A5057802769- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neuropeptides and Animal Physiology
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Oral and Maxillofacial Pathology
- Pain Management and Opioid Use
- Pharmacological Receptor Mechanisms and Effects
- Monoclonal and Polyclonal Antibodies Research
- Extracellular vesicles in disease
- Pediatric Pain Management Techniques
- HER2/EGFR in Cancer Research
- Diet and metabolism studies
- Tumors and Oncological Cases
- Gastric Cancer Management and Outcomes
- RNA regulation and disease
- Hydrogen's biological and therapeutic effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Biomarkers in Disease Mechanisms
- Neuroscience and Neuropharmacology Research
- Nutrition and Health in Aging
- Neonatal and fetal brain pathology
- Enhanced Recovery After Surgery
The University of Texas MD Anderson Cancer Center
2019-2023
Mersin Üniversitesi
2013-2022
Anesthesiology and Surgical Oncology Research Group
2019-2022
Massachusetts Eye Research and Surgery Institute
2021
Plasma (Russia)
2016
Deregulation of noncoding RNAs, including microRNAs (miRs), is implicated in the pathogenesis many human cancers, breast cancer. Through extensive analysis The Cancer Genome Atlas, we found that expression miR-22-3p markedly lower triple-negative cancer (TNBC) than normal tissue. restoration led to significant inhibition TNBC cell proliferation, colony formation, migration, and invasion. We demonstrated reduces eukaryotic elongation factor 2 kinase (eEF2K) by directly binding 3' untranslated...
microRNAs (miRNAs) are single-stranded, noncoding RNA molecules. Given the vast regulatory potential of miRNAs and their often tissue-specific disease-specific expression patterns, being assessed as possible biomarkers to aid diagnosis prediction different types stages cancers, including skin cancer. Basal cell carcinoma (BCC) squamous (SCC) most common forms nonmelanoma cancer (NMSC). BCC originates from basal layer epidermis, while SCC arises epidermal keratinocytes or dermal appendages....
Salivary gland tumors (SGTs) are rare head and neck malignancies consisting of a spectrum with different biological behaviors.In this study we aimed to find out differential expression microRNA profiles between benign malignant SGTs.We investigated the possible role 95 microRNAs in 20 patients salivary comparison 17 without malignancy or diseases. Sixteen were (seven pleomorphic adenomas, nine Warthin tumors), four them (two squamous cell carcinomas, one high grade mucoepidermoid carcinoma,...
MicroRNA (miRNA) is an abundant class of small non-coding RNAs that act as gene regulators. Recent studies have suggested miRNA deregulation associated with the initiation and progression human cancer. However, information about ovarian cancer-related mostly limited to tissue miRNA. The aim this study was find specific profiles plasma-derived miRNAs In present study, expression 740 in plasma from 18 patients 24 healthy women subjects were evaluated using microfluidic based multiplex qRT-PCR....
Recently, the concept of persistent postsurgical opioid use has been described for patients undergoing cancer surgery. Our hypothesis was based on premise that with oral tongue require high dosages opioids before, during, and after surgery, thus a large percentage might develop use.
Background. Age-related cataract (ARC) is the leading cause of visual disability and reversible blindness all over world. The different expressions GST isozymes among animals may explain variations in formation caused by oxidative stress.Objectives. In this study, we evaluated distribution gene polymorphisms ARC patients possible associations between presence polymorphisms.Material Methods. epidemiological data was collected a standard questionnaire blood samples were obtained from 130 159...
The use of opioids in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) is associated shorter survival and not dependent on the expression mu-opioid receptor (MOR). role opioid MOR stage I-III PDAC has been investigated.We conducted retrospective study PDAC. OPRM1 gene tumour tissue non-tumour was measured. Primary endpoints were overall (OS) disease-free (DFS). Secondary included perineural invasion, intraoperative sufentanil consumption, length stay. We performed a subgroup...
Abstract Background Gestational diabetes mellitus (GDM), which has been identified for the first time during pregnancy and is defined as glucose intolerance of varying degrees, one prediabetes states that are at risk developing type 2 diabetes. MicroRNAs (miRNAs) associated with complications even necessary regulation pancreatic development glucose-induced insulin secretion. This study aims to investigate miRNAs expressed in maternal plasma detect availability a biomarker diagnosis GDM....
The aim of this study was to investigate the expression levels miR-126-3p, miR-182-5p, miR-183-5p, miR-184, miR-221-3p, and miR-205-5p in primary pterygium tissue compare these with those healthy conjunctiva tissue.Twenty-four patients who were diagnosed grade 3 scheduled for surgery between January 2014 2016 had no systemic disease or other ocular pathology included study. control group comprised nasal interpalpebral conjunctival specimens from 24 age- sex-matched history than cataract....
Objective: Apoptosis and its regulatory mechanisms take part in renal ischemia–reperfusion (I/R) injury which can result acute failure the inhibition of caspase is considered as a new therapeutic strategy. In this context, we investigated antiapoptotic cytoprotective effects iloprost, prostacyclin analog, kidney distant organ. Methods: Wistar albino rats were randomized into five groups (n = 12 each) sham, ischemia, I/R, iloprost (10 μg kg−1), I/R + kg−1). A 4 h reperfusion procedure was...
Cancer is the second most common cause of death in United States. The vast majority cancer-related deaths occur due to metastatic disease, which may be result direct extension, lymphatic spread, or hematogenous spread cancer.1,2 As such, our ability effectively treat cancer mostly dependent on capacity stop process metastasis. Even though surgery mainstay for treatment many patients, it has been theorized that accelerate tumor progression and micrometastasis development.3,4 Given comments...