A5069037704- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Gut microbiota and health
- Theoretical and Computational Physics
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- IoT-based Smart Home Systems
- Turfgrass Adaptation and Management
- Black Holes and Theoretical Physics
- Insect and Pesticide Research
- Polyamine Metabolism and Applications
- Probiotics and Fermented Foods
- COVID-19 Clinical Research Studies
- Glycosylation and Glycoproteins Research
- Clostridium difficile and Clostridium perfringens research
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Genomics and Phylogenetic Studies
- Forensic Anthropology and Bioarchaeology Studies
- Plant and animal studies
- Physics of Superconductivity and Magnetism
- Pesticide and Herbicide Environmental Studies
- Game Theory and Voting Systems
- Embedded Systems and FPGA Design
University of Amsterdam
2022-2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Kunming University of Science and Technology
2013-2024
Massachusetts Institute of Technology
2020-2024
Zhejiang University
2014-2024
Meizhou City People's Hospital
2024
Amsterdam UMC Location University of Amsterdam
2023-2024
Amsterdam University Medical Centers
2023-2024
Xidian University
2024
Wastewater surveillance represents a complementary approach to clinical measure the presence and prevalence of emerging infectious diseases like novel coronavirus SARS-CoV-2. This innovative data source can improve precision epidemiological modeling understand penetrance SARS-CoV-2 in specific vulnerable communities. Here, we tested wastewater collected at major urban treatment facility Massachusetts detected RNA from N gene significant titers (57 303 copies per ml sewage) period 18 25 March...
Wastewater surveillance has emerged as a useful tool in the public health response to COVID-19 pandemic. While wastewater been applied at various scales monitor population-level dynamics, there is need for quantitative metrics interpret data context of trends. 24-hour composite samples were collected from March 2020 through May 2021 Massachusetts treatment plant and SARS-CoV-2 RNA concentrations measured using RT-qPCR. The relationship between copy numbers gene fragments clinical cases...
Wastewater-based epidemiology has emerged as a promising technology for population-level surveillance of COVID-19. In this study, we present results large nationwide SARS-CoV-2 wastewater monitoring system in the United States. We profile 55 locations with at least six months sampling from April 2020 to May 2021. These represent more than 12 million individuals across 19 states. Samples were collected approximately weekly by treatment utilities part regular service and analyzed RNA...
Abstract The human gut harbors native microbial communities, forming a highly complex ecosystem. Synthetic communities (SynComs) of the are an assembly microorganisms isolated from mucosa or fecal samples. In recent decades, ever-expanding culturing capacity and affordable sequencing, together with advanced computational modeling, started ‘‘golden age’’ for harnessing beneficial potential SynComs to fight gastrointestinal disorders, such as infections chronic inflammatory bowel diseases. As...
A multifunctional sialyltransferase has been cloned from Pasteurella multocida strain P-1059 and expressed in E. coli as a truncated C-terminal His6-tagged recombinant protein (tPm0188Ph). Biochemical studies indicate that the obtained is (1) an α2,3-sialyltransferase (main function), (2) α2,6-sialyltransferase, (3) α2,3-sialidase, (4) α2,3-trans-sialidase. The tPm0188Ph powerful tool synthesis of structurally diverse sialoside libraries due to its relaxed substrate specificity, high...
We present an unquenched calculation of the quark propagator in Landau gauge with $2\text{\hskip-0.22em}+\text{\hskip-0.22em}1$ flavors dynamical quarks. use configurations generated improved staggered (``Asqtad'') action by MILC Collaboration. This has been seen to have excellent rotational symmetry and scaling properties quenched propagator. Quenched calculations are performed on a ${20}^{3}\ifmmode\times\else\texttimes\fi{}64$ lattice nominal spacing $a=0.125\text{ }\text{ }\mathrm{fm}$....
The Landau-gauge gluon propagator is studied using the coarse and fine dynamical MILC configurations. effects of quarks are clearly visible lead to a reduction nonperturbative infrared enhancement relative quenched case. Lattice spacing found be small. spectral function shown violate positivity in both full QCD.
Abstract Current estimates of COVID-19 prevalence are largely based on symptomatic, clinically diagnosed cases. The existence a large number undiagnosed infections hampers population-wide investigation viral circulation. Here, we use longitudinal wastewater analysis to track SARS-CoV-2 dynamics in at major urban treatment facility Massachusetts, between early January and May 2020. was first detected March 3. Viral titers increased exponentially from mid-March mid-April, after which they...
