A5101640102- Nanoplatforms for cancer theranostics
- Luminescence Properties of Advanced Materials
- Luminescence and Fluorescent Materials
- Insect Resistance and Genetics
- MicroRNA in disease regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Silk-based biomaterials and applications
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Nanoparticles: synthesis and applications
- Invertebrate Immune Response Mechanisms
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Neurobiology and Insect Physiology Research
- Silkworms and Sericulture Research
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Microplastics and Plastic Pollution
- Effects and risks of endocrine disrupting chemicals
- Entomopathogenic Microorganisms in Pest Control
- Mosquito-borne diseases and control
- Cardiac, Anesthesia and Surgical Outcomes
- Legume Nitrogen Fixing Symbiosis
- Epigenetics and DNA Methylation
Xi'an Jiaotong University
2020-2025
Tan Kah Kee Innovation Laboratory
2022-2025
Chinese Academy of Agricultural Sciences
2019-2025
Jiangsu University of Science and Technology
2018-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Sericultural Research Institute
2018-2025
Beihang University
2025
Chinese Academy of Sciences
2013-2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes white adipose tissue (WAT) produces “white adipocytes” with characteristics brown fat and leads to a reduction adiposity its metabolic complications. Although BMP4 is known induce commitment pluripotent stem cells the adipocyte lineage by producing that possess preadipocytes, effects on mature phenotype function were unknown. Forced expression transgene mice gives rise reduced WAT mass size along an increased number cell types...
Atherosclerosis (AS) is a crucial contributor to various cardiovascular diseases (CVDs), which seriously threaten human life and health. Early accurate recognition of AS plaques essential for the prevention treatment CVD. Herein, we introduce an AS-targeting nanoprobe based on near-infrared (NIR) persistent luminescence nanoparticles (PLNPs), developing highly sensitive NIR (PersL) plaque imaging technique successfully realizing early detection. The exhibits good monodispersity regular...
Bisphenol A (BPA) is widely used in plastic products, through which humans are exposed to it. Accumulating evidence suggests that BPA exposure associated with β-cell dysfunction. Mitochondrial defects can cause impairment and failure of β cells, but there little information about the effects on mitochondrial function cells. In this study, we assessed role mitochondria-mediated mechanisms underlying BPA-induced dysfunction resulting apoptosis. INS-1 cells were cultured 0, 0.0020, 0.020, 0.20,...
Centromere protein‐A (CENP‐A), a histone‐H3 variant, plays an essential role in cell division by ensuring proper formation and function of centromeres kinetochores. Elevated CENP‐A expression has been associated with cancer development. This study aimed to establish whether elevated can be used as prognostic predictive biomarker. Molecular profiling human cancers was investigated using genomic, transcriptomic patient information from databases, including COSMIC, Oncomine, Kaplan–Meier...
Loss of WW domain-containing oxidoreductase (Wwox) expression has been observed in breast cancer (BC). However, its regulatory effects are largely unknown, especially triple-negative (TNBC). Herein, gene profiling revealed that JAK/STAT3 pathway was one the most differentially modulated pathways basal-like BC cells. The lower Wwox significantly correlated with high activation STAT3 cells and TNBC tissues. Overexpression markedly inhibited proliferation metastasis by suppressing activation,...
Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals, which present ubiquitously in daily life. Accumulating evidence indicates that exposure to BPA contributes metabolic syndrome. In this study, we examined whether perinatal predisposed offspring fatty liver disease: hepatic manifestation Wistar rats were exposed 50 μg/kg per day or corn oil throughout gestation and lactation by oral gavage. Offspring fed a standard chow diet (SD) high-fat (HFD) after weaning....
Background: Docetaxel (DOC) is widely used as a chemotherapy drug for various tumors, including gastric cancer (GC), but the clinical application of DOC has been limited due to hydrophobicity drug. We aimed formulate multifunctional nanoparticle (NP) system reduce side effects agent, promote synergistic therapeutic effects, and achieve targeted delivery therapy. Methods: The polyethylene glycol-poly(ε-caprolactone) NPs (PEG-PCL NPs) were prepared by ring opening copolymerization technique...
Abstract Here, a novel super‐long, ultraviolet A region (UVA), persistent luminescent (PerL) material, LiYGeO 4 :Bi 3+ , is developed. After irradiation at 254 nm for 10 min, the UVA PerL of can persist more than 300 h. In addition, also possesses strong emission with power density 11.83 mW m −2 s after removal excitation source. Even 72 h, spectrum still be clearly detected, which same as photoluminescence and originated from Bi emitting centers. Furthermore, exhibits photostimulated...
Nanosized dual window afterglow particles possess X-ray rechargeable and photo-stimulation properties for long-term bioimaging.
Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study was aimed to investigate the participation of Tregs development postoperative cognitive dysfunction (POCD).Surgery-associated disorder induced 18-month-old mice subjected internal fixation tibial fracture. Morris water maze used examine function. Splenic were collected for RNA...
Abstract Background Adipocyte hyperplasia is associated with obesity and arises due to adipogenic differentiation of resident multipotent stem cells in the vascular stroma adipose tissue remote other organs. The mechanistic characterization adipocyte has been researched murine pre-adipocyte models (i.e. 3T3-L1 3T3-F442A), revealing that growth-arrest pre-adipocytes undergo mitotic clonal expansion regulation process relies on sequential expression three key transcription factors (C/EBPβ,...