A5101464990- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neuroscience of respiration and sleep
- Reproductive Biology and Fertility
- Cardiovascular and exercise physiology
- Reproductive Health and Technologies
- Aortic aneurysm repair treatments
- Emergency and Acute Care Studies
- Aortic Disease and Treatment Approaches
- Climate Change and Health Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ultrasound in Clinical Applications
- Thermal Regulation in Medicine
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Cardiovascular Issues in Pregnancy
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Neonatal and Maternal Infections
- Macrophage Migration Inhibitory Factor
- Pluripotent Stem Cells Research
- Trauma and Emergency Care Studies
- Nerve injury and regeneration
China-Japan Friendship Hospital
2013-2024
Qinghai University
2024
Peking Union Medical College Hospital
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Chinese PLA General Hospital
2023
Beijing Obstetrics and Gynecology Hospital
2008-2022
Capital Medical University
2018-2022
Henan Normal University
2020
McGill University
1992-2000
Hôpital Maisonneuve-Rosemont
2000
In patients with chronic obstructive pulmonary disease (COPD) and hyperinflation of the lungs, dysfunction diaphragm may contribute to respiratory decompensation. We evaluated contractile function in well-nourished stable COPD, using supramaximal, bilateral phrenic-nerve stimulation, which provides information about strength inspiratory action diaphragm.
Summary China faces a major increase in cardiovascular disease, yet there is limited population‐based data on risk factors, particularly children. Fasting blood samples, anthropometry and pressure were collected 9,244 children adults aged ≥7 years late 2009 as part of the national Health Nutrition Survey. Prevalent overweight, elevated pressure, cardiometabolic factors: glucose, HbA1c, triglycerides (TG), total cholesterol (TC), high‐ low‐density lipoprotein (HDL‐C LDL‐C), C‐reactive protein...
Out-of-hospital cardiac arrest (OHCA) is an important global public health issue, but its epidemiology and outcomes in low-income middle-income countries remain largely unknown. We aim to comprehensively describe the incidence, process of care, OHCA China.In prospective, multicentre, population-based Baseline Investigation Cardiac Arrest (BASIC-OHCA) registry study, participating sites were selected from both urban rural areas all seven geographical regions across China. All patients with...
Abstract The epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization restore tissue integrity and function adverse environment is challenging. In this work, a long‐term anti‐inflammatory antioxidant hydrogel with mechanical stimulation for re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, γ‐Fe 2 O 3 nanoparticles reported. Glycine‐modified supramolecular acid stable...
Cavernous nerve injury (CNI), resulting in erectile dysfunction (ED), poses a significant threat to the quality of life for men. Strategies utilizing conductive hydrogels have demonstrated promising results treatment peripheral nerves with large diameter (>2 mm). However, integrating convenient minimally invasive operation, antiswelling and immunomodulatory treating small-diameter injured cavernous remains great challenge. Here, sprayable adhesive hydrogel (GACM) composed gelatin, adenine,...
Aliverti, A., S. J. Cala, R. Duranti, G. Ferrigno, C. M. Kenyon, A. Pedotti, Scano, P. Sliwinski, Peter T. Macklem, and Yan. Human respiratory muscle actions control during exercise. Appl. Physiol. 83(4): 1256–1269, 1997.—We measured pressures power of diaphragm, rib cage, abdominal muscles quiet breathing (QB) exercise at 0, 30, 50, 70% maximum workload (W˙max) in five men. By three-dimensional tracking 86 chest wall markers, we calculated the volumes lung- diaphragm-apposed cage...
Abstract Endometriosis is a prevalent gynecological disorder characterized by the presence of endometrial‐like tissue outside uterus, causing chronic pelvic pain, painful periods, and infertility. Despite common use hormone therapy surgical lesion excision in its treatment, there remain significant postoperative risks potential side effects, with high recurrence rate. An efficient nonsurgical treatment for this condition therefore urgently needed. In study, an interventional hydrogel...
Kenyon, C. M., S. J. Cala, Yan, A. Aliverti, G. Scano, R. Duranti, Pedotti, and Peter T. Macklem. Rib cage mechanics during quiet breathing exercise in humans. Appl. Physiol. 83(4): 1242–1255, 1997.—During exercise, large pleural, abdominal, transdiaphragmatic pressure swings might produce substantial rib (RC) distortions. We used a three-compartment chest wall model ( 72: 1338–1347, 1992) to measure distortions of lung- diaphragm-apposed RC compartments (RCp RCa) along with pleural...
The limitations of autologous bone grafts necessitate the development advanced biomimetic biomaterials for efficient cranial defect restoration. bones are typical flat with sandwich structures, consisting a diploe in middle region and 2 outer compact tables. In this study, we originally developed types flat-bone-mimetic β-tricalcium phosphate bioceramic scaffolds (Gyr-Comp Gyr-Tub) by high-precision vat-photopolymerization-based 3-dimensional printing. Both had layers an inner layer gyroid...
Establishing registries to collect demographic characteristics, processes of care, and outcomes patients with out-of-hospital cardiac arrest (OHCA) can better understand epidemiological trends, measure care quality, identify opportunities for improvement. This study aimed describe the design, implementation, scientific significance a nationwide registry-the BASIC-OHCA (Baseline Investigation Out-of-Hospital Cardiac Arrest)-in China.BASIC-OHCA was designed as prospective, multicenter,...
