A5088285841- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Pharmacogenetics and Drug Metabolism
- Ovarian cancer diagnosis and treatment
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Protein Kinase Regulation and GTPase Signaling
- Crystallization and Solubility Studies
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Drug Solubulity and Delivery Systems
Sun Yat-sen University
2025
Capital Medical University
2013-2025
Beijing Obstetrics and Gynecology Hospital
2012-2025
Air Force Medical University
2015-2025
Xijing Hospital
2016-2025
Hangzhou Normal University
2024-2025
Institute of Psychology, Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
Deakin University
2015-2024
Xi'an Jiaotong University
2013-2024
Epithelial cell adhesion molecule (EpCAM) is overexpressed in most solid cancers and an ideal antigen for clinical applications cancer diagnosis, prognosis, imaging, therapy. Currently, of the EpCAM-based diagnostic, prognostic, therapeutic strategies rely on anti-EpCAM antibody. However, use EpCAM antibody restricted due to its large size instability. In this study, we have successfully identified DNA aptamers that selectively bind human recombinant protein. The can specifically recognize a...
Airway tolerance is the usual outcome of inhalation harmless antigens. Although T cell deletion and anergy are likely components tolerogenic mechanisms in lung, increasing evidence indicates that antigen-specific regulatory cells (inducible Treg [iTreg cells]) express Foxp3 also critical. Several lung antigen-presenting have been suggested to contribute tolerance, including alveolar macrophages (MØs), classical dendritic (DCs), plasmacytoid DCs, but whether these possess attributes required...
ABSTRACT Recently, attempts have been made to apply graphene oxide (GO) in the field of biology and medicine, such as DNA sensing drug delivery with some necessary modifications. Therefore, toxicity GO must be evaluated before it is applied further biomedicine. In this paper, cytotoxicity genotoxicity human lung fibroblast (HLF) cells assessed methyl thiazolyl tetrazolium (MTT), sub‐G1 measurement comet assays, mechanism its has explored. Various modifications help us determine factors which...
Abstract Mitogen-activated protein kinase (MAPK) signaling cascade plays a pivotal role in the activation of inflammatory cells. Recent findings revealed that activity p42/44 MAPK (also known as extracellular signal-regulated (ERK)) lungs was significantly higher asthmatic mice than normal controls. We hypothesized inhibition ERK may have anti-inflammatory effects allergic asthma. BALB/c were sensitized with OVA and, upon aerosol challenge, developed airway eosinophilia, mucus...
The lack of a specific targeting strategy against cancer stem cells in current treatment regimens is at least partly responsible for life-threatening cytotoxicity patients undergoing traditional chemotherapy. An effective cell system urgently required the next generation medicine. Epithelial adhesion molecule (EpCAM) overexpressed most solid cancers and it has recently been identified as marker. In this study, we isolated 40-base RNA aptamer that binds to EpCAM from random oligonucleotide...
Abstract: Silver nanoparticles (AgNPs) have attracted much attention as antimicrobial agents and demonstrated efficient inhibitory activity against various viruses, including human immunodeficiency virus, hepatitis B Tacaribe virus. In this study, we investigated if AgNPs could antiviral preventive effects in A/Human/Hubei/3/2005 (H3N2) influenza virus infection. Madin-Darby canine kidney cells infected with AgNP-treated H3N2 showed better viability ( P <0.05 versus control) no obvious...
Insufficient penetration of therapeutic agents into tumor tissues results in inadequate drug distribution and lower intracellular concentration drugs, leading to the increase resistance resultant failure cancer treatment.Targeted delivery solid tumors followed by complete durable retention will significantly improve clinical outcomes therapy.Monoclonal antibodies have been commonly used clinic for treatment, but their limitation penetrating still remains because large size.Aptamers, as...
INTRODUCTION Prostate cancer (CaP) is the second leading malignancy in older men Western countries. The role of CD44 variant 6 (CD44v6) CaP progression and therapeutic resistance still uncertain. Here, we investigated roles CD44v6 metastasis chemo/radioresistance. Expression metastatic cell lines, human primary tissues lymph node metastases was assessed using immunofluorescence immunohistochemistry, respectively. METHODS Knock down (KD) performed PC‐3M, DU145, LNCaP cells small interfering...
Human telomerase reverse transcriptase (hTERT) underlies cancer cell immortalization, and the expression of hTERT is regulated strictly at gene transcription. Here, we report that transcription factor Ets2 required for breast proliferation. Silencing induces a decrease increase in human death. Reconstitution with recombinant rescues apoptosis induced by depression. In vitro vivo analyses show binds to EtsA EtsB DNA motifs on promoter. Mutation either binding site reduces promoter...