A5065620658- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Macrophage Migration Inhibitory Factor
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Cell Adhesion Molecules Research
- Head and Neck Cancer Studies
- T-cell and B-cell Immunology
- Chronic Kidney Disease and Diabetes
Shanghai Jiao Tong University
2017-2025
Tianjin Medical University General Hospital
2021-2025
Fudan University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Zhongshan Hospital
2015-2024
Sun Yat-sen University
2015-2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sichuan University
2017-2023
Inflammatory mediators that originate in vascular and extravascular tissues promote coronary lesion formation. Adipose tissue may function as an endocrine organ contributes to inflammatory burden patients at risk of cardiovascular complications. In this study, we sought compare expression epicardial subcutaneous adipose stores with critical CAD.Paired samples were harvested the outset elective CABG surgery (n=42; age 65+/-10 years). Local chemokine (monocyte chemotactic protein [MCP]-1)...
Background The adventitia undergoes remodeling changes after a deep medial coronary injury. Because this process is associated with the formation of adventitial myofibroblasts, which resemble smooth muscle (SM) cells, we have examined myofibroblast involvement in development neointima. Methods and Results In porcine model, severe endoluminal injury resulted fibroblast proliferation remodeling. Significant responses were increased neointimal ( P <.01). To examine contribution cells to...
Background Intraluminal thrombus formation and medial smooth muscle (SM) cell proliferation are recognized responses of the arterial system to injury. In contrast these well-characterized processes during vascular repair, changes involving adventitia have been largely neglected in previous studies. Hence, goal this investigation was assess response coronary Methods Results Adventitial porcine arteries subjected injury were characterized by immunohistochemistry, histochemistry, microscopic...
Multiple pathways contribute to accelerated coronary atherosclerosis in diabetics, including increased oxidative stress and inflammatory burden. Accordingly, the mechanisms of abnormal formation reactive oxygen species changes gene expression were examined diabetic arteries.In pigs with streptozotocin-induced diabetes, superoxide was augmented media adventitia because NAD(P)H oxidase activity (3 months) accompanied by upregulated its cytosolic subunit, p22phox. Diabetes-induced resulted...
BACKGROUND Smooth muscle cell proliferation and extracellular matrix accumulation are the principal mechanisms leading to vascular restenosis. We have previously demonstrated growth-inhibitory effect of antisense oligomers targeting c-myc proto-oncogene in human smooth cells. The goal this study was investigate whether reduce neointimal formation balloon-denuded porcine coronary arteries. METHODS AND RESULTS First, type I collagen synthesis, which reflects synthetic function, markedly...
It is still controversial whether elevated plasma homocysteine and the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene are risk factors for stroke. The aim present study was to investigate association between 2 stroke in Chinese a large case-control study.We recruited 1823 patients (807 cerebral thrombosis, 513 lacunar infarction, 503 intracerebral hemorrhage) 1832 controls. Total determined by high-performance liquid chromatography. genotyped polymerase chain reaction...
Diabetes mellitus (DM) and hypercholesterolemia (HC) have emerged as major risk factors for Alzheimer's disease, highlighting the importance of vascular health to normal brain functioning. Our previous study showed that DM HC favor developmen
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory diseases. Methylprednisolone (MP) is a common drug against inflammation in clinic. In this study, we aim to investigate the protective effect of MP on ALI potential mechanisms. Male BABL/c mice were injected through tail vein using lipopolysaccharide (LPS, 5 mg/kg) with or without mg/kg MP. Lung mechanics, tissue examined. Macrophage subsets identified by flow cytometry. Macrophages cultured from...
Lectin-like oxLDL receptor-1 (LOX-1) mediates the uptake of oxidized low-density lipoprotein (oxLDL) in endothelial cells and macrophages. However, different atherogenic potential LOX-1-mediated macrophage remains unclear. The present study was designed to investigate vivo role LOX-1 atherogenesis.Endothelial-specific transgenic mice were generated using Tie2 promoter (LOX-1TG). Oxidized enhanced cultured cells, but not macrophages LOX-1TG mice. Six-week-old male wild-type (WT) fed a...
Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study was aimed to investigate the participation of Tregs development postoperative cognitive dysfunction (POCD).Surgery-associated disorder induced 18-month-old mice subjected internal fixation tibial fracture. Morris water maze used examine function. Splenic were collected for RNA...
Immune checkpoint inhibitors have limited efficacy in hepatocellular carcinoma (HCC). Macrophages are the most abundant immune cells HCC, suggesting that a better understanding of intrinsic processes by which tumor regulate macrophages could help identify strategies to improve response immunotherapy. As signaling lymphocytic activation molecule (SLAM) family members various functions, we investigated role specific SLAM receptors immunobiology HCC. Comparison transcriptomic landscapes...
Abstract Hepatocellular carcinoma (HCC) stands as the fifth most prevalent malignant tumor on a global scale and presents second leading cause of cancer-related mortality. DNA damage-based radiotherapy (RT) plays pivotal role in treatment HCC. Nevertheless, radioresistance remains primary factor contributing to failure radiation therapy HCC patients. In this study, we investigated functional transketolase (TKT) repair double-strand breaks (DSBs) Our research unveiled that TKT is involved DSB...
This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogenous Chinese sample with total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage diabetes/IGH in the Chinese. The region showing from entire group analysis located chromosome 6q21-q23 (128.93 cM, 1-LOD [logarithm odds] support interval between 124 142 according Marshfield genetic map), maximum likelihood score 6.23,...
Abstract —Reactive oxygen species (ROS), produced by cellular constituents of the arterial wall, provide a signaling mechanism involved in vascular remodeling. Because adventitial fibroblasts are actively coronary remodeling, we examined whether changes redox state affect their phenotypic characteristics. To this end, superoxide anion production and NAD(P)H oxidase activity were measured porcine arteries vivo, effect ROS generation on fibroblast proliferation was vitro. Superoxide (SOD-...
Transforming growth factor-β1 (TGF-β1) plays a central role in tissue repair owing to its modulating effects on cell and the synthesis of extracellular matrix. We have previously shown that adventitial fibroblasts differentiate myofibroblasts after endoluminal injury, thereby contributing arterial remodeling. Since TGF-β1 exerts several biologic actions attributed myofibroblasts, we examined myofibroblast formation porcine model balloon overstretch coronary artery injury. transcripts were...
Deletion of the mitochondrial gene p66(Shc) protects from endothelial dysfunction and atherosclerotic plaque formation in mice fed a high-fat diet. However, molecular mechanisms underlying this beneficial effect have not yet been delineated. The present study was designed to elucidate proatherogenic by which mediates oxidized low-density lipoprotein (oxLDL) uptake endothelium, critical step formation.Incubation human aortic cells with oxLDL led phosphorylation at Ser36. Inhibition...
The throat is an ecological assemblage involved human cells and microbiota, the colonizing bacteria are important factors in balancing this environment. However, bacterial community profile has thus been poorly investigated. purpose of study was to investigate microbial biology larynx analyze biodiversity laryngeal carcinoma patients compared a control population case-control study. Barcoded pyrosequencing analysis 16S rRNA gene used. We collected tissue samples from 29 with 31 vocal cord...
Stroke is a leading cause of morbidity and mortality, its incidence increases with age. Both in animals humans, oxidative stress appears to play an important role ischaemic stroke, or without reperfusion. The adaptor protein p66Shc key regulator reactive oxygen species (ROS) production mediator ischaemia/reperfusion damage ex vivo hearts. Hence, we hypothesized that may be involved brain damage. To this end, investigated whether genetic deletion protects from injury. Transient middle...