Abstract Successful regeneration of the peripheral nerve relies on collaborative efforts neural cells and immune cells. Conductive hydrogels have yielded promising results in supporting axonal growth; however, their inability to regulate response poor biological integration with tissues hinder repair injured nerves. Herein, an adhesive conductive immunomodulatory hydrogel bandage is developed for regeneration. The prepared from bioactive material extracellular matrix (ECM), oxidized...
Abstract Many hydrogen‐bonded cross‐linked hydrogels possess unique properties, but their limited processability hinders potential applications. By incorporating a hydrogen bond dissociator (HBD) into these hydrogels, we developed injectable 3D printing inks termed diffusion‐induced phase separation (DIPS) inks. Upon extrusion water and subsequent diffusion of HBD, ink cure rapidly. The DIPS‐printed scaffold retained most the original hydrogel properties due to regeneration bonds....
We evaluated the effect of global inspiratory muscle fatigue (GF) on respiratory control during exercise at 30, 60, and 90% maximal power output in normal subjects. Fatigue was induced by breathing against a high resistance until exhaustion. Esophageal gastric pressures, anteroposterior displacement rib cage abdomen, pattern, perceived breathlessness were measured. Induction GF had no ventilatory parameters mild moderate exercise. It altered, however, response to heavy increasing frequency...
Background: Rice bacterial leaf blight, caused by the Gram-negative bacterium Xanthomonas oryzae pv. Oryzae (Xoo), significantly impacts rice production. To address this disease, research efforts have focused on discovering and utilizing novel disease-resistant genes examining their functional mechanisms. Methods Results: In study, a variety of strains were utilized. CX28-3, AX-11, JC12-2, X10 isolated from high-altitude japonica rice-growing region Yunnan Plateau. Additionally, PXO61,...
Levels of adenosine, inosine, and hypoxanthine from the interstitial space at nucleus tractus solitarii were measured by microdialysis in eight 20- to 25-day-old anesthetized spontaneously breathing piglets. Microdialyzed samples collected every 30 min for 2 h after insertion probe ensure stability purine levels then during each normoxia, hypoxia (10% O2–90% N2), normoxia. The purines separated high-pressure liquid chromatography with ultraviolet detection quantified 254-nm wavelength. Tidal...
Ovarian tissue cryopreservation and retransplantation has been offered as a fertility preservation approach for over decade. At least 130 live births have reported after frozen–thawed ovarian transplantation worldwide. The first International Fertility Protection Center in China was established 2015. Until now no birth reported. However, we are able to report the Chinese successful of cryopreserved (September 2016) woman with squamous cell cervical carcinoma. Restoration endocrine function...
Objective The aim of this study was to report on the first 10 cases ovarian tissue cryopreservation (OTC) and retransplantation (OTCT) in China.Methods A retrospective descriptive performed Chinese women with different diseases undergoing OTC/OTCT specialized center China. Patients' function fertility were followed up.Results included five cervical cancer one case each endometrial cancer, breast rectal myelodysplastic syndrome, aplastic anemia, respectively. average age at OTC 33.70 years;...
We evaluated the effect of global inspiratory muscle fatigue on ventilation and respiratory control during CO2 rebreathing in normal subjects. Fatigue was induced by breathing against a high resistance until exhaustion. response curves were measured before after fatigue. During rebreathing, caused decreased tidal volume (VT) an increased frequency but did not change minute ventilation, duty cycle, or mean flow. Both esophageal transdiaphragmatic pressure swings significantly reduced fatigue,...
This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature insufficiency in China.A patient with myelodysplastic syndrome received cryopreservation before hematopoietic stem cell transplantation, and six cortex strips were thawed transplanted into her peritoneal pocket 2 years later.Pregnancy occurred spontaneously 27 months grafting, a healthy girl was born at 38 weeks gestation. Until now, child has developed normally without any major...
Intrinsic positive end-expiratory pressure (PEEPi) due to dynamic hyperinflation has been measured as a plateau airway opening during occlusion (PEEPi,stat). PEEPi also dynamically determined fall in esophageal (Pes) before the inspiratory flow starts (PEEPi,dyn). The aims of current study were systematically compare PEEPi,stat and PEEPi,dyn explain underlying mechanisms their difference. was performed healthy subjects with induced by expiration through Starling resistor. Campbell diagram...
We studied the influence of diaphragmatic fatigue on control ventilation and respiratory muscle contribution to pressure swings in six normal seated subjects. CO2 was rebreathed before after induced by breathing against an inspiratory resistance requiring 60% maximal transdiaphragmatic with each breath until exhaustion. After for a given level end-tidal PCO2, we found that tidal volume, frequency, minute ventilation, duty cycle, mean flow did not change; esophageal were same, but gastric...
Supramaximal stimuli, with time intervals of 100 ms (10 Hz) to 10 (100 Hz), were delivered in pairs the phrenic nerves, bilaterally, five seated normal subjects, while transdiaphragmatic pressure swings (Pdi,s) recorded at relaxed end-expiratory lung volume airways closed. In fresh diaphragms, Pdi,s increased between 10-20 Hz and reached a plateau 20-30 Hz. Diaphragmatic fatigue decreased all frequencies. was assumed be sum two successive responses (T1+T2), T1 being constant any frequency...