemiology and outcomes in low-income middle-income countries remain largely unknown. We aim to comprehensively describe the incidence, process of care, OHCA China.In prospective, multicentre, population-based Baseline Investigation Cardiac Arrest (BASIC-OHCA) registry study, participating sites were selected from both urban rural areas all seven geographical regions across China. All patients with...
Evidence on the association of lifespan cognitive reserve (CR) with dementia is limited, and strength this in presence brain pathologies unknown.
Free radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O2 and H2 deficiency in sets a severe barrier sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct chlorine radical (. Cl) nano-generator SiO2 -coated upconversion nanoparticles (UCNPs) on inside Ag0 /AgCl hetero-dots outside. Upon near-infrared (NIR) light...
The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and pathologies.
Evidence on the association of cognitive reserve (CR) with trajectories is limited. We aimed to examine influence CR indicator domain-specific taking brain pathologies into account.
Abstract Introduction The association of lifespan cognitive reserve (CR) with mild impairment (MCI) remains controversial. We aimed to examine the CR indicator risk MCI and its progression dementia, taking brain pathologies into account. Methods In a community‐based cohort study (mean age, 79 years) annual follow‐up (median, 5.16 years; maximum, 20 years), cognitively intact group (n = 1182) an 420) were identified at baseline. During follow‐up, 611 participants died underwent autopsies....
Abstract Introduction Whether depression is a prodromal phase or risk factor for dementia under debate. We aimed to unveil the nature of depression–dementia association by looking into time window occurrence. Methods Dementia‐free twins ( n = 41,727) from Swedish Twin Registry were followed‐up 18 years. Data analyzed using generalized estimating equation (GEE) all individuals and conditional logistic regression co‐twin matched pairs. Results In GEE model, multi‐adjusted odds ratios (ORs; 95%...
In this paper, we report the ion interference tumor therapy strategy by employing specific biological effects of Ba<sup>2+</sup> ions.
Perioperative ischemic stroke usually leads to neurological dysfunction caused by neuron death. During the condition, excitotoxity due extracellular glutamate accumulation is a main mechanism of damage. The clearance mainly depends on transporter-1 (GLT-1) which expressed in astrocytes. Dexmedetomidine, an α2 adrenergic receptor agonist, proved induce neuroprotection. This study was set out investigate glutamate-related involved neuroprotective effect dexmedetomidine. Middle cerebral artery...
Maternal sevoflurane exposure during pregnancy is associated with increased risk for behavioral deficits in offspring. Several studies indicated that neurogenesis abnormality may be responsible the sevoflurane-induced neurotoxicity, but concrete impact of on fetal brain development remains poorly understood. We aimed to investigate whether maternal caused learning and memory impairment offspring through inducing abnormal prefrontal cortex (PFC). Pregnant mice at gestational day 15.5 received...
Abstract Introduction The relationship between pulmonary function (PF) and mild cognitive impairment (MCI), dementia, brain pathologies remains unclear. Methods A total of 1312 dementia‐free participants, including a cognitively intact group (n = 985) an MCI 327), were followed for up to 21 years detect incident dementia. PF was assessed at baseline with composite score tertiled. Over follow‐up, 540 participants underwent autopsies neuropathological assessment. Results Compared the highest...
Abstract Adoptive T lymphocyte immunotherapy is one of the most promising methods to treat residual lesions after glioma surgery. However, fate adoptively transferred T‐cells in vivo unclear, hampering understanding this emerging therapy. Thus, it highly desirable develop noninvasive and quantitative tracking these for better identification migratory provide objective evaluation outcomes adoptive T‐cell targeting glioma. In work, ultrasmall 1 MR‐based nanoprobes, NaGdF 4 ‐TAT, as molecular...
Background The menstrual cycle is regulated by reproductive hormones such as estrogen which has been implicated in the pathogenesis of hypertension and associated with obesity. However, to date there scant study relation characteristics abnormalities. We hypothesize that adverse are an increase prevalence this relationship exacerbated Methods Our leverages 178,205 healthy female participants (mean age = 29) a population-based cross-sectional Tianjin, China. Menstrual including length...