A5088939674- Bone and Dental Protein Studies
- Pancreatic and Hepatic Oncology Research
- Nigella sativa pharmacological applications
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- dental development and anomalies
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Digestive system and related health
- Renin-Angiotensin System Studies
- Natural Compounds in Disease Treatment
- Urological Disorders and Treatments
- Microtubule and mitosis dynamics
- Pharmacological Effects of Natural Compounds
- Gastrointestinal Tumor Research and Treatment
- Bioactive Compounds and Antitumor Agents
- Peroxisome Proliferator-Activated Receptors
- Chemokine receptors and signaling
- AI in cancer detection
- Liver physiology and pathology
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Oral and Maxillofacial Pathology
Thomas Jefferson University
2005-2023
University of New England
2015-2022
New England College
2015
Philadelphia University
2011-2013
Thomas Jefferson University Hospital
2013
University of Nebraska Medical Center
2010
GlaxoSmithKline (United States)
2003
Bryn Mawr Hospital
2003
University of Pennsylvania
2001-2002
Inflammatory mediators that originate in vascular and extravascular tissues promote coronary lesion formation. Adipose tissue may function as an endocrine organ contributes to inflammatory burden patients at risk of cardiovascular complications. In this study, we sought compare expression epicardial subcutaneous adipose stores with critical CAD.Paired samples were harvested the outset elective CABG surgery (n=42; age 65+/-10 years). Local chemokine (monocyte chemotactic protein [MCP]-1)...
Pancreatic cancer is one of the most lethal cancers in world, as it continues to be resistant any therapeutic approaches. The high molecular weight glycoprotein mucin 4 (MUC4) aberrantly expressed pancreatic and contributes regulation differentiation, proliferation, metastasis, chemoresistance cells. absence its expression normal ductal cells makes MUC4 a promising target for novel therapeutics. Natural products have been widely investigated potential candidates therapies, thymoquinone (TQ),...
Pancreatic ductal adenocarcinoma (PDAC) is virtually therapy-resistant. As noninvasive lesions progress to malignancy, the precursor period provides a window for cancer therapies that can interfere with neoplastic progression. Thymoquinone (Tq), major bioactive component of essential oil from Nigella sativa ’s seeds, has demonstrated antineoplastic activities in multiple cancers. In this study, we investigated potential Tq human PDAC cell lines, AsPC-1 and MiaPaCa-2. (10–50 μ M) inhibited...
Pancreatic cancer (PC) is one of the most aggressive and challenging types to effectively treat, ranking as fourth-leading cause death in United States. We investigated if exposures angiotensin II receptor blockers (ARBs) or I converting enzyme (ACE) inhibitors after PC diagnosis are associated with survival.PC patients were identified by ICD-9 procedure codes among 3.7 million adults living Emilia-Romagna Region from their administrative health care database containing patient data on...
Objectives: Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy with annual mortality rate close to its incidence. We recently demonstrated that angiotensin II (AngII) type 1 receptor (AT1R) might be involved in PDA angiogenesis. This study evaluated the antiproliferative and proapoptotic effects of AT1R blocker, losartan, cells different p53 mutation status. Methods: Cell cycle was analyzed by flow cytometric analysis DNA content; apoptosis annexin V-fluorescein...
Pancreatic cancer is one of the deadliest cancers due to early rapid metastasis and chemoresistance. Recently, epithelial mesenchymal transition (EMT) was shown play a key role in pathogenesis pancreatic cancer. To understand caveolin-1 (Cav-1) EMT, we over-expressed Cav-1 cell line, Panc 10.05, that does not normally express Cav-1. Here, show expression cells induces an phenotype promotes cell-cell contact, with increased plasma membrane bound E-cadherin beta-catenin. Mechanistically, Snail...
The goal of this study was to provide insight into the mechanism by which bariatric surgical procedures led weight loss and improvement or resolution diabetes. Global biochemical profiling used evaluate changes occurring in nondiabetic type 2 diabetic (T2D) patients experiencing either less extreme sleeve gastrectomy a full gastric bypass. We were able identify metabolism that affected standard preoperation liquid diet as well surgery itself. Preoperation weight-loss associated with strong...
Background: Lymph node (LN) assessment is a critical component in the staging and management of cutaneous melanoma. Traditional histopathological evaluation, supported by immunohistochemical staining, gold standard for detecting LN metastases. However, process labor-intensive, requiring analysis multiple tissue levels, which increases both time cost. With growing integration artificial intelligence (AI) into clinical workflows, there potential to streamline this process, enhancing efficiency...
Osteopontin (OPN), a phosphorylated glycoprotein that binds to an integrin-binding motif, has been shown regulate nitric oxide (NO) production via inhibition of induced NO synthase (iNOS) synthesis. In the transplanted islets, iNOS and toxic amounts are produced as result islets infiltration with inflammatory cells proinflammatory cytokines. Here, we demonstrate addition OPN before IL-1beta in freshly isolated rat improved their glucose stimulated insulin secretion dose-dependently inhibited...
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with etiological association cigarette smoking. Nicotine, an important component of cigarettes, exists at high concentrations in the bloodstream smokers. Osteopontin (OPN) secreted phosphoprotein that confers on cancer cells migratory phenotype and activates signaling pathways induce cell survival, proliferation, invasion, metastasis. Here, we investigated potential molecular basis nicotine's role PDA through studying its effect OPN....
According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis performed who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 2012. diagnosis correlated clinicopathologic...
Osteopontin (OPN) is a secreted acidic phosphoprotein that binds to cell-surface integrin-binding motif and involved in many inflammatory immune-modulating disorders. There compelling evidence soluble OPN can variety of situations help cells survive an otherwise lethal insult. In this study we show localized the rat pancreatic islets ducts. Staining serial sections with islet hormone antibodies showed all express OPN. Rats treated single dose streptozotocin (STZ; 50 mg/kg) acute upregulation...