Abstract Glycerol/diol dehydratases catalyze the conversion of glycerol to 3-hydroxypropionaldehyde (3-HPA), basis a multi-component system called reuterin. Reuterin has antimicrobial properties and undergoes chemical conjugation with dietary heterocyclic amines (HCAs). In aqueous solution reuterin is in dynamic equilibrium toxicant acrolein. It was aim this study investigate extent acrolein formation at various physiological conditions determine its role biological activities. The...
The gut microbiome plays an important role in human health and disease. Gnotobiotic animal vitro cell-based models provide some informative insights into mechanistic crosstalk. However, there is no existing system for a long-term co-culture of colonic mucosal barrier with super oxygen-sensitive commensal microbes, hindering the study human-microbe interactions controlled manner.Here, we investigated effects abundant anaerobe, Faecalibacterium prausnitzii, on primary using Gut-MIcrobiome...
Solvents with appropriate acidity are required to simultaneously realize efficient and reversible absorption of NH3. To achieve this goal, a series 1-ethyl-3-methylimidazolium ([emim]Cl)-based DESs different weak acids as the hydrogen-bond donors (HBDs) were prepared characterized. The acidities these cover wide range, pKa values in DMSO ranging from 8.2 18.6. NH3 desorption performance investigated systematically correlated HBDs. behavior was analyzed by spectroscopic characterizations...
The acquisition of the infant gut microbiota is key to establishing a host-microbiota symbiosis. Microbially produced metabolites tightly interact with immune system, and fermentation-derived short-chain fatty acid butyrate considered an important mediator linked chronic diseases later in life. intestinal butyrate-forming bacterial population taxonomically functionally diverse includes endospore formers high transmission potential. Succession, contribution butyrate-producing taxa during...
Abstract Crosstalk of microbes with human gut epithelia and immune cells is crucial for health. However, there no existing system a long-term co-culture innate epithelium oxygen-intolerant commensal microbes, hindering the understanding microbe-immune interactions in controlled manner. Here, we established epithelium-microbe-immune (GuMI) microphysiological to maintain continuous Faecalibacterium prausnitzii/Faecalibacterium duncaniae colonic epithelium, antigen-presenting (APCs, herein...
Fermented dairy constitutes a major dietary source and contains lactose as the main carbohydrate living starter cultures, which can encounter intestinal microbiota after ingestion. To investigate whether dairy-related nutritional microbial modulation impacted composition activity, we employed static fecal fermentations model system consisting of Streptococcus thermophilus wild type β-galactosidase deletion mutant. In addition, conducted single-culture validation studies. 16S rRNA gene-based...
Effective antiretroviral therapy (ART) requires excellent adherence. Little is known about how to improve ART adherence in many HIV/AIDS-affected countries, including China. We therefore assessed an intervention among HIV-positive patients southwestern Eighty subjects were enrolled and monitored for 6 months. Sixty-eight remaining randomized intervention/control arms. In months 7-12, counseled using EDM feedback; controls continued with standard of care. Among subjects, mean CD4 count 86.8...
The form factors in the radiative decay of $J/\psi$ to a scalar glueball are studied within quenched lattice QCD on anisotropic lattices. continuum extrapolation is carried out by using two different spacings. With results these factors, partial width radiatively decaying into pure gauge predicted be 0.35(8) keV, which corresponds branching ratio 3.8(9)x10^{-3}. By comparing with experiments, indicate that f_0(1710) has larger overlap than other related mesons.
Neonicotinoid insecticide (NEO) concentrations in ambient fine particulate matter (PM2.5) and daily exposure via inhalation were investigated during spring fall an urban area Beijing rural areas of Zhengzhou, Henan Province, China. Four NEOs, including imidacloprid, acetamiprid, thiamethoxam clothianidin, assessed using a QuEChERS (quick, easy, cheap, effective, rugged, safe) extraction procedure coupled to liquid chromatography-tandem mass spectrometry. Of 64 PM2.5 samples, 100% contained...
Agricultural use of treated wastewater, biosolids, and animal wastes introduces a multitude contaminants emerging concerns (CECs) into the soil-plant system. The potential for food crops to accumulate CECs depends largely on their metabolism in plants, which at present is poorly understood. Here, we evaluated naproxen ibuprofen, two most-used human drugs from Profen family, Arabidopsis thaliana cells plant. complementary high-resolution mass spectrometry 14C labeling allowed characterization...
Consuming red and processed meat has been associated with an increased risk of colorectal cancer (CRC), which is partly attributed to exposure carcinogens such as heterocyclic amines (HCA) formed during cooking preservation processes. The interaction gut microbes HCA can result in altered bioactivities it shown previously that human microbiota transform mutagenic a glycerol conjugate reduced potential. However, the major form colon are glucuronides (HCA-G) not known whether these...